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Category: Gynecology | Monthly Briefing

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June 2012 Briefing - OBGYN & Women’s Health

Last Updated: July 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in OBGYN & Women's Health for June 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Myrbetriq Approved for Overactive Bladder

FRIDAY, June 29 (HealthDay News) -- Myrbetriq (mirabegron) has been approved to treat adults with overactive bladder, a condition affecting some 33 million Americans, the U.S. Food and Drug Administration said Thursday in a news release.

overactive bladder

Objective Decrease in Hot Flashes After Acute Exercise

FRIDAY, June 29 (HealthDay News) -- For perimenopausal and postmenopausal women, a bout of moderate-intensity physical activity (PA) is associated with objective and subjective improvements in hot flashes (HFs), but performing more moderate PA than usual correlates with more self-reported HFs for women with lower levels of fitness, according to a study published online June 25 in Menopause.

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Lengthy Periods of Standing, Working Impact Fetal Growth

FRIDAY, June 29 (HealthDay News) -- Long periods of standing and long working hours per week during pregnancy may negatively influence intrauterine growth, including fetal weight and head circumference (HC), according to a study published online June 27 in Occupational & Environmental Medicine.

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Heart Problems Seen in Fetal Growth-Restricted Pregnancy

FRIDAY, June 29 (HealthDay News) -- Women with normotensive fetal growth-restricted pregnancies have impaired myocardial relaxation and asymptomatic diastolic dysfunction, according to a study published online June 25 in Hypertension.

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Supreme Court Upholds Health Care Reform Law

THURSDAY, June 28 (HealthDay News) -- The U.S. Supreme Court voted June 28 to uphold the constitutionality of the Patient Protection and Affordable Care Act (PPACA), which has been the subject of debate and multiple lawsuits since its 2010 inception.

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Muscle Mass Linked to Parameters of Bone Health

THURSDAY, June 28 (HealthDay News) -- Muscle mass is associated with bone parameters at several sites in the body, according to a study published online May 23 in the Journal of Bone and Mineral Research.

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Hyperinsulinemia in Early Adulthood Tied to Later HTN

THURSDAY, June 28 (HealthDay News) -- Young adults with hyperinsulinemia are significantly more likely to have hypertension (HTN) later in life, regardless of sex, ethnicity, or body weight, according to a study published in the July issue of Diabetes Care.

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Longer Labor for Women With Fear of Childbirth

THURSDAY, June 28 (HealthDay News) -- Women with a fear of childbirth have a significantly increased duration of labor, even after adjusting for multiple confounding variables, according to a study published online June 27 in BJOG: An International Journal of Obstetrics and Gynaecology.

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ART Live-Birth Rates Can Approach Natural Fecundity

WEDNESDAY, June 27 (HealthDay News) -- During assisted reproductive technology, increasing maternal age and number of cycles is linked to lower live-birth rates with the use of autologous oocytes, but not donor oocytes, according to a study published in the June 28 issue of the New England Journal of Medicine.

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Men and Women Appear to Respond Differently to Statins

WEDNESDAY, June 27 (HealthDay News) -- Statin therapy appears to reduce the risk of recurrent cardiovascular events in both men and women, but it may not reduce the risk of stroke or all-cause mortality in women, according to a meta-analysis published in the June 25 issue of the Archives of Internal Medicine.

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Home-Based Intervention Linked to Lower BMI at Age 2

WEDNESDAY, June 27 (HealthDay News) -- A home-based intervention comprising eight visits from trained nurses to new mothers in the pre- and postnatal period is associated with lower body mass index (BMI) in children at age 2, according to a study published online June 26 in BMJ.

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Long-Term Adverse Cardiac Outcomes for Low-Carb Diets

WEDNESDAY, June 27 (HealthDay News) -- Women who follow low carbohydrate-high protein diets have an increased risk of cardiovascular disease, according to a study published online June 26 in BMJ.

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Bacterial Vaginosis Linked to Increased HIV-1 Transmission

WEDNESDAY, June 27 (HealthDay News) -- Bacterial vaginosis is associated with a three-fold higher risk of HIV-1 transmission from infected women to their uninfected male partners, according to a study published online June 26 in PLoS Medicine.

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Prenatal Exposure to Butylbenzyl Phthalate Linked to Eczema

WEDNESDAY, June 27 (HealthDay News) -- Prenatal exposure to butylbenzyl phthalate (BBzP), as assessed by increased concentrations of monobenzyl phthalate (MBzP) in the urine, is associated with an increased risk of early-onset eczema in offspring, according to a study published online June 26 in Environmental Health Perspectives.

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Nomogram Developed to Estimate Early Breast Cancer Survival

WEDNESDAY, June 27 (HealthDay News) -- A nomogram has been developed to predict five- and 10-year mastectomy-free survival (MFS) in older women with early breast cancer and estimate the predicted benefit of radiation therapy (RT) following conservative surgery (CS), according to research published online June 25 in the Journal of Clinical Oncology.

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Duplicate Payments by Federal Government Increasing

WEDNESDAY, June 27 (HealthDay News) -- The federal government spends a substantial and increasing amount on individuals who are dually enrolled in separate managed care programs (the Veterans Affairs health care system [VA] and Medicare Advantage plan [MA]), according to a study published online June 26 in the Journal of the American Medical Association to coincide with presentation at the Annual Research Meeting of AcademyHealth, held from June 24 to 26 in Orlando, Fla.

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Use of Electronic Records Tied to Fewer Malpractice Claims

TUESDAY, June 26 (HealthDay News) -- Use of electronic health records (EHRs) is associated with fewer medical malpractice claims among physicians from multiple surgical and medical specialties, according to a research letter published online June 25 in the Archives of Internal Medicine.

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Older Mothers More Prone to Psychological Distress

TUESDAY, June 26 (HealthDay News) -- First-time mothers in their early 30s and beyond are more likely to experience psychological distress during pregnancy and after birth than younger women, but only if they have a history of depression, according to a study published online June 18 in BJOG: An International Journal of Obstetrics and Gynaecology.

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Recreational Physical Activity Reduces Breast Cancer Risk

MONDAY, June 25 (HealthDay News) -- During the reproductive and postmenopausal years, recreational physical activity (RPA) at any intensity level is associated with reduced breast cancer risk, according to a study published online June 25 in Cancer.

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Many Female Sexual Assault Survivors Have Severe Pain

FRIDAY, June 22 (HealthDay News) -- More than 50 percent of women who survive sexual assault experience severe pain, although few receive medication, according to a study published online June 15 in The Journal of Pain.

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Polycystic Ovarian Syndrome Ups Risk of Type 2 Diabetes

THURSDAY, June 21 (HealthDay News) -- Middle-aged women with polycystic ovary syndrome (PCOS) are at increased risk of developing type 2 diabetes, according to a prospective long-term study published online June 14 in Diabetes.

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Eating Disorder Symptoms Evident in Women Over 50

THURSDAY, June 21 (HealthDay News) -- For women aged 50 years and older there is wide endorsement of weight and shape concerns and of eating disorder symptoms, dieting, and body checking behaviors, according to a study published online June 21 in the International Journal of Eating Disorders.

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Half of Residents Report Working While Sick

THURSDAY, June 21 (HealthDay News) -- About half of residents have worked while sick, with many reporting feeling obligated to colleagues and patients, according to a research letter published online June 18 in the Archives of Internal Medicine.

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Prophylactic Midurethral Sling Reduces Urinary Incontinence

WEDNESDAY, June 20 (HealthDay News) -- For women without preoperative stress incontinence, placement of a midurethral sling at the time of vaginal prolapse surgery correlates with reduced rates of urinary incontinence at three and 12 months as well as increased rates of adverse events, according to a study published in the June 21 issue of the New England Journal of Medicine.

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Diabetes Linked to Increased Cause-Specific Mortality

WEDNESDAY, June 20 (HealthDay News) -- Diabetes is linked with a significantly increased risk of death from many diseases, including specific cancers, in both men and women, according to a study published online June 14 in Diabetes Care.

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Multi-Drug Regimens Cut HIV Transmission Versus Zidovudine

WEDNESDAY, June 20 (HealthDay News) -- For infants of mothers with HIV who did not receive antenatal antiretroviral therapy (ART), treatment with two or three drugs reduces transmission compared with zidovudine alone; and more infants treated with nevirapine together with zidovudine and lamivudine have virologic failure by six months, according to two studies published in the June 21 issue of the New England Journal of Medicine.

Abstract - Nielsen-Saines
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Teen Pregnancies Down; Rates Up for Older Women in 2008

WEDNESDAY, June 20 (HealthDay News) -- Rates of teen pregnancies reached a historic low in 2008, while pregnancy rates for women in their 30s and early 40s increased, according to a June 20 report issued by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Periodontitis Linked to HPV-Positive Head, Neck Tumors

WEDNESDAY, June 20 (HealthDay News) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published online June 18 in the Archives of Otolaryngology -- Head & Neck Surgery.

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Surgical Interns Concerned About Duty-Hour Restrictions

TUESDAY, June 19 (HealthDay News) -- Surgical interns have significant concerns about the impact of new Accreditation Council for Graduate Medical Education (ACGME) core competency duty-hour restrictions on the quality of their training, according to a study published in the June issue of the Archives of Surgery.

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Hemoglobin A1C Inadequate for Postpartum Diabetes Screening

TUESDAY, June 19 (HealthDay News) -- For postpartum women who have had gestational diabetes mellitus (GDM), the hemoglobin A1c (A1C) test criteria alone or in combination with fasting glucose test criteria does not provide sensitive and specific diagnosis of abnormal carbohydrate metabolism compared with the gold-standard oral glucose tolerance test (OGTT), according to a study published online June 11 in Diabetes Care.

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Germ-Line BRCA1/2 Testing Recommended in Ovarian Cancer

TUESDAY, June 19 (HealthDay News) -- Due to the potential survival and treatment response implications of BRCA mutation status, it is recommended that germ-line BRCA1/2 testing be offered to all women diagnosed with nonmucinous ovarian carcinoma, regardless of family history, according to research published online June 18 in the Journal of Clinical Oncology.

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Research Suggests Flavocoxid Causes Acute Liver Injury

TUESDAY, June 19 (HealthDay News) -- Flavocoxid, a proprietary prescription medical food used to treat osteoarthritis, appears to cause acute liver injury within months of initiating use, according to research published in the June 19 issue of the Annals of Internal Medicine.

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Mental Imagery Doesn't Improve Surgeon Performance

MONDAY, June 18 (HealthDay News) -- Mental imagery (MI) training does not result in an improvement in objective surgical assessment of novice gynecological surgeons performing vaginal hysterectomies (VHs), but does correlate with improvements in resident self-confidence, according to a study published online June 7 in BJOG: An International Journal of Obstetrics and Gynaecology.

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Multiple Tumor Zones Should Be Sampled in Breast Cancer

MONDAY, June 18 (HealthDay News) -- For any given patient with breast cancer, the expression of microRNAs (miRNAs), which has been linked to tumor development and progression, varies greatly within the same tumor and lymph node metastases, according to a study published online June 18 in The Journal of Molecular Diagnostics.

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Review: Vitamin D Plus Calcium Linked to Mortality Reduction

FRIDAY, June 15 (HealthDay News) -- Analyses of data from individual patients and trials indicate that vitamin D supplementation in combination with calcium is linked to a reduction in mortality for elderly adults, but this effect is not seen for vitamin D alone, according to research published online May 17 in the Journal of Clinical Endocrinology & Metabolism.

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Weight Loss Linked to Reduced Cancer Incidence, Mortality

FRIDAY, June 15 (HealthDay News) -- Weight loss, particularly intentional weight loss, is associated with a reduced incidence of cancer and mortality, especially for women and for obesity-related cancers, according to a review published online June 4 in Obesity Reviews.

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Pre-Op Breast Pain in ~28 Percent of Breast Cancer Patients

THURSDAY, June 14 (HealthDay News) -- More than a quarter of women about to undergo breast cancer surgery experience breast pain, with genetic polymorphisms in inflammatory cytokines correlating with pain, according to a study published in the May issue of The Journal of Pain.

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CDC: Preventive Health Services Underused Before 2010

THURSDAY, June 14 (HealthDay News) -- Prior to 2010, only about half of all U.S. adults received key preventive health services, according to a report published in the June 15 supplement of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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Lifestyle Factors for Low-Motile Sperm Concentration Identified

THURSDAY, June 14 (HealthDay News) -- Common lifestyle factors associated with low-motile sperm concentration (MSC) include a history of testicular cancer, being in manual labor or not working, and black ethnicity, while men who wear loose underwear and have had a previous conception are less likely to have low MSC, according to a study published online June 12 in Human Reproduction.

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Female APOE ε4 Carriers Have Preclinical Signs of Alzheimer's

THURSDAY, June 14 (HealthDay News) -- Healthy elderly women carrying the apolipoprotein E type 4 allele (APOE ε4) show changes in the brain's memory network characteristic of Alzheimer's disease, which can be observed before any symptoms appear, according to a study published in the June 13 issue of The Journal of Neuroscience.

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Pregnancy Deemed Feasible After Liver Transplant

THURSDAY, June 14 (HealthDay News) -- For liver transplant (LT) recipients, pregnancy is feasible, but the rates of obstetric complications, including preeclampsia, cesarean section delivery, and preterm delivery, are higher than in the general population, according to a study published in the June issue of Liver Transplantation.

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Trend Shows Early Menopause Linked to Cerebral Aneurysm

THURSDAY, June 14 (HealthDay News) -- Younger age of menopause is associated with a trend toward an increased likelihood of cerebral aneurysm, according to a study published online June 13 in the Journal of NeuroInterventional Surgery.

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Statins Exhibit Adverse Effect on Energy, Exertional Fatigue

THURSDAY, June 14 (HealthDay News) -- For relatively healthy individuals, particularly women, statin use may be associated with reduced energy and exertional fatigue, according to a research letter published online June 11 in the Archives of Internal Medicine.

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Ethinyl Estradiol Dose, Progestin Type Affect the Pill's Stroke Risk

WEDNESDAY, June 13 (HealthDay News) -- The risk of thrombotic stroke and myocardial infarction is increased for women who take oral contraceptives that include ethinyl estradiol, with the relative risk varying according to the dose of ethinyl estradiol and the progestin type, according to a study published in the June 14 issue of the New England Journal of Medicine.

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In Vitro Fertilization Linked to Multiple Sclerosis Relapse

WEDNESDAY, June 13 (HealthDay News) -- Women with multiple sclerosis (MS) who undergo in vitro fertilization (IVF) are at greater risk of relapse after treatment, particularly if they receive gonadotrophin releasing hormone (GnRH) agonists or if IVF fails, according to a study published online June 11 in the Journal of Neurology, Neurosurgery & Psychiatry.

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Gender Gap Exists in Physician Researchers' Salaries

TUESDAY, June 12 (HealthDay News) -- A survey of mid-career academic physician researchers shows that gender differences in salary exist even after adjusting for differences in specialty, institutional characteristics, academic productivity, academic rank, and work hours, according to a study published in the June 13 issue of the Journal of the American Medical Association.

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Perjeta Approved for Advanced Breast Cancer

TUESDAY, June 12 (HealthDay News) -- Perjeta (pertuzumab) has been approved by the U.S. Food and Drug Administration to treat people with HER2-positive late-stage breast cancer, the agency said in a news release.

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Task Force Questions Use of Vitamin D, Calcium Supplements

TUESDAY, June 12 (HealthDay News) -- Current evidence is insufficient to support the use of vitamin D and calcium supplements to protect against cancer or osteoporotic fractures, according to a draft recommendation issued by the U.S. Preventive Services Task Force (USPSTF).

Draft Recommendation Statement

Breast Cancer Incidence Down With Metformin Use in Diabetes

TUESDAY, June 12 (HealthDay News) -- For postmenopausal women with diabetes, use of metformin is associated with lower incidence of invasive breast cancer, according to a study published online June 11 in the Journal of Clinical Oncology.

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Genital Reconstruction Reduces Pain, Restores Pleasure

TUESDAY, June 12 (HealthDay News) -- Following female genital mutilation, reconstructive surgery is associated with improvements or no worsening in pain, and restoration of pleasure, for most women, according to a study published online June 12 in The Lancet.

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In Preemies, Maternal Smoking Tied to Necrotizing Enterocolitis

MONDAY, June 11 (HealthDay News) -- Maternal smoking has been identified as a risk factor associated with the development of necrotizing enterocolitis (NEC) in premature infants, according to a study published June 11 in Pediatrics.

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Many PCPs Recommend Colorectal Cancer Screening in Elderly

MONDAY, June 11 (HealthDay News) -- A substantial portion of primary care physicians (PCPs) recommend screening elderly patients with advanced cancer for colorectal cancer (CRC), according to a study published online June 1 in the Journal of General Internal Medicine.

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Gene Mutations May Predict Breast CA Treatment Response

MONDAY, June 11 (HealthDay News) -- Genetic mutations present in women with breast cancer may be able to predict whether the tumor will respond to treatment, according to a study published online June 10 in Nature.

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Sequencing of Cell-Free DNA Accurately IDs Trisomy Risk

FRIDAY, June 8 (HealthDay News) -- A noninvasive method involving chromosome-selective sequencing of cell-free DNA (cfDNA) and assessment of individual risk detects trisomy 18 and 21 with high sensitivity, according to a study published online June 4 in the American Journal of Obstetrics & Gynecology.

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Approximately 11 Percent of Global Live Births Are Preterm

FRIDAY, June 8 (HealthDay News) -- The global burden of preterm birth is considerable, representing 11.1 percent of all live births worldwide, according to a study published in the June 9 issue of The Lancet.

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Prevalence, Predictors of Interval Colorectal Cancer ID'd

FRIDAY, June 8 (HealthDay News) -- A variety of procedural and biologic factors contribute to the development of interval colorectal cancers, seen in 7.2 percent of Medicare beneficiaries, according to a study published in the June 15 issue of Cancer.

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Waist Size Independently Linked to Type 2 Diabetes Risk

FRIDAY, June 8 (HealthDay News) -- Waist circumference (WC) is independently associated with the risk of type 2 diabetes, and the association is particularly strong for women, according to a study published online June 5 in PLoS Medicine.

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Marker Helps Predict Thrombotic Risk of Hormonal Contraceptives

FRIDAY, June 8 (HealthDay News) -- For women taking hormonal contraceptives, sex hormone-binding globulin (SHBG) is a useful marker to estimate the risk of venous thrombosis, according to research published in the June issue of the Journal of Thrombosis and Haemostasis.

Abstract
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Cigarette Tax, Price Increases Reduce Smoking in Pregnancy

WEDNESDAY, June 6 (HealthDay News) -- Tobacco control policies, including taxation and price increases, and smoke-free policies are associated with a reduction in maternal smoking during pregnancy, according to a study published online June 5 in the American Journal of Preventive Medicine.

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Racial Gap in Life Expectancy Down From 2003 to 2008

WEDNESDAY, June 6 (HealthDay News) -- From 2003 to 2008, the gap in life expectancy between non-Hispanic blacks and whites in the United States decreased by about one year for both men and women, according to a research letter published in the June 6 issue of the Journal of the American Medical Association.

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Aspirin Ups Risk of Bleeding in All But Diabetes Patients

TUESDAY, June 5 (HealthDay News) -- Aspirin use is associated with an increased risk of major bleeding, while patients with diabetes have a high risk of bleeding, independent of aspirin use, according to a study published in the June 6 issue of the Journal of the American Medical Association.

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Gender Gap in Reproductive Preservation in Cancer Patients

TUESDAY, June 5 (HealthDay News) -- A gender gap exists in the manner in which young adult cancer patients are presented with fertility preservation options, with women reporting fewer discussions of future reproductive choices, according to a study published online May 30 in BJOG: An International Journal of Obstetrics and Gynaecology.

Abstract
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More Fruit, Veggies, Exercise Ups Survival in Older Women

MONDAY, June 4 (HealthDay News) -- Higher fruit and vegetable intake combined with exercise improves survival in older women, according to a study published in the May issue of the Journal of the American Geriatrics Society.

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Soy-Rich Diet Not Found to Improve Global Cognition

MONDAY, June 4 (HealthDay News) -- Long-term dietary supplementation with isoflavone-rich soy protein does not appear to improve the global cognition of healthy postmenopausal women, according to research published in the June 5 issue of Neurology.

Abstract
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Most Mothers Don't Reach Desired Breastfeeding Duration

MONDAY, June 4 (HealthDay News) -- Most mothers who want to exclusively breastfeed intend to do so for at least three months, but two-thirds of those who intend to breastfeed exclusively are not meeting their intended duration goals, according to a study published online June 4 in Pediatrics.

Abstract
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Acellular Dermal Matrix Safe, Useful in Breast Reconstruction

FRIDAY, June 1 (HealthDay News) -- Acellular dermal matrices provide good outcomes for patients undergoing breast reconstruction following mastectomy, but the human AlloDerm matrix has a higher seroma rate than porcine Strattice matrix, according to a study published in the June issue of Plastic and Reconstructive Surgery.

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Ischemic Stroke Risk Higher in Women With A-Fib

FRIDAY, June 1 (HealthDay News) -- Women with atrial fibrillation have a moderately higher risk of ischemic stroke than men, even after accounting for multiple cofactors for stroke, according to a study published online May 31 in BMJ.

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Editorial (subscription or payment may be required)

PTSD Linked to Urinary Incontinence in Female Veterans

FRIDAY, June 1 (HealthDay News) -- Posttraumatic stress disorder (PTSD) is independently associated with urgency/mixed urinary incontinence (UI) symptoms in female veterans, according to a study published in the June issue of the American Journal of Obstetrics & Gynecology.

Abstract
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