Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Family Medicine | Infections | Nursing | Pediatrics | Pharmacy | Journal

Back to Journal Articles

Higher Rates of Pertussis With Acellular Pertussis Vaccine

Last Updated: July 31, 2012.

 

Children who receive mixed dose of DTaP and DTwP have higher rate if their first dose was DTaP

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Children who receive acellular pertussis vaccines have higher rates of pertussis compared with those receiving whole cell pertussis vaccines, according to a research letter published in the Aug. 1 issue of the Journal of the American Medical Association.

TUESDAY, July 31 (HealthDay News) -- Children who receive acellular pertussis vaccines have higher rates of pertussis compared with those receiving whole cell pertussis vaccines, according to a research letter published in the Aug. 1 issue of the Journal of the American Medical Association.

Sarah L. Sheridan, B.Med., M.App.Epid., from the Queensland Children's Medical Research Institute in Brisbane, Australia, and colleagues examined whether the sustained pertussis epidemic experienced in Australia was related to the 1999 replacement of diphtheria-tetanus-whole cell pertussis (DTwP) with acellular pertussis (diphtheria-tetanus-acellular pertussis [DTaP]) vaccines, which have a lower rate of adverse events. Pertussis reporting rates were compared with primary course vaccination for 58,233 children in the 1998 birth cohort, of whom 69.5 percent received at least three doses of any pertussis-containing vaccine during the first year.

The researchers found that, in the pre-epidemic and outbreak periods, children who received a three-dose DTaP had higher rates of pertussis compared with those who received a three-dose DTwP primary course. For those who received a mixed dose, rates in the current epidemic were highest for children who received DTaP as their first dose. The incidence rates for children who received a mixed course with DTwP as the initial dose were between rates for the pure course DTwP and DTaP cohorts.

"The challenge for future pertussis vaccine development is to address the benefit-risk trade-off highlighted by our study, and to develop vaccines that induce long-lasting protection from the first dose, without the adverse events associated with DTwP use," the authors write.

Two authors disclosed financial ties to GlaxoSmithKline and sanofi-pasteur, both of which manufacture pertussis-containing vaccines.

Full Text

Copyright © 2012 HealthDay. All rights reserved.


Previous: Lymphoid Neogenesis Identified in Melanoma Metastases Next: Levels of Etonogestrel Lower in Obese Women After Implant

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.