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Category: Endocrinology | Monthly Briefing

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August 2012 Briefing - Diabetes & Endocrinology

Last Updated: September 04, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for August 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Study Quantifies Effect of TV Viewing on Adolescent BMI

FRIDAY, Aug. 31 (HealthDay News) -- For adolescents, a decrease in television (TV) viewing time correlates with a lower body mass index (BMI) z score, according to a study published in the September/October issue of the Journal of Nutrition Education and Behavior.

Abstract
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Fructose and Sugar Substitutes Alter Gut Microbiota

FRIDAY, Aug. 31 (HealthDay News) -- High consumption of fructose, artificial sweeteners, and sugar alcohols affect host-gastrointestinal microbe interactions and may contribute to the development of metabolic disorders and obesity, according to research published in the September issue of Obesity Reviews.

Abstract
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HbA1c ≥6.5 Percent Is Specific, Not Sensitive for T1DM

FRIDAY, Aug. 31 (HealthDay News) -- Using a glycated hemoglobin (HbA1c) threshold of ≥6.5 percent is a specific but not sensitive early indicator of type 1 diabetes (T1D) in high-risk children and young adults, according to a study published in the September issue of Diabetes Care.

Abstract
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Even Normal Range Albuminuria Ups Cardiovascular Risk

FRIDAY, Aug. 31 (HealthDay News) -- For patients with type 2 diabetes with normal albumin levels, any degree of albuminuria is associated with an increased risk of cardiovascular events, according to a study published online Aug. 30 in the Journal of the American Society of Nephrology.

Abstract
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Effective Short-, Long-Term Weight-Loss Strategies Differ

FRIDAY, Aug. 31 (HealthDay News) -- In postmenopausal women, some weight-loss strategies that are successful for the short-term are not effective or sustainable for long-term weight loss, according to a study published in the September issue of the Journal of the Academy of Nutrition and Dietetics.

Abstract
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Lung Cancer Risk Unaffected by Metformin Use in Diabetes

THURSDAY, Aug. 30 (HealthDay News) -- Patients with type 2 diabetes who take metformin do not have a reduced risk of lung cancer, in contrast to previous observational studies, according to a study published online Aug. 24 in Diabetes Care.

Abstract
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Sleep Apnea Tied to Insulin Resistance in Young, Lean Men

TUESDAY, Aug. 28 (HealthDay News) -- In healthy, lean, young men, the presence of obstructive sleep apnea (OSA) correlates with insulin resistance and compensatory hyperinsulinemia to maintain normal glucose levels, according to a study published online Aug. 21 in Diabetes Care.

Abstract
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Myeloperoxidase Marker of Inflammation in Obese Children

MONDAY, Aug. 27 (HealthDay News) -- In obese prepubertal children, myeloperoxidase (MPO) is an early biomarker of inflammation and cardiovascular disease risk, according to a study published online Aug. 21 in Diabetes Care.

Abstract
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Poor Survival for Obese Women With HR+ Breast Cancer

MONDAY, Aug. 27 (HealthDay News) -- Women with hormone receptor-positive operable breast cancer have reduced survival if they are obese, according to a study published online Aug. 27 in Cancer.

Abstract
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In Type 2 DM, Proteinuria With SBP <130 Ups CVD Mortality

FRIDAY, Aug. 24 (HealthDay News) -- Patients with type 2 diabetes, proteinuria, and systolic blood pressure (BP) <130 mm Hg are at an increased risk of total and cardiovascular disease (CVD) mortality, suggesting that proteinuria should be taken into account when establishing target systolic BP levels for prevention of fatal CVD events, according to research published online Aug. 14 in the Journal of Internal Medicine.

Abstract
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Muscle-Related Statin Effects Seem to Correlate With Potency

FRIDAY, Aug. 24 (HealthDay News) -- The rates of muscle-related adverse effects (AEs) differ greatly for various statins, with the highest reported rates seen for rosuvastatin, according to research published online Aug. 22 in PLoS One.

Abstract
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In Diabetes, Gastric Emptying Remains Stable Over Time

FRIDAY, Aug. 24 (HealthDay News) -- Gastric emptying of solids and liquids and gastrointestinal symptoms remain stable over time in patients with long-term type 1 and type 2 diabetes, according to a study published online Aug. 13 in Diabetes Care.

Abstract
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Deep Brain Stimulation Could Treat Obesity

FRIDAY, Aug. 24 (HealthDay News) -- Deep brain stimulation that targets the reward centers of the brain rather than only feeding behaviors could be effective in treating obesity, according to a review published in the August issue of Neurosurgery.

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Experimental Combo Treatment Worsens Type 1 Diabetes

THURSDAY, Aug. 23 (HealthDay News) -- A treatment regimen that is effective in preventing diabetes in a mouse model of the disease leads to worsening disease in patients with type 1 diabetes, according to a study published online June 20 in Diabetes.

Abstract
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Reporting of Dietary Intake Methods in Obesity Trials Poor

THURSDAY, Aug. 23 (HealthDay News) -- More care needs to be taken in reporting dietary intake methods in childhood and adolescent obesity intervention trials in order to be able to better evaluate and replicate study methods, according to the results of a systematic review published online Aug. 15 in Obesity Reviews.

Abstract
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Childhood Radiation Exposure of Pancreas Linked to Diabetes

THURSDAY, Aug. 23 (HealthDay News) -- There is a dose-response relationship between childhood radiation exposure of the pancreas and subsequent risk of diabetes, according to a study published online Aug. 23 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Modifiable Risk Factors Key in Social Inequality of Diabetes

THURSDAY, Aug. 23 (HealthDay News) -- Modifiable risk factors, particularly health behaviors and body mass index (BMI), measured repeatedly over time, account for about half of the socioeconomic differential observed in type 2 diabetes, according to a study published online Aug. 21 in BMJ.

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Bariatric Surgery Cuts Incidence of Type 2 Diabetes in Obese

WEDNESDAY, Aug. 22 (HealthDay News) -- Bariatric surgery is very effective in reducing the long-term incidence of type 2 diabetes in obese individuals, according to a study published in the Aug. 23 issue of the New England Journal of Medicine.

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Infant Exposure to Antibiotics Linked to Later Obesity

WEDNESDAY, Aug. 22 (HealthDay News) -- Infants exposed to antibiotics at younger than 6 months of age are at higher risk of being overweight in childhood, according to a study published online Aug. 21 in the International Journal of Obesity.

Abstract
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Low HDL Cholesterol Ups Risk of Diabetic Nephropathy

WEDNESDAY, Aug. 22 (HealthDay News) -- High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for the development of diabetic nephropathy, but not retinopathy, in patients with type 2 diabetes, according to research published online Aug. 13 in Diabetes Care.

Abstract
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Drug-Eluting Stents Lead to Fewer Adverse Cardiac Events

TUESDAY, Aug. 21 (HealthDay News) -- Among ST-segment elevation myocardial infarction (STEMI) patients, the use of biolimus-eluting stents with biodegradable polymer results in a lower rate of major adverse cardiac events, compared with patients with bare-metal stents, at one year following primary percutaneous coronary intervention (PCI), according to a study published in the Aug. 22/29 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Novel Risk Markers Improve Prediction of Heart Disease

TUESDAY, Aug. 21 (HealthDay News) -- The addition of certain novel risk markers can improve risk prediction for incident coronary heart disease (CHD) or cardiovascular disease (CVD) above that of the Framingham Risk Score (FRS) in intermediate-risk individuals; while the addition of the carotid intima-media thickness (CIMT) offers limited improvement in risk prediction for first-time myocardial infarction or stroke, above that of the FRS, according to two studies published in the Aug. 22/29 issue of the Journal of the American Medical Association.

Abstract - Yeboah
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Abstract - Den Ruijter
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Evidence-Based Public Health Interventions Identified

TUESDAY, Aug. 21 (HealthDay News) -- Evidence-based public health interventions to improve dietary habits, increase physical activity, and reduce tobacco use are identified in an American Heart Association scientific statement published online Aug. 20 in Circulation.

Abstract
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Study Identifies Sleep Apnea in 50 Percent of Women

TUESDAY, Aug. 21 (HealthDay News) -- Half of adult women aged 20 to 70 years may have obstructive sleep apnea, which correlates with age, obesity, and hypertension, according to a study published online Aug. 16 in the European Respiratory Journal.

Abstract
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BMI, Post-Exercise Knee Laxity Change Tied to OA Progression

TUESDAY, Aug. 21 (HealthDay News) -- In patients with osteoarthritis (OA) of the knee, changes in knee joint laxity during stair climbing or other repetitive physical activity and baseline body mass index (BMI) are associated with disease progression, according to a study published online Aug. 8 in Arthritis & Rheumatism.

Abstract
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Family Hx of Early Death Ups Risk of Early Cardiac Disease

TUESDAY, Aug. 21 (HealthDay News) -- The risk of early cardiovascular disease in patients younger than 50 years of age is significantly and consistently increased for those with a family history of premature cardiovascular death, according to a study published in the Aug. 28 issue of the Journal of the American College of Cardiology.

Abstract
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2012 Indicators of Well-Being for Older Americans Issued

MONDAY, Aug. 20 (HealthDay News) -- The estimates of selected indicators for well-being for older Americans for 2012 have been released by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Obesity Plus Metabolic Factors Speeds Up Cognitive Decline

MONDAY, Aug. 20 (HealthDay News) -- For individuals who are metabolically abnormal, increasing body mass index (BMI) correlates with faster cognitive decline, according to a study published in the Aug. 21 issue of Neurology.

Abstract
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Yo-Yo Dieters Still Benefit From Weight Loss Efforts

MONDAY, Aug. 20 (HealthDay News) -- Yo-yo dieting does not negatively affect participation in lifestyle intervention or the benefits of diet and exercise, according to a study published online Aug. 14 in Metabolism -- Clinical and Experimental.

Abstract
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Soy Linked to Exacerbated Congenital Hypothyroidism

MONDAY, Aug. 20 (HealthDay News) -- Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 in Pediatrics.

Abstract
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Urinary BPA Increased in Severe Coronary Artery Disease

FRIDAY, Aug. 17 (HealthDay News) -- Bisphenol A (BPA) exposure, as measured by urinary BPA (uBPA) concentrations, is higher in individuals with severe coronary artery disease (CAD) compared to those with no vessel disease, according to a study published online Aug. 15 in PLoS One.

Abstract
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Even Minor Changes in Physical Activity Improve Bone Health

FRIDAY, Aug. 17 (HealthDay News) -- For premenopausal women, physical activity correlates with decreased sclerostin, increased serum insulin-like growth factor-I (s-IGF-I), and increased bone formation markers, according to a study published online Aug. 3 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Delayed Gratification at Age 4 Predictive of BMI in Adulthood

FRIDAY, Aug. 17 (HealthDay News) -- Delayed gratification among preschoolers can predict body mass index (BMI) about 30 years later, according to a study published online Aug. 16 in The Journal of Pediatrics.

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Olive Oil Consumption Linked to Increased Serum Osteocalcin

THURSDAY, Aug. 16 (HealthDay News) -- Consumption of olive oil in addition to a Mediterranean diet correlates with increased osteocalcin levels and improvements in bone formation markers in elderly men at high cardiovascular risk, according to a study published online Aug. 1 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Post-Intracerebral Bleed, BP Control Poorer for Blacks

THURSDAY, Aug. 16 (HealthDay News) -- Blood pressure (BP) control is poor at 30 days and one year after intracerebral hemorrhage (ICH), particularly among black patients, according to a study published online Aug. 16 in Stroke.

Abstract
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Exenatide Has Hemodynamic Effects in Healthy Men

THURSDAY, Aug. 16 (HealthDay News) -- The glucagon-like peptide-1 agonist, exenatide, used in the treatment of type 2 diabetes mellitus, has significant acute hemodynamic effects on healthy volunteers, according to a study published in the September issue of the British Journal of Clinical Pharmacology.

Abstract
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Computer-Based Obesity Tx Programs Show Promise

THURSDAY, Aug. 16 (HealthDay News) -- Interactive computer-based weight loss and weight maintenance interventions are more effective than no or minimal interventions, but are less effective than in-person treatment, according to a systematic review published online Aug. 15 in The Cochrane Library.

Abstract
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Ten New Susceptibility Loci Identified for Type 2 Diabetes

THURSDAY, Aug. 16 (HealthDay News) -- Using a new DNA chip, the Metabochip, which includes 196,725 variants, to identify nominal associations for type 2 diabetes (T2D) and other metabolic and cardiovascular traits, 10 novel loci have been identified for T2D, according to research published online Aug. 12 in Nature Genetics.

Abstract
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Guidelines Updated for Thyroid Disease in Pregnancy

THURSDAY, Aug. 16 (HealthDay News) -- A task force of The Endocrine Society has reviewed the evidence and updated guidelines for the management of thyroid dysfunction during pregnancy and the postpartum period, according to an article published in the Aug. 1 issue of the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Clinical Practice Guideline

ABO Blood Group Correlated With Coronary Heart Disease

WEDNESDAY, Aug. 15 (HealthDay News) -- There is a significantly elevated risk of incident coronary heart disease (CHD) among individuals with blood group A, B, or AB compared with those with blood group O, according to a study published online Aug. 14 in Arteriosclerosis, Thrombosis, and Vascular Biology.

Abstract
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Long-Term Type 2 Diabetes Ups Pancreatic Cancer Mortality

WEDNESDAY, Aug. 15 (HealthDay News) -- Among patients with pancreatic adenocarcinoma (PAC), those with pre-existing type 2 diabetes mellitus (T2DM) for longer than five years have an increased mortality risk, according to a study published online Aug. 1 in Cancer.

Abstract
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Cocoa Flavanols May Improve Cognitive Function in Elderly

TUESDAY, Aug. 14 (HealthDay News) -- Regular consumption of cocoa flavanols may be associated with improved cognitive functioning in elderly patients with mild cognitive impairment, according to a study published online Aug. 13 in Hypertension.

Abstract
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Poor Follow-Up of Hospital Tests Often Due to Late Orders

TUESDAY, Aug. 14 (HealthDay News) -- Poor follow-up of test results at or after discharge from the hospital is often due to tests requested on the day of discharge, according to a letter to the editor published online Aug. 13 in the Archives of Internal Medicine.

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Vandetanib Slows Progression of Advanced Thyroid Cancer

TUESDAY, Aug. 14 (HealthDay News) -- The tyrosine kinase inhibitor vandetanib is associated with longer progression-free survival (PFS) compared with placebo for patients with locally advanced or metastatic differentiated thyroid carcinoma, according to a study published online Aug. 14 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Regular Exercise in Middle Age Lowers Inflammatory Markers

MONDAY, Aug. 13 (HealthDay News) -- Middle-aged adults who have regularly engaged in physical activity for more than a decade appear to benefit from lower markers of inflammation, according to a study published online Aug. 13 in Circulation.

Abstract
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Competitive Food Laws Tied to Less BMI Change in Teens

MONDAY, Aug. 13 (HealthDay News) -- Exposure to strong state competitive food laws, which regulate the nutrition content of foods and drinks sold outside of federal school meal programs, during childhood is associated with lower body mass index (BMI) change, according to a study published online Aug. 13 in Pediatrics.

Abstract
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Prevalence, Risk of Thyroid Disease Up in Vitiligo Patients

MONDAY, Aug. 13 (HealthDay News) -- Both the prevalence and the risk of thyroid diseases are significantly higher among patients with vitiligo compared to those without the condition, according to a study published online Aug. 3 in the British Journal of Dermatology.

Abstract
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Cataract Risk Up for Statin Users With Type 2 Diabetes

MONDAY, Aug. 13 (HealthDay News) -- Statin use, which is substantially higher in patients with type 2 diabetes, correlates with an increased risk of age-related (AR) cataracts, according to a study published in the August issue of Optometry and Vision Science.

Abstract
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Urinary Proteomics Aids Early ID of Diabetic Nephropathy

MONDAY, Aug. 13 (HealthDay News) -- A biomarker classifier in urine can allow early detection of progression to diabetic nephropathy years before onset of macroalbuminuria, according to a study published online Aug. 7 in Diabetes.

Abstract
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Lucentis Approved for Diabetic Macular Edema

FRIDAY, Aug. 10 (HealthDay News) -- Lucentis (ranibizumab injection) has been approved by the U.S. Food and Drug Administration to treat diabetic macular edema (DME), an eye condition that can threaten the sight of those with diabetes, the agency said Friday in a news release.

diabetic eye disease

Phone Intervention Cost-Effective for Glycemic Control

FRIDAY, Aug. 10 (HealthDay News) -- The incremental per capita costs of a telephone-based intervention that moderately improves glycemic control in adults with type 2 diabetes are modest, according to a study published online July 30 in Diabetes Care.

Abstract
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Self-Perceived Overweight in Teens Impacts Weight Gain

FRIDAY, Aug. 10 (HealthDay News) -- Self-perceived overweight in normal-weight adolescents correlates with increased weight gain in early adulthood, according to a study published in the August issue of the Journal of Obesity.

Abstract
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Statin Benefits Outweigh Risk of Developing Diabetes

FRIDAY, Aug. 10 (HealthDay News) -- Statins increase the risk of developing diabetes, but only in individuals already at risk of the disease, and the benefits of statins in the prevention of cardiovascular disease and death outweigh the risks, according to a study published in the Aug. 11 issue of The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Life Expectancy Has Improved With Childhood Type 1 Diabetes

FRIDAY, Aug. 10 (HealthDay News) -- For children diagnosed with type 1 diabetes, life expectancy has increased, with about a 15-year improvement seen from a 1950-1964 subcohort to a 1965-1980 subcohort, according to a study published online July 30 in Diabetes.

Abstract
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Psyllium Reduces Metabolic Syndrome Risk Factors

THURSDAY, Aug. 9 (HealthDay News) -- Consumption of the fiber supplement psyllium correlates with reductions in risk factors for metabolic syndrome, according to a study published online Aug. 5 in Obesity Reviews.

Abstract
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CDC: Increase in Prevalence of Walking in the United States

THURSDAY, Aug. 9 (HealthDay News) -- The prevalence of walking (defined as walking for leisure or transportation in at least one bout of 10 minutes or more in the last week) increased in the United States from 2005 to 2010, with an increased likelihood of meeting the aerobic physical activity guideline noted for walkers, according to a study published in the Aug. 7 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly.

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Vaccine Transiently Modifies Autoimmunity in Diabetes

THURSDAY, Aug. 9 (HealthDay News) -- A tuberculosis vaccine can reduce autoimmunity and increase insulin production in patients with long-term type 1 diabetes, according to a study published online Aug. 8 in PLoS One.

Abstract
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After Bariatric Op, Controlled Diet Can Aid CaOx Supersaturation

THURSDAY, Aug. 9 (HealthDay News) -- After bariatric surgery, following a diet that is normal in calcium, low in oxalate, and moderate in protein, can improve urinary calcium oxalate (CaOx) supersaturation, but not urinary oxalate excretion, in patients with a history of kidney stones, according to a study published in the August issue of Urology.

Abstract
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Caloric Restriction Restores Glucose Response in Diabetes

THURSDAY, Aug. 9 (HealthDay News) -- Neuronal responsiveness of the hypothalamus to glucose, critical in the regulation of feeding, can be restored in patients with type 2 diabetes by short-term caloric restriction, according to a study published online July 30 in Diabetes.

Abstract
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Bariatric Surgery Cuts MI Incidence in Obese With T2DM

WEDNESDAY, Aug. 8 (HealthDay News) -- For obese individuals with type 2 diabetes, bariatric surgery reduces the incidence of some cardiovascular events, specifically myocardial infarction, according to a study published online Aug. 1 in Diabetes Care.

Abstract
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Growth Hormone-Releasing Hormone Ups Cognition in Elderly

WEDNESDAY, Aug. 8 (HealthDay News) -- Growth hormone-releasing hormone (GHRH) improves cognition in healthy older adults and those with mild cognitive impairment (MCI), according to a study published online Aug. 6 in the Archives of Neurology.

Abstract
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Mortality Up for Normal-Weight Adults With Incident Diabetes

TUESDAY, Aug. 7 (HealthDay News) -- Normal-weight adults who are diagnosed with new-onset diabetes have an increased mortality risk, compared with overweight/obese adults, according to a study published in the Aug. 8 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Weight Training Lowers Risk of Type 2 Diabetes in U.S. Men

TUESDAY, Aug. 7 (HealthDay News) -- Weight training or aerobic exercise independently lowers the risk of type 2 diabetes mellitus (T2DM); and for those with diabetes, physical activity (PA) correlates with a lower mortality risk, according to two studies published online Aug. 6 in the Archives of Internal Medicine.

Abstract - Grøntved
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Abstract - Sluik
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Skin Intrinsic Fluorescence Tied to Coronary Artery Disease

TUESDAY, Aug. 7 (HealthDay News) -- Skin intrinsic fluorescence (SIF) is significantly associated with coronary artery disease (CAD) in middle-aged adults with a long duration of type 1 diabetes, according to a study published online July 30 in Diabetes Care.

Abstract
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Donor Obesity Ups Risk of Poor Pediatric Transplant Outcome

TUESDAY, Aug. 7 (HealthDay News) -- Severe obesity, but not overweight, in adult donors is a risk factor for graft loss and mortality in pediatric liver transplant recipients, according to a study published in the August issue of Liver Transplantation.

Abstract
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Drug Helps Control Glucose in Congenital Hyperinsulinism

TUESDAY, Aug. 7 (HealthDay News) -- An experimental drug may be able to control blood glucose levels in patients with a form of congenital hyperinsulinism, according to a study published online Aug. 1 in Diabetes.

Abstract
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Clinicians Can Unintentionally Prompt Nocebo Effect

THURSDAY, Aug. 2 (HealthDay News) -- The nocebo effect, or induction of a symptom perceived as negative by sham treatment and/or the suggestion of negative expectation, may arise from suggestions by doctors and nurses, according to a study published in Deutsches Ärzteblatt International.

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Low Vitamin D, Frailty Impact Mortality Risk in Elderly

THURSDAY, Aug. 2 (HealthDay News) -- Adults over the age of 60 years with low vitamin D levels are more likely to be frail, and the combined effect of low vitamin D levels and frailty significantly increases the risk of mortality, according to a study published online June 13 in the European Journal of Clinical Nutrition.

Abstract
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Nutrition Type Affects Endocrinology in SGA Infants

WEDNESDAY, Aug. 1 (HealthDay News) -- Small-for-gestational-age (SGA) infants who are formula-fed (FOF) have elevated endocrine levels of high-molecular-weight (HMW) adiponectin and insulin growth factor-I (IGF-I) compared with breastfed (BRF) SGA infants, according to research published in the August issue of Diabetes.

Abstract
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Brain Connectivity Altered in Type 2 Diabetes

WEDNESDAY, Aug. 1 (HealthDay News) -- Patients with type 2 diabetes mellitus (T2DM) have reduced functional connectivity in the default mode network, which is associated with insulin resistance in some brain regions, according to a study published online July 26 in Diabetes.

Abstract
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