Create Account | Sign In: Author or Forum

News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    



Category: Family Medicine | Infections | AIDS | Nursing | Pathology | Pharmacy | Journal

Back to Journal Articles

HIV Drug-Resistance Up in Resource-Limited Settings

Last Updated: July 23, 2012.


Increase in prevalence since antiretroviral rollout in regions of sub-Saharan African

Share |

Comments: (0)



In resource-limited settings, the prevalence of HIV-1 drug resistance has increased since antiretroviral rollout, according to a study published online July 23 in The Lancet.

MONDAY, July 23 (HealthDay News) -- In resource-limited settings, the prevalence of HIV-1 drug resistance has increased since antiretroviral rollout, according to a study published online July 23 in The Lancet.

Ravindra K. Gupta, M.R.C.P., from the University College London, and colleagues conducted a systematic review and meta-analysis to estimate changes in the prevalence of HIV-1 drug resistance in treatment-naive individuals with HIV in resource-limited settings, with respect to time since antiretroviral rollout.

The researchers identified study-level data for 26,106 patients from sub-Saharan Africa, Asia, and Latin America. There were no differences in the prevalence of one or more drug-resistance mutations for any region between chronic and recent infection. The highest estimated rate of increase was 29 percent per year since rollout, noted in east Africa, with an estimated prevalence of HIV-1 drug resistance of 7.4 percent at eight years after rollout. There was an annual increase of 14 percent in southern African and nonsignificant 3 percent increases in west and central Africa. In Latin American there was no change in resistance over time and, due to country-level heterogeneity, the meta-regression analysis was not appropriate for Asia. In east and southern Africa there were significant increases in resistance to non-nucleoside reverse transcriptase inhibitors, with no increase for other drug classes in any region.

"Now, more than ever, investment and political will are urgently needed to sustain and expand global surveillance efforts," the authors write. "Such investments are essential to maximize the effectiveness of treatment scale-up."

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Previous: HIV Doesn't Impact Cervical Cancer Risk in HPV-Negative Next: Modest Prediction of Preterm Birth Using Clinical Features

Reader comments on this article are listed below. Review our comments policy.

Submit your opinion:





Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application


 advertisement.gif (61x7 -- 0 bytes)



Useful Sites
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.