Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Gastroenterology | Oncology | Surgery | Journal

Back to Journal Articles

Pre-Op Eltrombopag Reduces Need for Platelet Transfusions

Last Updated: August 23, 2012.

 

Oral thrombopoietin-receptor agonist effective, but increased portal-vein thrombosis halts trial

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
For patients with chronic liver disease who require an invasive procedure as part of their routine care, the oral thrombopoietin-receptor agonist eltrombopag reduces the need for platelet transfusions, but also results in an increased incidence of portal-vein thrombosis, according to a study published in the Aug. 23 issue of the New England Journal of Medicine.

THURSDAY, Aug. 23 (HealthDay News) -- For patients with chronic liver disease who require an invasive procedure as part of their routine care, the oral thrombopoietin-receptor agonist eltrombopag reduces the need for platelet transfusions, but also results in an increased incidence of portal-vein thrombosis, according to a study published in the Aug. 23 issue of the New England Journal of Medicine.

Nezam H. Afdhal, M.D., from the Beth Israel Deaconess Medical Center in Boston, and colleagues randomly assigned 292 patients with chronic liver disease and platelet counts of less than 50,000 per cubic millimeter to receive either eltrombopag (75 mg daily) or placebo for 14 days before a planned elective invasive procedure, performed within five days of receiving the last dose.

The researchers found that platelet transfusion (before, during, and up to seven days after surgery) was avoided in 104 of 145 patients who received eltrombopag and in 28 of 147 who received placebo (72 versus 19 percent; P < 0.001). There were no significant differences in bleeding episodes of World Health Organization grade 2 or higher, which were reported in 17 percent of the eltrombopag group and 23 percent of the placebo group. Six patients receiving eltrombopag had thrombotic events of the portal venous system, compared with one patient who received placebo, which triggered early termination of the study. Other adverse events were similar in incidence and severity between the groups.

"Eltrombopag reduced the need for platelet transfusions in patients with chronic liver disease who were undergoing elective invasive procedures, but it was associated with an increased incidence of portal-vein thrombosis, as compared with placebo," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including GlaxoSmithKline, which funded the study and manufactures eltrombopag.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Racial Disparity ID'd in Health Behaviors of Fifth-Graders Next: Chronic Cerebrospinal Venous Insufficiency Not Specific to MS

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.