Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Endocrinology | Family Medicine | Internal Medicine | Oncology | Pharmacy | Journal

Back to Journal Articles

Vandetanib Slows Progression of Advanced Thyroid Cancer

Last Updated: August 14, 2012.

 

Phase 2 study shows benefit for locally advanced or metastatic differentiated thyroid carcinomas

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
The tyrosine kinase inhibitor vandetanib is associated with longer progression-free survival compared with placebo for patients with locally advanced or metastatic differentiated thyroid carcinoma, according to a study published online Aug. 14 in The Lancet Oncology.

TUESDAY, Aug. 14 (HealthDay News) -- The tyrosine kinase inhibitor vandetanib is associated with longer progression-free survival (PFS) compared with placebo for patients with locally advanced or metastatic differentiated thyroid carcinoma, according to a study published online Aug. 14 in The Lancet Oncology.

Sophie Leboulleux, M.D., from the Université Paris-Sud in Villejuif, France, and colleagues examined the efficacy and safety of vandetanib in a double-blind, phase 2 trial involving adults (18 years or older) with locally advanced or metastatic differentiated thyroid cancer at 16 European medical centers. Patients were randomly allocated to receive vandetanib (72 patients) or matched placebo (73 patients).

The researchers found that, by data cut-off, 72 percent of patients in the vandetanib group and 84 percent in the placebo group had progressed, and 26 and 29 percent, respectively, had died. The median PFS was 11.1 months for patients in the vandetanib group and 5.9 months in the placebo group, with a significantly longer PFS for the vandetanib group (hazard ratio, 0.63). The most common grade 3 or worse adverse events that occurred more frequently in the vandetanib group versus the placebo group were QTc prolongation (14 percent versus none), diarrhea (10 percent versus none), asthenia (7 versus 4 percent), and fatigue (5 percent versus none). Death from treatment-related serious adverse events occurred for two patients in the vandetanib group and one in the placebo group.

"To the best of our knowledge, vandetanib is the first targeted agent to demonstrate improved PFS in patients with locally advanced or metastatic differentiated thyroid cancer in a randomized phase 2 study," the authors write. "Substantial prolongation of the time to disease progression would benefit these patients, but meaningful assessment of PFS needs a randomized phase 3 study."

Several authors disclosed financial ties to pharmaceutical companies, including AstraZeneca, which funded the study and manufactures vandetanib.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Poor Follow-Up of Hospital Tests Often Due to Late Orders Next: Novel System Improves Retinal Prostheses in Mouse Model

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.