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Category: Pharmacy | Monthly Briefing

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June 2012 Briefing - Pharmacy

Last Updated: July 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for June 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Myrbetriq Approved for Overactive Bladder

FRIDAY, June 29 (HealthDay News) -- Myrbetriq (mirabegron) has been approved to treat adults with overactive bladder, a condition affecting some 33 million Americans, the U.S. Food and Drug Administration said Thursday in a news release.

overactive bladder

Hep B Screening Urged Before TNF-Alpha Inhibitor Therapy

FRIDAY, June 29 (HealthDay News) -- All patients with psoriasis should be screened for hepatitis B surface antigen and hepatitis B core antibody prior to the initiation of tumor necrosis factor-alpha inhibitor therapy, according to research published online June 25 in the Journal of the American Academy of Dermatology.

Abstract
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Nelarabine Plus Chemo Viable in Children With T-Cell ALL

FRIDAY, June 29 (HealthDay News) -- Treatment of children with newly-diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with nelarabine, in addition to an intensive Berlin-Frankfurt-Münster (BFM) 86-based chemotherapy regimen, is feasible and safe, according to a study published online June 25 in the Journal of Clinical Oncology.

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New Single Tablet for HIV Is Integrase Inhibitor Based

FRIDAY, June 29 (HealthDay News) -- For treatment-naive patients with HIV-1 infection, the once-daily tablet with HIV integrase strand transfer inhibitor elvitegravir (EVG), co-formulated with the CYP3A4 inhibitor cobicistat (COBI), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF), also known as EVG/COBI/FTC/TDF, is noninferior to a ritonavir-boosted (RTV) protease inhibitor regimen of atazanavir (ATV)/RTV+FTC/TDF, according to a phase 3 study published online June 29 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Aspirin Use Linked to Reduced Risk of Barrett's Esophagus

THURSDAY, June 28 (HealthDay News) -- Current aspirin users have a significantly reduced risk of being diagnosed with Barrett's esophagus (BE) on first endoscopy compared with nonusers, according to a study published in the July issue of Clinical Gastroenterology and Hepatology.

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Supreme Court Upholds Health Care Reform Law

THURSDAY, June 28 (HealthDay News) -- The U.S. Supreme Court voted June 28 to uphold the constitutionality of the Patient Protection and Affordable Care Act (PPACA), which has been the subject of debate and multiple lawsuits since its 2010 inception.

More Information

Omega-3 Supplements Reduce Inflammation in Overweight

THURSDAY, June 28 (HealthDay News) -- For older adults who are healthy but overweight and sedentary, taking omega-3 polyunsaturated fatty acids (PUFAs) can reduce levels of inflammatory markers, according to a study published online May 26 in Brain, Behavior, and Immunity.

Abstract
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FDA Clears First Weight-Loss Pill in 13 Years

THURSDAY, June 28 (HealthDay News) -- The Arena Pharmaceuticals drug Belviq (lorcaserin hydrochloride) has been approved by the U.S. Food and Drug Administration, the first approval of an anti-obesity medication in 13 years.

overweight and obesity

Linagliptin Noninferior to Glimepiride in Type 2 Diabetes

THURSDAY, June 28 (HealthDay News) -- The dipeptidyl peptidase-4 inhibitor linagliptin is noninferior to the sulphonylurea glimepiride for second-line glycemic control and is associated with significantly less hypoglycemia and fewer cardiovascular events in patients with type 2 diabetes, according to a study published online June 28 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Men and Women Appear to Respond Differently to Statins

WEDNESDAY, June 27 (HealthDay News) -- Statin therapy appears to reduce the risk of recurrent cardiovascular events in both men and women, but it may not reduce the risk of stroke or all-cause mortality in women, according to a meta-analysis published in the June 25 issue of the Archives of Internal Medicine.

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Duplicate Payments by Federal Government Increasing

WEDNESDAY, June 27 (HealthDay News) -- The federal government spends a substantial and increasing amount on individuals who are dually enrolled in separate managed care programs (the Veterans Affairs health care system [VA] and Medicare Advantage plan [MA]), according to a study published online June 26 in the Journal of the American Medical Association to coincide with presentation at the Annual Research Meeting of AcademyHealth, held from June 24 to 26 in Orlando, Fla.

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Warfarin Safe After Ischemic Stroke in tPA-Treated Patients

TUESDAY, June 26 (HealthDay News) -- For patients receiving tissue plasminogen activator (tPA) after ischemic stroke, warfarin has no effect on the risk of symptomatic intracranial hemorrhage (sICH), according to a study published in the June 27 issue of the Journal of the American Medical Association.

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Limited Radiation Acceptable in Pediatric Hodgkin's Lymphoma

TUESDAY, June 26 (HealthDay News) -- For patients with favorable-risk Hodgkin's lymphoma who achieve a complete early response to chemotherapy with vinblastine, Adriamycin (doxorubicin), methotrexate, and prednisone (VAMP), two-year event-free survival rates are high with limited use of radiotherapy, according to a study published in the June 27 issue of the Journal of the American Medical Association.

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Use of Electronic Records Tied to Fewer Malpractice Claims

TUESDAY, June 26 (HealthDay News) -- Use of electronic health records (EHRs) is associated with fewer medical malpractice claims among physicians from multiple surgical and medical specialties, according to a research letter published online June 25 in the Archives of Internal Medicine.

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Olmesartan May Be Linked to Spruelike Enteropathy

TUESDAY, June 26 (HealthDay News) -- Patients treated with olmesartan may develop a severe form of spruelike enteropathy, which improves after suspension of the drug, according to research published online June 25 in the Mayo Clinic Proceedings.

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Steroid-Free Regimen Post-Pediatric Renal Transplant Safe

TUESDAY, June 26 (HealthDay News) -- A steroid-free approach to immunosuppression following pediatric renal transplants is safe and effective, according to a study published online June 13 in the American Journal of Transplantation.

Abstract
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Early Vaccinations Not Linked to Celiac Disease in Sweden

MONDAY, June 25 (HealthDay News) -- Early vaccinations do not seem to influence the risk of celiac disease (CD) among infants, nor do changes in the vaccination program explain the CD epidemic, according to a Swedish study published online June 25 in Pediatrics.

Abstract
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Advanced BRAF V600E Melanoma Responds to Dabrafenib

MONDAY, June 25 (HealthDay News) -- Patients with BRAF V600E-mutated metastatic melanoma treated with dabrafenib, an inhibitor of mutated BRAF, have significantly improved progression-free survival compared to those treated with dacarbazine, according to a study published online June 25 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Early Start to ADHD Meds Lowers Risk of Academic Decline

MONDAY, June 25 (HealthDay News) -- Earlier initiation of stimulant treatment for attention-deficit/hyperactivity disorder (ADHD) is associated with a lower risk of decline in academic performance, according to a study published online June 25 in Pediatrics.

Abstract
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Genetic Contribution Detected in Responses to Opioids

THURSDAY, June 21 (HealthDay News) -- The responses to opioid drugs, such as nausea, respiratory depression, and drug liking or disliking, have a significant inherited component, according to a study published in the July issue of Anesthesiology.

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Multi-Drug Regimens Cut HIV Transmission Versus Zidovudine

WEDNESDAY, June 20 (HealthDay News) -- For infants of mothers with HIV who did not receive antenatal antiretroviral therapy (ART), treatment with two or three drugs reduces transmission compared with zidovudine alone; and more infants treated with nevirapine together with zidovudine and lamivudine have virologic failure by six months, according to two studies published in the June 21 issue of the New England Journal of Medicine.

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Research Suggests Flavocoxid Causes Acute Liver Injury

TUESDAY, June 19 (HealthDay News) -- Flavocoxid, a proprietary prescription medical food used to treat osteoarthritis, appears to cause acute liver injury within months of initiating use, according to research published in the June 19 issue of the Annals of Internal Medicine.

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Editorial (subscription or payment may be required)

Belimumab Deemed Safe for Long-Term Lupus Treatment

TUESDAY, June 19 (HealthDay News) -- For patients with systemic lupus erythematosus (SLE), long-term belimumab therapy combined with standard therapy is well tolerated, according to a study published online June 5 in Arthritis & Rheumatism.

Abstract
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Genetic Variants Predict Outcomes After t-PA Treatment

MONDAY, June 18 (HealthDay News) -- Two genetic variants have been identified that are associated with hemorrhagic transformation (HT) and mortality rates after infusion of tissue plasminogen activator (t-PA) in patients with acute ischemic stroke, according to research published online June 9 in the Annals of Neurology.

Abstract
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A Shift in Pediatric Drug Utilization Seen 2002 to 2010

MONDAY, June 18 (HealthDay News) -- From 2002 to 2010 there was a 7 percent decrease in outpatient pediatric prescription medication utilization, due in part to a decrease in antibiotics and allergy medication prescriptions, according to a study published online June 18 in Pediatrics.

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Review: Vitamin D Plus Calcium Linked to Mortality Reduction

FRIDAY, June 15 (HealthDay News) -- Analyses of data from individual patients and trials indicate that vitamin D supplementation in combination with calcium is linked to a reduction in mortality for elderly adults, but this effect is not seen for vitamin D alone, according to research published online May 17 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Menhibrix Approved to Prevent Bacterial Infections in Infants

FRIDAY, June 15 (HealthDay News) -- The combination vaccine Menhibrix has been approved by the U.S. Food and Drug Administration to prevent two deadly bacterial infections among infants and toddlers -- Neisseria meningitides serogroups C and Y and Haemophilus influenzae type b.

FDA

Testosterone Therapy Does Not Up Prostate Cancer Incidence

FRIDAY, June 15 (HealthDay News) -- Testosterone replacement therapy (TRT) appears to be safe and does not increase the incidence of prostate cancer, according to a study published online June 6 in The Journal of Sexual Medicine.

Abstract
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Mental Health Disorders Up Long-Term Opioid Use in Youth

THURSDAY, June 14 (HealthDay News) -- When presenting with a new episode of chronic pain, the presence of preexisting mental health disorders is associated with an increased risk of long-term opioid pain use, according to a study published in the June issue of the Journal of Adolescent Health.

Abstract
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Cognitive Benefit of Omega-3s in Older Adults Questioned

THURSDAY, June 14 (HealthDay News) -- Omega-3 long-chain polyunsaturated fatty acids (PUFA) supplementation has no benefit on cognitive function in cognitively healthy older people, according to a review published online June 13 in The Cochrane Library.

Abstract
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Statins Exhibit Adverse Effect on Energy, Exertional Fatigue

THURSDAY, June 14 (HealthDay News) -- For relatively healthy individuals, particularly women, statin use may be associated with reduced energy and exertional fatigue, according to a research letter published online June 11 in the Archives of Internal Medicine.

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Ethinyl Estradiol Dose, Progestin Type Affect the Pill's Stroke Risk

WEDNESDAY, June 13 (HealthDay News) -- The risk of thrombotic stroke and myocardial infarction is increased for women who take oral contraceptives that include ethinyl estradiol, with the relative risk varying according to the dose of ethinyl estradiol and the progestin type, according to a study published in the June 14 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Curbing Antibiotic Prophylaxis Doesn't Up Endocarditis Risk

WEDNESDAY, June 13 (HealthDay News) -- The incidence of viridans group streptococci infective endocarditis (VGS-IE) has not increased since the publication of the 2007 American Heart Association (AHA) guidelines restricting prophylactic antibiotics in dental patients, according to a study published online June 11 in Circulation.

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Changes in Tumor Size by RECIST Correlate With Survival

WEDNESDAY, June 13 (HealthDay News) -- RECIST categories used to quantify tumor changes during exposure to anticancer therapies correlate well with overall survival (OS) but reflect a more linear continuum without clear inflection points, according to a study published online June 11 in the Journal of Clinical Oncology.

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In Vitro Fertilization Linked to Multiple Sclerosis Relapse

WEDNESDAY, June 13 (HealthDay News) -- Women with multiple sclerosis (MS) who undergo in vitro fertilization (IVF) are at greater risk of relapse after treatment, particularly if they receive gonadotrophin releasing hormone (GnRH) agonists or if IVF fails, according to a study published online June 11 in the Journal of Neurology, Neurosurgery & Psychiatry.

Abstract
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Cannabinoid Formulation Benefits Opioid-Refractory Pain

WEDNESDAY, June 13 (HealthDay News) -- A novel cannabinoid formulation, nabiximols, is safe and effective for patients with advanced cancer and opioid-refractory pain, especially at a low-dose, according to a study published in the May issue of The Journal of Pain.

Abstract
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Life-Long Rx Not Always Needed for Juvenile Myoclonic Epilepsy

WEDNESDAY, June 13 (HealthDay News) -- Juvenile myoclonic epilepsy (JME) is a heterogeneous epilepsy syndrome and life-long antiepileptic drug (AED) treatment is not required in all patients to maintain seizure freedom, according to a study published online June 12 in Epilepsia.

Abstract
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Task Force Questions Use of Vitamin D, Calcium Supplements

TUESDAY, June 12 (HealthDay News) -- Current evidence is insufficient to support the use of vitamin D and calcium supplements to protect against cancer or osteoporotic fractures, according to a draft recommendation issued by the U.S. Preventive Services Task Force (USPSTF).

Draft Recommendation Statement

Perjeta Approved for Advanced Breast Cancer

TUESDAY, June 12 (HealthDay News) -- Perjeta (pertuzumab) has been approved by the U.S. Food and Drug Administration to treat people with HER2-positive late-stage breast cancer, the agency said in a news release.

this approval

Gender Gap Exists in Physician Researchers' Salaries

TUESDAY, June 12 (HealthDay News) -- A survey of mid-career academic physician researchers shows that gender differences in salary exist even after adjusting for differences in specialty, institutional characteristics, academic productivity, academic rank, and work hours, according to a study published in the June 13 issue of the Journal of the American Medical Association.

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Thiazolidinedione Use Linked to Diabetic Macular Edema

MONDAY, June 11 (HealthDay News) -- Treatment with a thiazolidinedione is associated with an increased one- and 10-year risk of diabetic macular edema (DME) in patients with type 2 diabetes, according to a study published online June 11 in the Archives of Internal Medicine.

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Higher Risk of VTE in CKD Surgical Patients on Enoxaparin

FRIDAY, June 8 (HealthDay News) -- For patients with chronic kidney disease (CKD) who undergo total hip replacement (THR), the rate of major venous thromboembolism (VTE) is significantly higher in those treated with enoxaparin compared to those treated with desirudin, according to a study published online June 4 in the Journal of Thrombosis and Haemostasis.

Abstract
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Marker Helps Predict Thrombotic Risk of Hormonal Contraceptives

FRIDAY, June 8 (HealthDay News) -- For women taking hormonal contraceptives, sex hormone-binding globulin (SHBG) is a useful marker to estimate the risk of venous thrombosis, according to research published in the June issue of the Journal of Thrombosis and Haemostasis.

Abstract
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Intranasal Insulin Linked to Reduced Food Intake

THURSDAY, June 7 (HealthDay News) -- Intranasally administered insulin is associated with higher brain energy levels and reduced calorie intake, according to a study published online May 14 in Diabetes.

Abstract
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Vismodegib Has Antitumor Activity in Basal Cell Carcinoma

WEDNESDAY, June 6 (HealthDay News) -- A small-molecule inhibitor of the hedgehog pathway, vismodegib, is associated with tumor response in patients with metastatic or locally advanced basal cell carcinoma (BCC); and vismodegib is efficacious for preventing and treating BCCs in patients with basal cell nevus syndrome, according to two studies published in the June 7 issue of the New England Journal of Medicine.

Full Text - Sekulic (subscription or payment may be required)
Full Text - Tang (subscription or payment may be required)
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Multidrug-Resistance Seen in ~10 Percent of TB Cases in China

WEDNESDAY, June 6 (HealthDay News) -- About one in 10 patients with tuberculosis in China has multidrug-resistant (MDR) tuberculosis; and a new drug, delamanid, is significantly better than placebo for increasing sputum-culture conversion at two months in patients with MDR tuberculosis, according to two studies published in the June 7 issue of the New England Journal of Medicine.

Full Text - Zhao (subscription or payment may be required)
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Many Adults May Accidentally Overdose on Acetaminophen

WEDNESDAY, June 6 (HealthDay News) -- About a quarter of adults may accidentally overdose on over-the-counter (OTC) acetaminophen-containing products, and almost half overdose by "double-dipping" with two acetaminophen-containing products, according to a study published online May 26 in the Journal of General Internal Medicine.

Abstract
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Anti-HTN Drugs Have Distinct Effect on Central, Brachial SBP

WEDNESDAY, June 6 (HealthDay News) -- A reduction in central to brachial amplification induced by some antihypertensive drugs may result in lesser reductions in central than brachial systolic blood pressure, according to research published online May 25 in the British Journal of Clinical Pharmacology.

Abstract
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Aspirin Ups Risk of Bleeding in All But Diabetes Patients

TUESDAY, June 5 (HealthDay News) -- Aspirin use is associated with an increased risk of major bleeding, while patients with diabetes have a high risk of bleeding, independent of aspirin use, according to a study published in the June 6 issue of the Journal of the American Medical Association.

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In A-Fib, Rhythm Control Reduces Mortality in Long Term

TUESDAY, June 5 (HealthDay News) -- Elderly patients with atrial fibrillation have reduced mortality over the long term if they initiate rhythm control treatment rather than rate control treatment, according to a study published online June 4 in the Archives of Internal Medicine.

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Many Patients Keep Using PPIs After Negative GERD Test

TUESDAY, June 5 (HealthDay News) -- Nearly half of patients continue to use proton pump inhibitors (PPIs) even after pH studies confirm that they do not have gastroesophageal reflux disease (GERD), and most do not recall being instructed to stop taking PPIs, according to a study published in the June issue of Clinical Gastroenterology and Hepatology.

Abstract
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Management of Acetaminophen Overdose in Children Reviewed

TUESDAY, June 5 (HealthDay News) -- Due to the widespread use of acetaminophen, overdose is a concern, particularly for infants and children, who have developmental differences in their hepatic metabolism that affect hepatotoxicity, according to a review published online June 4 in CMAJ, the journal of the Canadian Medical Association.

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Head Lice Beginning to Show Permethrin Resistance

TUESDAY, June 5 (HealthDay News) -- Although live head lice obtained from school-aged children in Paris remain susceptible to the insecticide malathion, approximately 14 percent have been found to be resistant to permethrin, suggesting a strong basis for future insecticide resistance, according to research published online May 24 in the Journal of the American Academy of Dermatology.

Abstract
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Gene Variants Impact Smokers' Response to Cessation Therapy

FRIDAY, June 1 (HealthDay News) -- Smokers with certain high-risk genetic variants find it more difficult to quit smoking but are more likely to respond to cessation pharmacotherapy, according to a study published online May 30 in the American Journal of Psychiatry.

Abstract
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Pioglitazone Use Ups Bladder Cancer Risk in Type 2 Diabetes

FRIDAY, June 1 (HealthDay News) -- For patients with type 2 diabetes, use of the oral hypoglycemic agent pioglitazone correlates with an increased risk of bladder cancer, with the risk increasing with duration of use, according to a study published online May 31 in BMJ.

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Editorial (subscription or payment may be required)

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