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Category: Pathology | Monthly Briefing

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July 2012 Briefing - Pathology

Last Updated: August 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pathology for July 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Lymphoid Neogenesis Identified in Melanoma Metastases

TUESDAY, July 31 (HealthDay News) -- Lymphoid follicles, comprising clusters of B lymphocytes and follicular dendritic cells (DCs) associated with high endothelial venules (HEVs), are found in melanoma metastases, but not in primary melanomas, according to a study published online July 31 in Cancer Research.

Abstract
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Varied Mutation Prevalence in Multiple Colorectal Adenomas

TUESDAY, July 31 (HealthDay News) -- For patients with multiple colorectal adenomas there is considerable heterogeneity in the prevalence of pathogenic APC and MUTYH mutations, which varies by adenoma count, according to a study published in the Aug. 1 issue of the Journal of the American Medical Association.

Abstract
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Editorial

No Link Between Telomere Length and Diabetes Risk

TUESDAY, July 31 (HealthDay News) -- Leukocyte telomere length is not independently associated with type 2 diabetes risk in postmenopausal women, according to a study published online July 24 in Diabetes.

Abstract
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Cases of Delayed Anaphylaxis to Red Meat Described

TUESDAY, July 31 (HealthDay News) -- Individuals who have been bitten by the lone star tick may develop immunoglobulin E (IgE) to the carbohydrate galactose-α-1,3-galactose (alpha-gal), which puts them at risk for delayed anaphylaxis after consumption of meat containing alpha-gal on glycoproteins or glycolipids, according to a study published online July 20 in the Journal of General Internal Medicine.

Abstract
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Energy-Saving Light Bulbs May Be Harmful to Human Skin

MONDAY, July 30 (HealthDay News) -- Energy-saving compact fluorescent light bulbs emit ultraviolet radiation and may have damaging effects on skin cells, according to a study published online July 20 in Photochemistry and Photobiology.

Abstract
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Prior Basal Cell Carcinoma Is Main Predictor of Future BCC

MONDAY, July 30 (HealthDay News) -- Prior basal cell carcinoma (BCC) is the greatest predictor of future incidence of BCC, according to a study published online July 19 in the Journal of Investigative Dermatology.

Abstract
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Photochemical Restores Light Sensitivity in Blind Mice

MONDAY, July 30 (HealthDay News) -- A small molecule "photoswitch," AAQ, restores light sensitivity in mouse models of degenerative eye diseases, according to a study published in the July 26 issue of Neuron.

Abstract
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Histological Subtype Impacts Survival in Renal Cell Cancer

MONDAY, July 30 (HealthDay News) -- The histological subtype of renal cell carcinoma (RCC) impacts both overall and cancer-specific survival, according to a study published in the August issue of The Journal of Urology.

Abstract
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Lymphovascular Invasion Is Independent Predictor of Survival

FRIDAY, July 27 (HealthDay News) -- In patients with invasive breast cancer, lymphovascular invasion (LVI) is a strong and independent predictor of both breast cancer-specific survival (BCSS) and distant metastasis-free survival (DMFS), according to a study published in the Aug. 1 issue of Cancer.

Abstract
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MRSA Skin Infections Up, Linked to Furunculosis

FRIDAY, July 27 (HealthDay News) -- The incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in the United States is increasing and is associated with follicular infection, most commonly folliculitis followed by furunculosis, according to a review published online July 16 in the British Journal of Dermatology.

Abstract
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Study Highlights Importance of 'Good' Skin Bacteria in Immunity

FRIDAY, July 27 (HealthDay News) -- Similar to the gut, commensal bacteria in the skin are important for protective T cell-based immunity, according to a study published online July 26 in Science.

Abstract
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Brain Glucose in Steady-State During Hypoglycemia

THURSDAY, July 26 (HealthDay News) -- The plasma-to-brain glucose relationship and the calculations demonstrating glucose transport over the blood-brain barrier do not differ between healthy subjects and patients with uncomplicated, reasonably well-controlled type 1 diabetes mellitus (T1DM), according to a study published in the August issue of Diabetes.

Abstract
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Excess Maternal Iodine Linked to Congenital Hypothyroidism

THURSDAY, July 26 (HealthDay News) -- Excess maternal iodine supplementation can result in congenital hypothyroidism, according to a study published online July 26 in The Journal of Pediatrics.

Full Text

Selenium, Vitamins C, E May Lower Pancreatic Cancer Risk

THURSDAY, July 26 (HealthDay News) -- Higher intakes of the antioxidants selenium and vitamins C and E reduce the risk of pancreatic cancer by two-thirds, according to a study published online July 23 in Gut.

Abstract
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Stability of Fragrance Patch Test Preparations Examined

THURSDAY, July 26 (HealthDay News) -- Concentrations of several fragrance allergens applied to test chambers well in advance of patient testing may be reduced by 20 percent or more within hours when stored at room temperature, according to a study published online July 14 in the British Journal of Dermatology.

Abstract
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Vitamin E Intake Inversely Linked to Liver Cancer Risk

WEDNESDAY, July 25 (HealthDay News) -- Evidence suggests that vitamin E in the diet or from supplements may reduce the risk of developing liver cancer in men and women, according to research published online July 17 in the Journal of the National Cancer Institute.

Abstract
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Shortened Telomere Length Tied to Dementia, Mortality Risk

WEDNESDAY, July 25 (HealthDay News) -- Shortened telomere length (TL) is associated with risks for dementia and mortality in a population of older adults, according to a study published online July 23 in the Archives of Neurology.

Abstract
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Lipid Storage Protein Linked to Insulin Sensitivity

TUESDAY, July 24 (HealthDay News) -- Perilipin 2 (PLIN2) plays a role in regulating lipid storage in skeletal muscle and can improve insulin sensitivity, according to a study published online July 17 in Diabetes.

Abstract
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Infants at Greatest Risk in 2010 California Pertussis Epidemic

FRIDAY, July 20 (HealthDay News) -- In the 2010 California pertussis epidemic, all deaths and most hospitalizations occurred in infants younger than 3 months of age, according to research published online July 19 in the Journal of Pediatrics.

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HIV Drug-Resistance Up in Resource-Limited Settings

MONDAY, July 23 (HealthDay News) -- In resource-limited settings, the prevalence of HIV-1 drug resistance has increased since antiretroviral rollout, according to a study published online July 23 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

'Genetic Score' May Improve Prostate Cancer Prediction

MONDAY, July 23 (HealthDay News) -- A genetic score can modestly improve the prediction of which men are likely to have positive biopsies for prostate cancer after an initial negative biopsy, according to a study published online May 16 in European Urology.

Abstract
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Genetic Evidence Identified for Role of IDO in Tumorigenesis

MONDAY, July 23 (HealthDay News) -- Mice deficient in indoleamine 2,3-dioxygenase (IDO) have reduced tumor burden and improved survival, with greatly attenuated interleukin-6 (IL-6) and impaired protumorigenic myeloid-derived suppressor cells (MDSC) seen in conjunction with the loss of IDO, according to a study published online July 19 in Cancer Discovery.

Abstract
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Heart Medication Converts Cancer Cells Into Vaccine

FRIDAY, July 20 (HealthDay News) -- A class of heart medications, cardiac glycosides, can induce immunogenic cell death (ICD), whereby dying cancer cells are converted into a vaccine that stimulates antitumor response, according to a study published in the July 18 issue of Science Translational Medicine.

Abstract
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HIV Racial Disparities Noted for Men Who Have Sex With Men

FRIDAY, July 20 (HealthDay News) -- Similar racial disparities are seen in HIV infection for men who have sex with men (MSM) in the United States and the United Kingdom, according to a study published online July 20 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Similar Genetic Alterations in Most Colon, Rectal Cancers

FRIDAY, July 20 (HealthDay News) -- About 85 percent of colon and rectal cancers are very similar in terms of genomic alterations, according to a study published online July 18 in Nature.

Abstract
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Benefits of Prostate-Specific Antigen Testing Remain Unclear

THURSDAY, July 19 (HealthDay News) -- It remains unclear whether the benefits of prostate-specific antigen (PSA) testing outweigh the harms, but evidence suggests that men with a longer life expectancy may benefit from testing, according to a provisional clinical opinion from the American Society of Clinical Oncology published online July 16 in the Journal of Clinical Oncology.

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Poorer Patient Experience at Safety-Net Hospitals

THURSDAY, July 19 (HealthDay News) -- Safety-net hospitals (SNHs) perform worse on nearly every measure of patient experience, according to a study published online July 16 in the Archives of Internal Medicine.

Abstract
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ANCA-Associated Vasculitis Has Genetic Component

THURSDAY, July 19 (HealthDay News) -- A genome-wide association study of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis shows a genetic contribution to disease susceptibility, which differs between granulomatosis with polyangiitis and microscopic polyangiitis, according to a study published in the July 19 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Post-Pneumonectomy, New Lung Growth ID'd in Adult Patient

THURSDAY, July 19 (HealthDay News) -- New lung growth can occur in adult humans, according to a case report published in the July 19 issue of the New England Journal of Medicine.

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High Serum Ceramides Linked to Increased Alzheimer's Risk

THURSDAY, July 19 (HealthDay News) -- Older women with high levels of specific serum ceramides have an increased risk of developing Alzheimer's disease (AD), according to a study published online July 18 in Neurology.

Abstract
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Editorial (subscription or payment may be required)

HIV-2 Infection Inhibits HIV-1 Disease Progression

WEDNESDAY, July 18 (HealthDay News) -- HIV-1 disease progression seems to be inhibited by co-infection with HIV-2, with the slower rate of progression enhanced in those whose HIV-2 infection preceded HIV-1 infection, according to a study published in the July 19 issue of the New England Journal of Medicine.

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Milk Thistle Not Effective for Refractory Chronic Hepatitis C

WEDNESDAY, July 18 (HealthDay News) -- Use of the milk thistle extract silymarin does not provide additional benefit compared with placebo for patients with treatment-resistant chronic hepatitis C virus (HCV), according to a study published in the July 18 issue of the Journal of the American Medical Association.

Abstract
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Smoking Ups Recurrent Viral Hepatitis Post-Liver Transplant

WEDNESDAY, July 18 (HealthDay News) -- For liver transplant recipients, smoking correlates with an increased risk of recurrent viral hepatitis, according to a study published in the July issue of Liver Transplantation.

Abstract
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Social Network Analysis IDs Informal Physician Networks

TUESDAY, July 17 (HealthDay News) -- Informal networks among physicians who share patients demonstrate substantial geographic variability, while within networks, physician and patient characteristics are similar, according to a study published in the July 18 issue of the Journal of the American Medical Association.

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Gut Microbiota Correlate With Diet, Health in Elderly

TUESDAY, July 17 (HealthDay News) -- Analysis of gut microbiota from elderly individuals shows distinct groups that correlate with measures of health, including frailty and markers of inflammation, according to a study published online July 13 in Nature.

Abstract
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Sodium Accumulation Noted in Brain in Multiple Sclerosis

TUESDAY, July 17 (HealthDay News) -- Use of sodium 23 (23Na) magnetic resonance imaging (MRI) has identified dramatic increases in total sodium concentration (TSC) in the brain of patients with advanced relapsing-remitting multiple sclerosis (RR MS), with increased sodium in gray matter correlating with disability, according to a study published online July 17 in Radiology.

Abstract
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Free Light Chains Identified in Chronic Rhinosinusitis

MONDAY, July 16 (HealthDay News) -- Patients with chronic rhinosinusitis (CRS) have increased free light chain (FLC) concentrations, particularly those with CRS with nasal polyps (CRSwNP), according to a study published online July 5 in Allergy.

Abstract
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Dental Composite Affects Child Psychosocial Functioning

MONDAY, July 16 (HealthDay News) -- Children with greater exposure to bisphenol-A-glycidyl-methacrylate (bisGMA)-based dental composite exhibit impaired psychosocial functioning compared with children exposed to urethane dimethacrylate-based compomer, according to a study published online July 16 in Pediatrics.

Abstract
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Factors Influencing Hepatitis C RNA Levels in Drug Users ID'd

MONDAY, July 16 (HealthDay News) -- Levels of hepatitis C virus (HCV) RNA in injection drug users are independently associated with various demographic, viral, and host genetic factors, including being older, male, African-American, and co-infected with HIV, according to a study published in the July issue of Hepatology.

Abstract
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Vitamin D Deficiency Linked to Poorer Lung Function in Children

FRIDAY, July 13 (HealthDay News) -- For children with asthma treated with inhaled corticosteroids, vitamin D deficiency correlates with poorer lung function, compared to that of children with vitamin D sufficiency or insufficiency, according to a study published online July 12 in the American Journal of Respiratory and Critical Care Medicine.

Abstract
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Nebivolol Better Preserves Exercise Performance at Altitude

FRIDAY, July 13 (HealthDay News) -- Under high altitude (HA) hypoxemia conditions, exercise performance seems to be better preserved with nebivolol than carvedilol, according to a study published in the August issue of Cardiovascular Therapeutics.

Abstract
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Brain Tracer Indicates Risk of Future Cognitive Decline

FRIDAY, July 13 (HealthDay News) -- A radioactive tracer that can image amyloid-beta deposits in the brain can indicate whether older adults are at risk of cognitive decline and developing Alzheimer's disease, according to a study published online July 11 in Neurology.

Abstract
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High Phobic Anxiety Linked to Relative Telomere Length

FRIDAY, July 13 (HealthDay News) -- Older women who have phobic anxiety have shorter relative telomere lengths, according to a study published online July 11 in PLoS One.

Abstract
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CDC: Babesiosis Risk in Northeast/Upper Midwest Travel

THURSDAY, July 12 (HealthDay News) -- Adults and children are vulnerable to a host of tick- and mosquito-borne diseases in many Midwestern, Northeastern, and Southwestern states, according to two reports published in the July 13 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

Full Text - Babesiosis
Full Text - West Nile

Turmeric Component Reduces Type 2 Diabetes Incidence

THURSDAY, July 12 (HealthDay News) -- A component of turmeric -- curcumin -- reduces the incidence of type 2 diabetes and improves β-cell function in adults with prediabetes, according to a study published online July 6 in Diabetes Care.

Abstract
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Novel Immune Target Identified in Multiple Sclerosis

WEDNESDAY, July 11 (HealthDay News) -- About half of a subgroup of patients with multiple sclerosis have autoantibodies to a potassium channel in the brain, according to a study published in the July 12 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Pathophysiology May Help ID Rare, Early Form of Alzheimer's

WEDNESDAY, July 11 (HealthDay News) -- In dominantly inherited Alzheimer's disease, clinical and biomarker changes occur decades before the expected onset of disease symptoms, according to a study published online July 11 in the New England Journal of Medicine.

Abstract
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Trackable Blood Cells Feasible for MRI Monitoring

WEDNESDAY, July 11 (HealthDay News) -- Blood cells labeled with superparamagnetic particles of iron oxide (SPIO) are safe and can be tracked by magnetic resonance imaging (MRI), which may allow better monitoring of cell-based therapies, according to a study published online July 10 in Circulation: Cardiovascular Imaging.

Abstract
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'Mad Cow' Detectable Earlier in Autonomic Nervous System

WEDNESDAY, July 11 (HealthDay News) -- Prions responsible for bovine spongiform encephalopathy (BSE) are detectable in the autonomic nervous system before the central nervous system, according to a study published online July 11 in The American Journal of Pathology.

Abstract
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Flu Shot in Pregnancy Not Tied to Adverse Fetal Outcomes

TUESDAY, July 10 (HealthDay News) -- Exposure to adjuvanted influenza A(H1N1)pdm09 vaccination during pregnancy does not increase the risk of adverse fetal outcomes, and influenza vaccination correlates with a small but significantly increased risk of Guillain-Barré Syndrome (GBS), according to two studies published in the July 11 issue of the Journal of the American Medical Association.

Abstract - Pasternak
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Abstract - De Wals
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Sleep Deprivation Affects Immune Cell Rhythm

TUESDAY, July 10 (HealthDay News) -- Sleep deprivation affects the daily rhythms and levels of granulocytes, and mirrors the body's immune response to stress, according to a study published in the July 1 issue of SLEEP.

Abstract
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New Test Helps Evaluate Erbitux's Merit

MONDAY, July 9 (HealthDay News) -- A new genetic test to help doctors determine if the drug Erbitux would be an effective treatment for certain colorectal cancer patients has been approved by the U.S. Food and Drug Administration.

this approval

Sunburn Detection and Repair Mechanism Identified

MONDAY, July 9 (HealthDay News) -- Sunburned skin is detected through release of damaged RNA, which stimulates an inflammatory response from the surrounding cells, according to research published online July 8 in Nature Medicine.

Abstract
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Evidence of Herd Immunity After Introduction of HPV Vaccine

MONDAY, July 9 (HealthDay News) -- Following introduction of the human papillomavirus (HPV) vaccine there has been a significant decrease in the prevalence of vaccine-type HPV among vaccinated young women and evidence of herd protection in unvaccinated women, according to a study published online July 9 in Pediatrics.

Abstract
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Sentinel Node Biopsy Safe for Vulvar Squamous Cell Cancer

FRIDAY, July 6 (HealthDay News) -- For women with squamous cell carcinoma (SCC) of the vulva, sentinel lymph node (SLN) biopsy may be safely used in place of inguinal femoral lymphadenectomy, according to research published online July 2 in the Journal of Clinical Oncology.

Abstract
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Three SNPs Linked to Aortic Stenosis in Older Adults

FRIDAY, July 6 (HealthDay News) -- Three single nucleotide polymorphisms (SNPs) are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal of Cardiology.

Abstract
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Test Approved to Help Manage CMV in Transplant Patients

THURSDAY, July 5 (HealthDay News) -- The first DNA test to help doctors gauge the progress of antiviral treatment in solid organ transplant patients with cytomegalovirus (CMV) has been approved by the U.S. Food and Drug Administration.

solid organ transplant

CDC: Chagas Disease May Be Overlooked in Newborns

THURSDAY, July 5 (HealthDay News) -- Chagas disease, a parasitic infection that can lead to cardiomyopathy, is usually transmitted by contact with triatomine insects, but it can be passed congenitally, according to a case report published in the July 6 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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Poor Coverage, Not Ineffective Vaccine Averts Polio Abolition

THURSDAY, July 5 (HealthDay News) -- Bivalent and monovalent oral poliovirus vaccines (OPVs) are similarly effective, but decreases in vaccine coverage in parts of Pakistan and southern Afghanistan are hampering efforts to eradicate poliomyelitis, according to a study published online July 4 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Stem Cells From Skin Can Display Huntington's Characteristics

THURSDAY, July 5 (HealthDay News) -- Neural cells generated from skin cells from patients with Huntington's disease (HD), which is characterized by CAG repeat expansions, show characteristic features of the disease, including neurodegeneration, according to a study published online June 28 in Cell Stem Cell.

Abstract
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First Over-the-Counter HIV Test Approved

TUESDAY, July 3 (HealthDay News) -- The first over-the-counter test to detect antibodies to the virus that causes AIDS has been approved by the U.S. Food and Drug Administration, the agency said Tuesday.

AIDS.gov

Community, Hospital MRSA Bacteremia Down in U.S. Military

TUESDAY, July 3 (HealthDay News) -- The rates of both community-onset and hospital-onset methicillin-resistant Staphylococcus aureus (MRSA) bacteremia decreased from 2005 to 2010 among military personnel, according to a study published in the July 4 issue of the Journal of the American Medical Association.

Abstract
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No Increase in Shingles After Vaccine in Those on Biologics

TUESDAY, July 3 (HealthDay News) -- Live attenuated herpes zoster (HZ) vaccine is not associated with an increased risk of HZ shortly after vaccination in patients treated with biologics for immune-mediated diseases, according to a study published in the July 4 issue of the Journal of the American Medical Association.

Abstract
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Ovarian Grafts Restore Endocrine Function Long Term

TUESDAY, July 3 (HealthDay News) -- For female cancer survivors, heterotopic transplantation of cryobanked human ovarian tissue results in restoration of endocrine function within a few months that can last for as long as seven years, according to a study published in the June issue of the Journal of Assisted Reproduction and Genetics.

Abstract
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Rheumatoid Arthritis Drug Not Linked to Specific Birth Defects

TUESDAY, July 3 (HealthDay News) -- The rheumatoid arthritis drug leflunomide is not a major cause of birth defects in women who inadvertently become pregnant while taking the drug, although pregnancy should be avoided, according to a study in the July issue of Arthritis & Rheumatism.

Abstract
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Incretin Effect Independent of Glycemia Level

MONDAY, July 2 (HealthDay News) -- The enhanced insulin secretion after meals mediated by two intestinal hormones, known as the incretin effect, is independent of glycemia in healthy individuals, according to a study published online June 25 in Diabetes.

Abstract
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