Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Family Medicine | Nursing | ENT | Pathology | Allergy | Journal

Back to Journal Articles

Free Light Chains Identified in Chronic Rhinosinusitis

Last Updated: July 16, 2012.

 

Increased concentration of free light chains most prominent in those with nasal polyps

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Patients with chronic rhinosinusitis (CRS) have increased free light chain concentrations, particularly those with CRS with nasal polyps, according to a study published online July 5 in Allergy.

MONDAY, July 16 (HealthDay News) -- Patients with chronic rhinosinusitis (CRS) have increased free light chain (FLC) concentrations, particularly those with CRS with nasal polyps (CRSwNP), according to a study published online July 5 in Allergy.

Tom Groot Kormelink, of Utrecht University in the Netherlands, and associates analyzed nasal tissue, nasal secretion, and serum of patients with CRSwNP and CRS without nasal polyps (CRSsNP) to determine the presence of FLCs. The effect of different treatments on the expression of FLCs was examined.

The researchers found that patients with CRS had increased FLC concentrations in nasal secretion and mucosal tissue homogenates, and the increase was most prominent in patients with CRSwNP. The increase in FLC in nasal polyp tissue was confirmed by immunohistochemistry. Treatment with methylprednisolone or anti-interleukin-5 (IL-5) resulted in the reduction in systemic or local FLC concentrations, respectively, in patients with CRSwNP.

"The presence of FLC in CRSwNP and CRSsNP suggests a possible role in mediating the local immune reaction in the paranasal cavities," the authors write. "Furthermore, the decrease in local FLCs after treatment with anti-IL-5 presumes that IL-5 creates an environment that favors FLC production."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Factors Influencing Hepatitis C RNA Levels in Drug Users ID'd Next: Dental Composite Affects Child Psychosocial Functioning

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.