Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for July 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Varied Mutation Prevalence in Multiple Colorectal Adenomas
TUESDAY, July 31 (HealthDay News) -- For patients with multiple colorectal adenomas there is considerable heterogeneity in the prevalence of pathogenic APC and MUTYH mutations, which varies by adenoma count, according to a study published in the Aug. 1 issue of the Journal of the American Medical Association.
Celiac Disease Linked to Lymphoproliferative Disorders
THURSDAY, July 26 (HealthDay News) -- Patients with celiac disease, particularly those presenting with malabsorption symptoms later in life, have a higher incidence of lymphoproliferative disorders (LPDs), according to research published in the August issue of the American Journal of Hematology.
Selenium, Vitamins C, E May Lower Pancreatic Cancer Risk
THURSDAY, July 26 (HealthDay News) -- Higher intakes of the antioxidants selenium and vitamins C and E reduce the risk of pancreatic cancer by two-thirds, according to a study published online July 23 in Gut.
Vitamin E Intake Inversely Linked to Liver Cancer Risk
WEDNESDAY, July 25 (HealthDay News) -- Evidence suggests that vitamin E in the diet or from supplements may reduce the risk of developing liver cancer in men and women, according to research published online July 17 in the Journal of the National Cancer Institute.
Study Supports Longer Scope Intervals Post-Polypectomy
MONDAY, July 23 (HealthDay News) -- For individuals who have had at least one adenoma removed at colonoscopy, the risk of developing colorectal cancer is greatly reduced up to five years later, according to a study published online June 23 in the Journal of Clinical Oncology.
Vitamin B12 Improves Viral Response in Chronic Hepatitis C
FRIDAY, July 20 (HealthDay News) -- Vitamin B12 supplementation significantly improves the rate of sustained viral response (SVR) to pegylated interferon-α and ribavirin in patients with chronic hepatitis C virus (HCV) infection naive to antiviral therapy, according to a study published online July 17 in Gut.
Most Doctors Satisfied With Electronic Health Records
THURSDAY, July 19 (HealthDay News) -- Although only 55 percent of physicians had adopted electronic health records (EHRs) in 2011, most are somewhat or very satisfied with their system and most report enhanced patient care, according to a July data brief issued by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).
Poorer Patient Experience at Safety-Net Hospitals
THURSDAY, July 19 (HealthDay News) -- Safety-net hospitals (SNHs) perform worse on nearly every measure of patient experience, according to a study published online July 16 in the Archives of Internal Medicine.
~12,000 Preventable Deaths in English Hospitals Annually
THURSDAY, July 19 (HealthDay News) -- Approximately 12,000 hospital deaths in England each year are preventable, according to research published online July 7 in BMJ Quality & Safety.
Another New Weight-Loss Drug Approved
WEDNESDAY, July 18 (HealthDay News) -- Qsymia (phentermine and topiramate extended-release) has been approved by the U.S. Food and Drug Administration, making it the second weight-loss drug to be given the agency's green light in less than a month.
Milk Thistle Not Effective for Refractory Chronic Hepatitis C
WEDNESDAY, July 18 (HealthDay News) -- Use of the milk thistle extract silymarin does not provide additional benefit compared with placebo for patients with treatment-resistant chronic hepatitis C virus (HCV), according to a study published in the July 18 issue of the Journal of the American Medical Association.
Smoking Ups Recurrent Viral Hepatitis Post-Liver Transplant
WEDNESDAY, July 18 (HealthDay News) -- For liver transplant recipients, smoking correlates with an increased risk of recurrent viral hepatitis, according to a study published in the July issue of Liver Transplantation.
Bariatric Surgery Does Not Reduce Health Care Expenses
WEDNESDAY, July 18 (HealthDay News) -- In a group of older men with substantial disease burden, bariatric surgery is not associated with reduced health care expenditures within three years of surgery, according to research published in the July issue of the Archives of Surgery.
New Drug Approved for Colonoscopy Preparation
TUESDAY, July 17 (HealthDay News) -- Prepopik (sodium picosulfate, magnesium oxide, and citric acid) has been approved by the U.S. Food and Drug Administration for adults preparing for a colonoscopy, a diagnostic procedure to inspect the colon's inner lining.
Social Network Analysis IDs Informal Physician Networks
TUESDAY, July 17 (HealthDay News) -- Informal networks among physicians who share patients demonstrate substantial geographic variability, while within networks, physician and patient characteristics are similar, according to a study published in the July 18 issue of the Journal of the American Medical Association.
Gut Microbiota Correlate With Diet, Health in Elderly
TUESDAY, July 17 (HealthDay News) -- Analysis of gut microbiota from elderly individuals shows distinct groups that correlate with measures of health, including frailty and markers of inflammation, according to a study published online July 13 in Nature.
Induction Chemo Beneficial in Locally Advanced Pancreatic CA
TUESDAY, July 17 (HealthDay News) -- For most patients with locally advanced pancreatic carcinoma (LAPC), induction with a combination of gemcitabine and oxaliplatin (GEMOX) followed by chemoradiotherapy (CRT) is feasible, resulting in clinical benefit, a chance of resectability, and improved survival, according to a study published online July 6 in Cancer.
Shorter Scope Interval Supported for Better CA Stage at Diagnosis
MONDAY, July 16 (HealthDay News) -- There is a significant benefit in the cancer stage at diagnosis for patients who undergo endoscopy screening, with similar benefits seen for intervals of one, two, and three years, according to a study published online July 16 in Cancer.
Factors Influencing Hepatitis C RNA Levels in Drug Users ID'd
MONDAY, July 16 (HealthDay News) -- Levels of hepatitis C virus (HCV) RNA in injection drug users are independently associated with various demographic, viral, and host genetic factors, including being older, male, African-American, and co-infected with HIV, according to a study published in the July issue of Hepatology.
Chemo Combo Promising for Pancreatic Neuroendocrine Tumors
FRIDAY, July 13 (HealthDay News) -- The combination of temozolomide and bevacizumab seems to benefit patients with advanced pancreatic neuroendocrine tumors (NETs), according to a study published online July 9 in the Journal of Clinical Oncology.
Study Supports Chemo After Periampullary Cancer Surgery
TUESDAY, July 10 (HealthDay News) -- After adjusting for prognostic variables, patients who receive adjuvant chemotherapy following resection of periampullary adenocarcinomas have improved survival compared with those who receive only observation, according to a study published in the July 11 issue of the Journal of the American Medical Association.
GI Cancer Resection OK With Mild Cirrhotic Liver Dysfunction
TUESDAY, July 10 (HealthDay News) -- For patients with cirrhosis, resection of gastrointestinal (GI) malignancies correlates with poor early postoperative outcomes, with severity of liver disease being the primary determinant of postoperative mortality, according to a study published in the July issue of Cancer.
New Test Helps Evaluate Erbitux's Merit
MONDAY, July 9 (HealthDay News) -- A new genetic test to help doctors determine if the drug Erbitux would be an effective treatment for certain colorectal cancer patients has been approved by the U.S. Food and Drug Administration.
Nonnutritive Sweetener Role in Cutting Sugar Intake Explored
MONDAY, July 9 (HealthDay News) -- Although the evidence is limited, nonnutritive sweeteners (NNS) have a potential role to play in facilitating reduction of added sugar intake, as long as they do not cause a compensatory increase in energy intake, according to a new scientific statement issued by the American Heart Association and the American Diabetes Association and published online July 9 in Circulation.
Gastrointestinal Perforation Rare in Rheumatoid Arthritis
FRIDAY, July 6 (HealthDay News) -- Gastrointestinal (GI) perforation is a rare but serious condition that affects patients with rheumatoid arthritis (RA), most frequently in the lower GI tract, according to a study published online June 21 in Arthritis Care & Research.
Dose-Escalated Cetuximab Tolerated in Colorectal Cancer
THURSDAY, July 5 (HealthDay News) -- For patients with irinotecan-refractory metastatic colorectal cancer (CRC), dose escalation of cetuximab is well tolerated and may improve response and disease control rates, but patients experience more grade ≥2 skin reactions, according to a study published online July 2 in the Journal of Clinical Oncology.
CT Colonography Is a Viable Screening Test in Older Adults
MONDAY, July 2 (HealthDay News) -- For older patients who undergo computed tomography colonography (CTC), the rates of referral to colonoscopy and prevalence of advanced neoplasia are low, according to a study published in the July issue of the American Journal of Roentgenology.
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