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Category: Pharmacy | Monthly Briefing

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July 2012 Briefing - Pharmacy

Last Updated: August 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for July 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Higher Rates of Pertussis With Acellular Pertussis Vaccine

TUESDAY, July 31 (HealthDay News) -- Children who receive acellular pertussis vaccines have higher rates of pertussis compared with those receiving whole cell pertussis vaccines, according to a research letter published in the Aug. 1 issue of the Journal of the American Medical Association.

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Levels of Etonogestrel Lower in Obese Women After Implant

TUESDAY, July 31 (HealthDay News) -- Obese women who receive a contraceptive implant have lower drug levels in the six months following implant insertion compared with normal-weight women, according to a study published in the August issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Donepezil Found Helpful in Dementia With Lewy Bodies

TUESDAY, July 31 (HealthDay News) -- For patients with dementia with Lewy bodies (DLB), treatment with 5 or 10 mg/day donepezil is associated with significant cognitive, behavioral, and global function improvements, according to research published in the July issue of the Annals of Neurology.

Abstract
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Short/Long-Term Analyses Deem Etanercept Safe for Psoriasis

FRIDAY, July 27 (HealthDay News) -- Etanercept treatment is well tolerated for psoriasis, with no indication of dose-related or cumulative toxicity in short- or long-term analyses, according to a study published in the August issue of the Journal of the American Academy of Dermatology.

Abstract
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'Bath Salts' Demonstrate High Potential for Abuse

FRIDAY, July 27 (HealthDay News) -- Mephedrone, a synthetic stimulant known as "bath salts," stimulates reward centers in the brain in a similar manner to cocaine, indicating a high potential for abuse, according to a study published in the Sept. 1 issue of Behavioural Brain Research.

Abstract
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Rituximab Useful in Idiopathic Membranous Nephropathy

FRIDAY, July 27 (HealthDay News) -- For patients with idiopathic membranous nephropathy (IMN) and persistent nephrotic syndrome, rituximab treatment is associated with good rates of partial or complete remission with stabilized or improved renal function, according to a study published online July 19 in the Journal of the American Society of Nephrology.

Abstract
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Low-Dose Duloxetine Deemed Safe for Urinary Incontinence

FRIDAY, July 27 (HealthDay News) -- Duloxetine appears safe for the routine clinical care of women with stress urinary incontinence (SUI), according to a study published online July 23 in the British Journal of Clinical Pharmacology.

Abstract
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Excess Maternal Iodine Linked to Congenital Hypothyroidism

THURSDAY, July 26 (HealthDay News) -- Excess maternal iodine supplementation can result in congenital hypothyroidism, according to a study published online July 26 in The Journal of Pediatrics.

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Clopidogrel Response Remains Stable After Acute MI

THURSDAY, July 26 (HealthDay News) -- For patients with acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI), the rate of high on-treatment platelet reactivity (HTPR) despite clopidogrel therapy remains relatively stable for six months, according to a study published online in the August issue of The American Journal of Cardiology.

Abstract
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Selenium, Vitamins C, E May Lower Pancreatic Cancer Risk

THURSDAY, July 26 (HealthDay News) -- Higher intakes of the antioxidants selenium and vitamins C and E reduce the risk of pancreatic cancer by two-thirds, according to a study published online July 23 in Gut.

Abstract
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Immunosuppressant Switch Cuts Skin Cancer Post-Transplant

WEDNESDAY, July 25 (HealthDay News) -- In kidney-transplant patients with at least one cutaneous squamous-cell carcinoma, switching immunosuppressants (from calcineurin inhibitors to sirolimus) is associated with increased skin cancer-free survival and delayed development of new skin cancers, according to a study published in the July 26 issue of the New England Journal of Medicine.

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Vitamin E Intake Inversely Linked to Liver Cancer Risk

WEDNESDAY, July 25 (HealthDay News) -- Evidence suggests that vitamin E in the diet or from supplements may reduce the risk of developing liver cancer in men and women, according to research published online July 17 in the Journal of the National Cancer Institute.

Abstract
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Two-Thirds of Medicaid Patients Adherent to Chronic Meds

TUESDAY, July 24 (HealthDay News) -- Based on a Medicaid claims model, among New York City (NYC) Medicaid participants, adherence to chronic medications is inadequate, with considerable racial disparities noted, according to a study published online June 22 in the Journal of Urban Health.

Abstract
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Tudorza Pressair Approved for COPD

TUESDAY, July 24 (HealthDay News) -- The Tudorza Pressair (aclidinium bromide) inhaler has been approved by the U.S. Food and Drug Administration to treat narrowing of the lung airways associated with chronic obstructive pulmonary disease (COPD) in people 18 and older.

COPD

Researchers Find New Treatment Promising for Tuberculosis

TUESDAY, July 24 (HealthDay News) -- Based on early bactericidal activity (EBA) studies, PA-824-moxifloxacin-pyrazinamide may be suitable for development as an anti-tuberculosis agent, according to a study published online July 23 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Experts Advise Antiretrovirals for All HIV-Infected Patients

MONDAY, July 23 (HealthDay News) -- Based on recent data, current recommendations suggest that all patients infected with HIV should be treated with antiretroviral therapy (ART), according to research published in the July 25 issue of the Journal of the American Medical Association, a theme issue on HIV/AIDS, to coincide with the International AIDS Conference, held from July 22 to 27 in Washington, D.C.

Abstract
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More Information

HIV Drug-Resistance Up in Resource-Limited Settings

MONDAY, July 23 (HealthDay News) -- In resource-limited settings, the prevalence of HIV-1 drug resistance has increased since antiretroviral rollout, according to a study published online July 23 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Children Continue to Be Underrepresented in Drug Trials

MONDAY, July 23 (HealthDay News) -- Even for conditions with a high pediatric disease burden, only a small proportion of clinical drug trials study pediatric patients, according to research published online July 23 in Pediatrics.

Abstract
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Bortezomib Ups Response, Survival in Multiple Myeloma

MONDAY, July 23 (HealthDay News) -- For patients with newly diagnosed multiple myeloma (MM), induction treatment with a combination of bortezomib, doxorubicin, and dexamethasone (PAD) followed by bortezomib maintenance therapy improves complete response (CR), progression-free survival (PFS), and overall survival (OS) rates, according to a study published online July 16 in the Journal of Clinical Oncology.

Abstract
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Editorial

Hair Loss Drug Shows Long-Term Sexual Side Effects

MONDAY, July 23 (HealthDay News) -- For men with finasteride-associated side effects, sexual dysfunction may persist for months or years, even after discontinuation of the drug, according to a study published online July 12 in The Journal of Sexual Medicine.

Abstract
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Afinitor Approved for Advanced Breast Cancer

FRIDAY, July 20 (HealthDay News) -- Afinitor (everolimus) has been approved in combination with the drug exemestane to treat postmenopausal women with advanced hormone-receptor positive, HER2-negative breast cancer, the U.S. Food and Drug Administration said Friday.

breast cancer

Kyprolis Approved for Multiple Myeloma

FRIDAY, July 20 (HealthDay News) -- Kyprolis (carfilzomib) has been approved by the U.S. Food and Drug Administration to treat certain people with multiple myeloma who have already been given at least two prior therapies.

multiple myeloma

Heart Medication Converts Cancer Cells Into Vaccine

FRIDAY, July 20 (HealthDay News) -- A class of heart medications, cardiac glycosides, can induce immunogenic cell death (ICD), whereby dying cancer cells are converted into a vaccine that stimulates antitumor response, according to a study published in the July 18 issue of Science Translational Medicine.

Abstract
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Peri-Op Antidepressant Use Safe for Face-Lift Surgery

FRIDAY, July 20 (HealthDay News) -- For patients undergoing face-lift surgery, perioperative use of selective serotonin reuptake inhibitors (SSRIs) seems safe and does not adversely affect outcome, according to a study published in the July/August issue of the Archives of Facial Plastic Surgery.

Abstract
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Effect of Phosphate Binders in Chronic Kidney Disease Unclear

FRIDAY, July 20 (HealthDay News) -- Although phosphate binders lower serum and urinary phosphorus and reduce progression of secondary hyperthyroidism, they also promote progression of vascular calcification, and consequently their safety and efficacy for patients with chronic kidney disease (CKD) is unclear, according to a study published online July 19 in the Journal of the American Society of Nephrology.

Abstract
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Animal Study: Long-Term Ritalin Doesn't Impact Growth

FRIDAY, July 20 (HealthDay News) -- Chronic use of methylphenidate (Ritalin) in young monkeys has no significant effect on growth or the dopamine system, or the likelihood of becoming addicted to cocaine, according to a study published online July 18 in Neuropsychopharmacology.

Abstract
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BMI Affects Aromatase Inhibitor-Linked Estrogen Suppression

FRIDAY, July 20 (HealthDay News) -- Body mass index (BMI) affects the level of estradiol and estrone sulfate suppression achieved when treating postmenopausal women with estrogen receptor (ER)-positive breast cancer with either of two aromatase inhibitors, anastrozole or letrozole, according to a study published online July 16 in the Journal of Clinical Oncology.

Abstract
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Editorial

Poorer Patient Experience at Safety-Net Hospitals

THURSDAY, July 19 (HealthDay News) -- Safety-net hospitals (SNHs) perform worse on nearly every measure of patient experience, according to a study published online July 16 in the Archives of Internal Medicine.

Abstract
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Editorial

~12,000 Preventable Deaths in English Hospitals Annually

THURSDAY, July 19 (HealthDay News) -- Approximately 12,000 hospital deaths in England each year are preventable, according to research published online July 7 in BMJ Quality & Safety.

Abstract
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Milk Thistle Not Effective for Refractory Chronic Hepatitis C

WEDNESDAY, July 18 (HealthDay News) -- Use of the milk thistle extract silymarin does not provide additional benefit compared with placebo for patients with treatment-resistant chronic hepatitis C virus (HCV), according to a study published in the July 18 issue of the Journal of the American Medical Association.

Abstract
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Interferon Beta Doesn't Reduce Disability Progression in MS

WEDNESDAY, July 18 (HealthDay News) -- Interferon beta does not reduce the progression of disability in patients with relapsing-remitting multiple sclerosis (MS), according to a study published in the July 18 issue of the Journal of the American Medical Association.

Abstract
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Editorial

Social Network Analysis IDs Informal Physician Networks

TUESDAY, July 17 (HealthDay News) -- Informal networks among physicians who share patients demonstrate substantial geographic variability, while within networks, physician and patient characteristics are similar, according to a study published in the July 18 issue of the Journal of the American Medical Association.

Abstract
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Editorial

New Drug Approved for Colonoscopy Preparation

TUESDAY, July 17 (HealthDay News) -- Prepopik (sodium picosulfate, magnesium oxide, and citric acid) has been approved by the U.S. Food and Drug Administration for adults preparing for a colonoscopy, a diagnostic procedure to inspect the colon's inner lining.

National Digestive Diseases Information Clearinghouse

First Drug Approved to Lower Risk of Acquiring HIV

TUESDAY, July 17 (HealthDay News) -- Truvada (emtricitabine/tenofovir disoproxil fumarate) is the first drug to be approved by the U.S. Food and Drug Administration to reduce the risk of contracting HIV among adults at higher risk of acquiring the AIDS-causing virus.

AIDS.gov

Drotrecogin Alfa (Activated) Effective in Severe Sepsis

TUESDAY, July 17 (HealthDay News) -- For patients with severe sepsis, drotrecogin alfa (activated) is associated with significant reductions in hospital mortality, according to a study published online July 17 in The Lancet Infectious Diseases.

Abstract
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Editorial (subscription or payment may be required)

Induction Chemo Beneficial in Locally Advanced Pancreatic CA

TUESDAY, July 17 (HealthDay News) -- For most patients with locally advanced pancreatic carcinoma (LAPC), induction with a combination of gemcitabine and oxaliplatin (GEMOX) followed by chemoradiotherapy (CRT) is feasible, resulting in clinical benefit, a chance of resectability, and improved survival, according to a study published online July 6 in Cancer.

Abstract
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Aspirin Still First-Line Therapy for Unstable Angina/NSTEMI

MONDAY, July 16 (HealthDay News) -- Aspirin is still the first line of therapy for patients with unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and ticagrelor can be used in place of clopidogrel or prasugrel instead of aspirin or as a second antiplatelet agent, according to a report from the American College of Cardiology Foundation (ACCF)/American Heart Association (AHA) published online July 16 in Circulation.

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Vitamin D Deficiency Linked to Poorer Lung Function in Children

FRIDAY, July 13 (HealthDay News) -- For children with asthma treated with inhaled corticosteroids, vitamin D deficiency correlates with poorer lung function, compared to that of children with vitamin D sufficiency or insufficiency, according to a study published online July 12 in the American Journal of Respiratory and Critical Care Medicine.

Abstract
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Nebivolol Better Preserves Exercise Performance at Altitude

FRIDAY, July 13 (HealthDay News) -- Under high altitude (HA) hypoxemia conditions, exercise performance seems to be better preserved with nebivolol than carvedilol, according to a study published in the August issue of Cardiovascular Therapeutics.

Abstract
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Chemo Combo Promising for Pancreatic Neuroendocrine Tumors

FRIDAY, July 13 (HealthDay News) -- The combination of temozolomide and bevacizumab seems to benefit patients with advanced pancreatic neuroendocrine tumors (NETs), according to a study published online July 9 in the Journal of Clinical Oncology.

Abstract
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Abuse-Deterrent OxyContin Produces Unexpected Outcome

THURSDAY, July 12 (HealthDay News) -- Introduction of an abuse-deterrent formulation of OxyContin correlated with a significant reduction in its abuse, but was accompanied by an increase in abuse of other opioids and heroin, according to a letter published in the July 12 issue of the New England Journal of Medicine.

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Drug Reduces Graft-Versus-Host After Stem Cell Transplant

THURSDAY, July 12 (HealthDay News) -- The chemokine receptor CCR5 antagonist maraviroc, which blocks lymphocyte trafficking, is safe and reduces the incidence of acute graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem-cell transplantation, according to a phase I and II study published in the July 12 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)

HIV Preexposure Prophylaxis With Antiretrovirals Explored

WEDNESDAY, July 11 (HealthDay News) -- The efficacy of prophylactic treatment with the antiretroviral combination of tenofovir and emtricitabine (TDF-FTC) seems to vary in different populations, according to three studies published online July 11 in the New England Journal of Medicine.

Abstract - Baeten
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Abstract - Van Damme
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Abstract - Thigpen
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Editorial

Supplement Mixture Improves Memory in Mild Alzheimer's

WEDNESDAY, July 11 (HealthDay News) -- A supplement mixture (Souvenaid) containing dietary precursors and specific nutrients can improve memory in drug-naive patients with mild Alzheimer's disease (AD), according to a study published in the July issue of the Journal of Alzheimer's Disease.

Abstract
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Study Supports Chemo After Periampullary Cancer Surgery

TUESDAY, July 10 (HealthDay News) -- After adjusting for prognostic variables, patients who receive adjuvant chemotherapy following resection of periampullary adenocarcinomas have improved survival compared with those who receive only observation, according to a study published in the July 11 issue of the Journal of the American Medical Association.

Abstract
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Flu Shot in Pregnancy Not Tied to Adverse Fetal Outcomes

TUESDAY, July 10 (HealthDay News) -- Exposure to adjuvanted influenza A(H1N1)pdm09 vaccination during pregnancy does not increase the risk of adverse fetal outcomes, and influenza vaccination correlates with a small but significantly increased risk of Guillain-Barré Syndrome (GBS), according to two studies published in the July 11 issue of the Journal of the American Medical Association.

Abstract - Pasternak
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Abstract - De Wals
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Editorial

Acadesine Doesn't Improve Outcomes After CABG

TUESDAY, July 10 (HealthDay News) -- Administration of acadesine before, during, and immediately after coronary artery bypass graft (CABG) surgery to regulate adenosine does not reduce the composite measure of all-cause mortality, nonfatal stroke, or the need for mechanical support for severe left ventricular dysfunction (SLVD), according to a study published in the July 11 issue of the Journal of the American Medical Association.

Abstract
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Top Medical Organizations Support Hormone Replacement

MONDAY, July 9 (HealthDay News) -- Ten years after the Women's Health Initiative (WHI) declared that hormone replacement therapy may do more harm than good in the prevention of chronic disease, the North American Menopause Society (NAMS), the American Society for Reproductive Medicine, and The Endocrine Society have issued a joint statement concluding hormone therapy safe and effective in the treatment of menopausal symptoms.

More Information

Evidence of Herd Immunity After Introduction of HPV Vaccine

MONDAY, July 9 (HealthDay News) -- Following introduction of the human papillomavirus (HPV) vaccine there has been a significant decrease in the prevalence of vaccine-type HPV among vaccinated young women and evidence of herd protection in unvaccinated women, according to a study published online July 9 in Pediatrics.

Abstract
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Unsuccessful Fertility Drug Use Lowers Breast Cancer Risk

MONDAY, July 9 (HealthDay News) -- Women with unsuccessful use of fertility drugs are at a significantly reduced risk of young-onset breast cancer, according to a study published online July 6 in the Journal of the National Cancer Institute.

Abstract
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Editorial

Gestational Diabetes Risk Up With Antipsychotic Use

FRIDAY, July 6 (HealthDay News) -- Maternal use of antipsychotic drugs during pregnancy is linked to an increased risk of gestational diabetes, according to a study published in the July issue of the Archives of General Psychiatry.

Abstract
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Obesity Is a Risk Factor for Poor Remission Rates in RA

FRIDAY, July 6 (HealthDay News) -- For patients with long-standing rheumatoid arthritis treated with anti-tumor necrosis factor-α (anti-TNFα) therapies, obesity is related to poor remission rates, according to a study published online June 21 in Arthritis Care & Research.

Abstract
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Early Intensive Diabetes Therapy Preserves β-Cell Function

FRIDAY, July 6 (HealthDay News) -- Early, intensive therapy for type 2 diabetes with either insulin plus metformin or triple oral therapy preserves β-cell function for at least 3.5 years, according to a study published in the July issue of Diabetes Care.

Abstract
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Medicare Part D Gap Lowers Maintenance Antidepressant Use

FRIDAY, July 6 (HealthDay News) -- The Medicare Part D coverage gap correlates with modest reductions in the use of antidepressants among older adults, which are similar to the reduction in prescriptions for heart failure and diabetes medications, according to a study published in the July issue of the Archives of General Psychiatry.

Abstract
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One-Third of Opioid Overdose Deaths Involve Methadone

THURSDAY, July 5 (HealthDay News) -- Methadone is involved in more than 30 percent of opioid-related overdose deaths, with the overdose death rate significantly higher than for other opioid pain relievers, according to a report published in the July 3 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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Eltrombopag Linked to Clinical Response in Aplastic Anemia

THURSDAY, July 5 (HealthDay News) -- For some patients with severe refractory aplastic anemia, treatment with eltrombopag is associated with clinically significant improvements in platelet, erythroid, and neutrophil lineages at 12 weeks, according to a study published in the July 5 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

High-Dose Vitamin D 'Somewhat Favorable' in Fracture Prevention

THURSDAY, July 5 (HealthDay News) -- High-dose (≥800 IU daily) vitamin D supplementation is associated with a decreased risk of hip fracture and nonvertebral fractures among older adults, according to a study published in the July 5 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Dose-Escalated Cetuximab Tolerated in Colorectal Cancer

THURSDAY, July 5 (HealthDay News) -- For patients with irinotecan-refractory metastatic colorectal cancer (CRC), dose escalation of cetuximab is well tolerated and may improve response and disease control rates, but patients experience more grade ≥2 skin reactions, according to a study published online July 2 in the Journal of Clinical Oncology.

Abstract
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Editorial

Limited Evidence Links Pioglitazone to Bladder Cancer

TUESDAY, July 3 (HealthDay News) -- Limited evidence supports an increased risk of bladder cancer in adults with type 2 diabetes treated with thiazolidinediones, specifically pioglitazone, according to a review and meta-analysis published online July 3 in CMAJ, the journal of the Canadian Medical Association.

Abstract
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First Over-the-Counter HIV Test Approved

TUESDAY, July 3 (HealthDay News) -- The first over-the-counter test to detect antibodies to the virus that causes AIDS has been approved by the U.S. Food and Drug Administration, the agency said Tuesday.

AIDS.gov

Rheumatoid Arthritis Drug Not Linked to Specific Birth Defects

TUESDAY, July 3 (HealthDay News) -- The rheumatoid arthritis drug leflunomide is not a major cause of birth defects in women who inadvertently become pregnant while taking the drug, although pregnancy should be avoided, according to a study in the July issue of Arthritis & Rheumatism.

Abstract
Full Text (subscription or payment may be required)

Pharmacist Intervention Does Not Prevent Medication Errors

MONDAY, July 2 (HealthDay News) -- A pharmacist-delivered intervention does not significantly improve the rate of clinically important medication errors following discharge among hospitalized heart patients, according to a study published in the July 3 issue of the Annals of Internal Medicine.

Full Text (subscription or payment may be required)

Long-Term Rituximab Safe for Patients With Wegener's

MONDAY, July 2 (HealthDay News) -- Repeated and prolonged use of rituximab for B-cell depletion to treat relapses or maintain remission is safe and effective in patients with refractory granulomatosis with polyangiitis (GPA; Wegener's), a primary systemic small vessel vasculitis, according to a study published online June 21 in Arthritis & Rheumatism.

Abstract
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