Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Dermatology | Oncology | Pathology | Pharmacy | Journal

Back to Journal Articles

Metastatic Melanoma Responds to First-Line Interleukin-21

Last Updated: August 23, 2012.

 

Overall response rate of 22.5 percent, independent of BRAF mutation, IL-21 receptor expression

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
In the first-line treatment of metastatic melanoma, interleukin-21 shows an overall response rate of 22.5 percent and warrants further study, according to research published online Aug. 20 in the Journal of Clinical Oncology.

THURSDAY, Aug. 23 (HealthDay News) -- In the first-line treatment of metastatic melanoma, interleukin-21 (IL-21) shows an overall response rate (ORR) of 22.5 percent and warrants further study, according to research published online Aug. 20 in the Journal of Clinical Oncology.

Teresa M. Petrella, M.D., of the Sunnybrook Odette Cancer Centre in Toronto, and colleagues conducted a phase 2, multicenter study to evaluate the efficacy and safety of IL-21 in patients with metastatic melanoma. Two of the groups received either 30 µg/kg per day (30 patients) or 50 µg/kg per day (three patients) by intravenous bolus for five days of each week during weeks one, three, and five of an eight-week cycle. A third group received 50 µg/kg per day (seven patients) for five days of each week during weeks one and three of a six-week cycle.

The researchers found that treatment-related adverse events included fatigue, rash, diarrhea, nausea, and myalgia. The ORR was 22.5 percent, with nine partial responses and 16 with stable disease. Median duration of response for all responders was 5.3 months. Response was not dependent on either BRAF mutation status or IL-21 receptor expression. Overall, median progression-free survival was 4.3 months and median overall survival was 12.4 months.

"Promising antitumor activity was observed at both doses and schedules used in this trial, although the numbers treated are too small for definitive comparisons to be made," the authors write. "Responses were seen at all disease sites, including skin, lymph nodes, lung, liver, and other visceral organs."

Two study authors disclosed receiving research funding from ZymoGenetics.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Tattoo Ink Found to Be Source of M. Chelonae Outbreak Next: Racial Disparity ID'd in Health Behaviors of Fifth-Graders

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.