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Category: Oncology | Monthly Briefing

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August 2012 Briefing - Hematology & Oncology

Last Updated: September 04, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for August 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Advanced-Stage Cancer Patients Often Reluctant to Exercise

FRIDAY, Aug. 31 (HealthDay News) -- For individuals with advanced cancer, reluctance to participate in exercise may be due to symptoms, lack of specific guidance, and lack of recognition of the role of exercise in mitigating symptoms, according to a study published in the July issue of the Journal of Pain and Symptom Management.

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New Drug Approved for Chemo-Related Severe Neutropenia

FRIDAY, Aug. 31 (HealthDay News) -- The U.S. Food and Drug Administration has approved the drug tbo-filgrastim to treat certain cancer patients undergoing chemotherapy who have severe neutropenia, the FDA said in a news release.

Lung Cancer Risk Unaffected by Metformin Use in Diabetes

THURSDAY, Aug. 30 (HealthDay News) -- Patients with type 2 diabetes who take metformin do not have a reduced risk of lung cancer, in contrast to previous observational studies, according to a study published online Aug. 24 in Diabetes Care.

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Lower Prostate Cancer-Specific Death With Anticoagulant Use

THURSDAY, Aug. 30 (HealthDay News) -- Anticoagulant (AC) therapy, particularly aspirin, is associated with a reduced risk of prostate cancer-specific mortality (PCSM) among men treated with radical prostatectomy (RP) or radiotherapy (RT), according to a study published online Aug. 27 in the Journal of Clinical Oncology.

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Particular Donor Genotype Lowers Leukemia Relapse Rate

WEDNESDAY, Aug. 29 (HealthDay News) -- Patients with acute myeloid leukemia who receive a stem cell transplant from a donor with activating killer-cell immunoglobulin-like receptor (KIR) genotype KIR2DS1, which has ligand specificity for human leukocyte antigen (HLA)-C2 antigen, have a lower rate of relapse, according to a study published in the Aug. 30 issue of the New England Journal of Medicine.

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Mutation ID'd in Waldenström's Macroglobulinemia

WEDNESDAY, Aug. 29 (HealthDay News) -- MYD88 L265P is a common, recurring mutation in patients with Waldenström's macroglobulinemia, according to a study published in the Aug. 30 issue of the New England Journal of Medicine.

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Cetuximab, Paclitaxel Combo Active in Urothelial Cancer

WEDNESDAY, Aug. 29 (HealthDay News) -- The monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

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Gene Score IDs Prognosis in Metastatic Neuroblastoma

WEDNESDAY, Aug. 29 (HealthDay News) -- For children with metastatic MYCN-nonamplified neuroblastoma (NBL-NA) diagnosed at age 18 months or older, increased expression of tumor-associated inflammatory genes seems to correlate with poor prognosis, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

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Novel Agent Tolerable, Active for Advanced Colorectal Cancer

TUESDAY, Aug. 28 (HealthDay News) -- For patients with previously treated metastatic colorectal cancer who are refractory or intolerant to standard therapies, treatment with a novel oral nucleoside antitumor agent, TAS-102, is tolerable and shows promising efficacy, according to a phase 2 study published online Aug. 28 in The Lancet Oncology.

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Low-Frequency Gene Variant Linked to Brain Tumors

TUESDAY, Aug. 28 (HealthDay News) -- A low-frequency gene variant, rs55705857, is strongly associated with the risk of developing gliomas, with the strongest association seen in the presence of mutations in IDH1 and IDH2, according to a letter to the editor published online Aug. 26 in Nature Genetics.

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Regular Aspirin Use Doesn't Reduce Breast Cancer Risk

TUESDAY, Aug. 28 (HealthDay News) -- Regular use of aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), or acetaminophen does not appear to affect the risk of breast cancer overall or by specific subtypes in postmenopausal women, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

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For Patients With Prior MI, Vorapaxar Cuts Cardiac Events

MONDAY, Aug. 27 (HealthDay News) -- When added to standard antiplatelet treatment, including aspirin, the protease-activated receptor 1 inhibitor vorapaxar reduces the risk of a primary end point of cardiovascular (CV) death, myocardial infarction (MI), or stroke, for patients with a history of MI, according to a study published online Aug. 26 in The Lancet to coincide with presentation at the annual European Society of Cardiology Congress, held from Aug. 25 to 29 in Munich.

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Improved Survival for Prostate Cancer Seen in Post-PSA Era

MONDAY, Aug. 27 (HealthDay News) -- Overall survival for metastatic prostate cancer is significantly improved in a post-prostate-specific antigen (PSA) era trial compared with two trials conducted before the PSA era, according to research published online Aug. 23 in The Journal of Urology.

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Poor Survival for Obese Women With HR+ Breast Cancer

MONDAY, Aug. 27 (HealthDay News) -- Women with hormone receptor-positive operable breast cancer have reduced survival if they are obese, according to a study published online Aug. 27 in Cancer.

Abstract
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Stress Causes Lower INR in VTE Patients Not on Blood Thinners

FRIDAY, Aug. 24 (HealthDay News) -- The effect of psychological distress on clotting times and clotting factors varies in patients with venous thromboembolism (VTE) and depends on whether or not they are receiving oral anticoagulant (OAC) therapy, according to a Swiss study published in the August issue of the Journal of Thrombosis and Haemostasis.

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Outcomes Similar With Partial, Whole Breast Irradiation

FRIDAY, Aug. 24 (HealthDay News) -- Accelerated partial breast irradiation (APBI) yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation (WBI), with excellent three-year survival for women who develop an ipsilateral breast tumor recurrence (IBTR), according to a study published in the Sept. 1 issue of Cancer.

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RNA Assays Up Sensitivity of Urothelial Carcinoma Detection

TUESDAY, Aug. 21 (HealthDay News) -- Cxbladder, a derivative of the RNA assay uRNA, may be an effective alternative to cytology and nuclear matrix protein 22 (NMP22) assays for the detection of urothelial carcinoma, according to a study published in the September issue of The Journal of Urology.

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Childhood Radiation Exposure of Pancreas Linked to Diabetes

THURSDAY, Aug. 23 (HealthDay News) -- There is a dose-response relationship between childhood radiation exposure of the pancreas and subsequent risk of diabetes, according to a study published online Aug. 23 in The Lancet Oncology.

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Metastatic Melanoma Responds to First-Line Interleukin-21

THURSDAY, Aug. 23 (HealthDay News) -- In the first-line treatment of metastatic melanoma, interleukin-21 (IL-21) shows an overall response rate (ORR) of 22.5 percent and warrants further study, according to research published online Aug. 20 in the Journal of Clinical Oncology.

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Pre-Op Eltrombopag Reduces Need for Platelet Transfusions

THURSDAY, Aug. 23 (HealthDay News) -- For patients with chronic liver disease who require an invasive procedure as part of their routine care, the oral thrombopoietin-receptor agonist eltrombopag reduces the need for platelet transfusions, but also results in an increased incidence of portal-vein thrombosis, according to a study published in the Aug. 23 issue of the New England Journal of Medicine.

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Process Areas for Improvement ID'd in Early Prostate Cancer

WEDNESDAY, Aug. 22 (HealthDay News) -- For men with early prostate cancer undergoing expectant management, compliance with RAND structural indicators is high, but there is considerable variability in compliance with process indicators, according to a study published in the September issue of The Journal of Urology.

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Prolonged Dexamethasone Cuts Delayed Nausea After Chemo

WEDNESDAY, Aug. 22 (HealthDay News) -- Adding dexamethasone to prochlorperazine on days two and three, following palonosetron and dexamethasone on day one, reduces delayed nausea (DN) in patients receiving chemotherapy containing a platinum-based drug or an anthracycline, according to research published online Aug. 20 in the Journal of Clinical Oncology.

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Model Accurately Predicts Risk of Oral Cancer Progression

TUESDAY, Aug. 21 (HealthDay News) -- A model that incorporates loss of heterozygosity data can accurately predict which patients with low-grade oral cancer are likely to progress to higher grades, according to a study published online Aug. 21 in Cancer Prevention Research.

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High Density on Mammograms Not Tied to Risk of Death

TUESDAY, Aug. 21 (HealthDay News) -- High mammographic breast density is not associated with an increased risk of breast cancer-related or all-cause mortality, according to a study published online Aug. 21 in the Journal of the National Cancer Institute.

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Evidence-Based Public Health Interventions Identified

TUESDAY, Aug. 21 (HealthDay News) -- Evidence-based public health interventions to improve dietary habits, increase physical activity, and reduce tobacco use are identified in an American Heart Association scientific statement published online Aug. 20 in Circulation.

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Factors Tied to Photoprotection ID'd for Organ Recipients

TUESDAY, Aug. 21 (HealthDay News) -- For organ transplant recipients, patients factors, including sex and skin type, and receipt of advice from health care providers, are both associated with sun protective behaviors, according to a study published online Aug. 9 in the British Journal of Dermatology.

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No Benefit Seen for Adjuvant Oxaliplatin in Stage II Colon CA

TUESDAY, Aug. 21 (HealthDay News) -- For elderly patients with colon cancer or those with stage II disease, the addition of oxaliplatin to fluorouracil with leucovorin (FL) does not seem to offer any survival benefit, according to a study published online Aug. 20 in the Journal of Clinical Oncology.

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Post-Polyp Detection, CRC Risk ID'd by Colonoscopy Factors

MONDAY, Aug. 20 (HealthDay News) -- In the community setting, after colonoscopic polyp detection, colonoscopy-related factors such as incomplete polyp removal and lack of surveillance colonoscopies are more important than polyp characteristics in predicting subsequent colorectal cancer (CRC) risk, according to a study published in the Aug. 21 issue of the Annals of Internal Medicine.

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2012 Indicators of Well-Being for Older Americans Issued

MONDAY, Aug. 20 (HealthDay News) -- The estimates of selected indicators for well-being for older Americans for 2012 have been released by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Pathologists Tend to Reclassify Prior Nonmalignant Diagnoses

FRIDAY, Aug. 17 (HealthDay News) -- For dermatopathologists there is a trend toward reclassification of prior nonmalignant diagnoses of severely atypical dysplastic nevi as malignant, according to a study published in the September issue of the Journal of the American Academy of Dermatology.

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Study Finds Tobacco Use High in Developing Countries

FRIDAY, Aug. 17 (HealthDay News) -- Despite global tobacco control efforts, in low- and middle-income countries, nearly half of men use tobacco, women are starting to smoke at earlier ages, and quit ratios are low, according to a study published in the Aug. 18 issue of The Lancet, a theme issue on respiratory medicine.

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Chemo for Breast Cancer Acceptable During Pregnancy

THURSDAY, Aug. 16 (HealthDay News) -- For women diagnosed with early breast cancer during pregnancy, chemotherapy seems acceptable for both mother and infant, with most adverse effects relating to premature birth, according to a study published online Aug. 16 in The Lancet Oncology.

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Enzalutamide Prolongs Survival in Resistant Prostate Cancer

THURSDAY, Aug. 16 (HealthDay News) -- Men with metastatic castration-resistant prostate cancer after chemotherapy have improved survival and secondary end points after treatment with enzalutamide versus placebo, according to a study published online Aug. 15 in the New England Journal of Medicine.

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Benefit of PSA Reduced by Loss of Quality-Adjusted Life-Years

WEDNESDAY, Aug. 15 (HealthDay News) -- Although the European Randomized Study of Screening for Prostate Cancer (ERSPC) has reported a 29 percent reduction in prostate-cancer mortality for men who undergo prostate-specific antigen (PSA) screening, the benefit is attenuated by loss of quality-adjusted life-years (QALYs) due to post-diagnosis effects, according to a study published in the Aug. 16 issue of the New England Journal of Medicine.

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Long-Term Type 2 Diabetes Ups Pancreatic Cancer Mortality

WEDNESDAY, Aug. 15 (HealthDay News) -- Among patients with pancreatic adenocarcinoma (PAC), those with pre-existing type 2 diabetes mellitus (T2DM) for longer than five years have an increased mortality risk, according to a study published online Aug. 1 in Cancer.

Abstract
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Acquired Ovarian Cancer Drug Resistance Linked to Genomes

WEDNESDAY, Aug. 15 (HealthDay News) -- The genomes of tumors from patients with high-grade serous ovarian cancer display spatial and temporal genomic variation, with a greater degree of variation as tumors become resistant to chemotherapy, and resistance is associated with lower levels of the lipid transporter LRP1B, according to a study published in the Aug. 15 issue of Cancer Research.

Abstract
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Biomarker Found to Predict Therapy Benefit in Renal Cancer

WEDNESDAY, Aug. 15 (HealthDay News) -- Pretreatment serum lactate dehydrogenase (LDH) is a predictive biomarker for the survival benefit derived from treatment with the TORC1 inhibitor temsirolimus in patients with renal cell carcinoma (RCC), according to a study published online Aug. 13 in the Journal of Clinical Oncology.

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ABO Blood Group Correlated With Coronary Heart Disease

WEDNESDAY, Aug. 15 (HealthDay News) -- There is a significantly elevated risk of incident coronary heart disease (CHD) among individuals with blood group A, B, or AB compared with those with blood group O, according to a study published online Aug. 14 in Arteriosclerosis, Thrombosis, and Vascular Biology.

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Post-Meltdown, Psychological Distress Up Among Workers

TUESDAY, Aug. 14 (HealthDay News) -- The March 11, 2011, earthquake and tsunami that struck Japan, triggering the subsequent meltdown of nuclear reactors at the Fukushima Daiichi nuclear power plant, correlated with an increase in the levels of psychological distress of power plant workers; but, six months to one year later, radiation exposure among individuals in a neighboring community was low, according to two letters to the editor published in the Aug. 15 issue of the Journal of the American Medical Association.

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Denosumab Better for Breast Cancer With Bone Metastases

TUESDAY, Aug. 14 (HealthDay News) -- In women with advanced breast cancer and bone metastases, denosumab is better than zoledronic acid in preventing skeletal complications and improving health-related quality of life, according to a study published online Aug. 14 in Clinical Cancer Research.

Abstract
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Tissue Platinum Concentrations Linked to Response in NSCLC

TUESDAY, Aug. 14 (HealthDay News) -- For patients with non-small-cell lung cancer (NSCLC) who undergo neoadjuvant platinum-based chemotherapy, tissue platinum concentrations correlate positively with improved outcome, according to a study published online Aug. 13 in the Journal of Clinical Oncology.

Abstract
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Rat Study Shows Chrysotile Asbestos Is Strong Carcinogen

TUESDAY, Aug. 14 (HealthDay News) -- Chrysotile, a commercially used type of asbestos, induces malignant mesothelioma (MM) in the rat peritoneal cavity, with pathogenesis strongly linked to iron overload, according to a study published online Aug. 2 in The Journal of Pathology.

Abstract
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Vandetanib Slows Progression of Advanced Thyroid Cancer

TUESDAY, Aug. 14 (HealthDay News) -- The tyrosine kinase inhibitor vandetanib is associated with longer progression-free survival (PFS) compared with placebo for patients with locally advanced or metastatic differentiated thyroid carcinoma, according to a study published online Aug. 14 in The Lancet Oncology.

Abstract
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Poor Follow-Up of Hospital Tests Often Due to Late Orders

TUESDAY, Aug. 14 (HealthDay News) -- Poor follow-up of test results at or after discharge from the hospital is often due to tests requested on the day of discharge, according to a letter to the editor published online Aug. 13 in the Archives of Internal Medicine.

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Supplement Doses Inadequate for Androgen Deprivation Therapy

MONDAY, Aug. 13 (HealthDay News) -- Currently recommended calcium and vitamin D supplementation doses are inadequate to prevent bone mineral density (BMD) loss in men undergoing androgen deprivation therapy (ADT) for prostate cancer, according to a study published online July 25 in The Oncologist.

Abstract
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High-Risk HPV Present in Subset of Penile Carcinomas

MONDAY, Aug. 13 (HealthDay News) -- High-risk human papillomavirus (hrHPV) infection is found in a subset of penile squamous cell carcinomas (PSCCs) that may develop from undifferentiated penile intraepithelial neoplasia (PeIN), according to a study published online Aug. 6 in the Journal of the American Academy of Dermatology.

Abstract
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Aspirin Use Again Linked to Slightly Lower Cancer Mortality

MONDAY, Aug. 13 (HealthDay News) -- Daily aspirin use is associated with lower overall cancer mortality, but the association may be smaller than previously reported, according to a study published online Aug. 10 in the Journal of the National Cancer Institute.

Abstract
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Editorial

Radiation Prevents Mastectomy Post-Conservative Op in Elderly

MONDAY, Aug. 13 (HealthDay News) -- Following conservative surgery (CS), receipt of radiation therapy (RT) is associated with a decreased likelihood of subsequent mastectomy for most women aged 70 to 79 years with early breast cancer, according to a study published online Aug. 13 in Cancer.

Abstract
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Risk of Residual Disease Up in Triple Negative Breast Cancer

FRIDAY, Aug. 10 (HealthDay News) -- Women with triple negative (TN) breast cancer have a significantly increased risk of residual carcinoma after lumpectomy, according to a study published in the Aug. 15 issue of Cancer.

Abstract
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PSA Change After 5α Reductase Therapy Aids Cancer Diagnosis

FRIDAY, Aug. 10 (HealthDay News) -- The magnitude of change in serum prostate specific antigen (PSA) after 5α-reductase inhibitor therapy may help diagnose prostate cancer in men with persistently increased serum PSA and previously negative biopsies, according to a study published in the September issue of The Journal of Urology.

Abstract
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Prognostic Factors Identified in Mucoepidermoid Carcinoma

FRIDAY, Aug. 10 (HealthDay News) -- Diagnosis of low- or intermediate-grade tumors is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma (MEC) of the salivary glands, while advanced disease stage and perineural invasion are the most significant indicators of poor prognosis, according to a study published in the Aug. 15 issue of Cancer.

Abstract
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Marqibo Approved for Ph- Acute Lymphoblastic Leukemia

THURSDAY, Aug. 9 (HealthDay News) -- Marqibo (vincristine sulfate liposome injection) has been approved by the U.S. Food and Drug Administration to treat adults with Philadelphia chromosome negative acute lymphoblastic leukemia (ALL).

this approval

High IgE Levels Inversely Associated With Risk of Glioma

THURSDAY, Aug. 9 (HealthDay News) -- There appears to be an inverse relationship between elevated allergy biomarker levels (immunoglobulin E [IgE]) and the risk of developing glioma, which is detectable many years before tumor diagnosis, according to a study published online Aug. 1 in the Journal of the National Cancer Institute.

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Study Links Age, Insurance, but Not Race, to Chemo Rates

THURSDAY, Aug. 9 (HealthDay News) -- For women with breast cancer, disease characteristics correlate significantly with chemotherapy receipt, with no indication of racial barriers to treatment, according to a study published online Aug. 6 in the Journal of Clinical Oncology.

Abstract
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Editorial

Subcutaneous, IV Trastuzumab Comparable for Breast Cancer

THURSDAY, Aug. 9 (HealthDay News) -- For human epidermal growth factor receptor 2 (HER2)-positive early breast cancer, a subcutaneous formulation of trastuzumab is non-inferior to the standard intravenous formulation, according to a study published online Aug. 9 in The Lancet Oncology.

Abstract
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R-CHOP Benefits Older Mantle-Cell Lymphoma Patients

WEDNESDAY, Aug. 8 (HealthDay News) -- In older patients with mantle-cell lymphoma, a rituximab-based chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone [R-CHOP]) followed by maintenance therapy with rituximab improves survival, according to a study published in the Aug. 9 issue of the New England Journal of Medicine.

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Nonoperative Approach Feasible in Advanced Colon Cancer

WEDNESDAY, Aug. 8 (HealthDay News) -- Treating patients with surgically unresectable metastatic colon cancer and an asymptomatic intact primary tumor with bevacizumab and infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) chemotherapy is a viable and safe option, according to research published online Aug. 6 in the Journal of Clinical Oncology.

Abstract
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Editorial

Bortezomib Beneficial in Graft-Versus-Host Disease Prophylaxis

WEDNESDAY, Aug. 8 (HealthDay News) -- Patients with hematologic malignancies undergoing an HLA-mismatched unrelated donor (MMUD) reduced-intensity conditioning (RIC) hematopoietic stem cell transplantation (HSCT) may benefit from a prophylactic, short-course, bortezomib-based regimen to reduce the incidence of graft-versus-host disease (GVHD), according to research published online Aug. 6 in the Journal of Clinical Oncology.

Abstract
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Editorial

Cellular Protein Important in Breast Cancer Metastasis

TUESDAY, Aug. 7 (HealthDay News) -- A protein important in cell adhesion and migration is important in breast cancer metastasis, and its expression level predicts recurrence-free and distant metastasis-free survival, according to a study published online Aug. 7 in Cancer Research.

Abstract
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Limitations ID'd in Women's Breast Health in Pakistan

TUESDAY, Aug. 7 (HealthDay News) -- Women in Pakistan need more awareness about breast health and access to early detection, and there is marked inconsistency among general practitioners (GPs) with respect to screening practices, work-up, and management, according to a study published in the August issue of the Journal of the American College of Radiology.

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New Method Improves BRCA1/2 Mutation Detection

TUESDAY, Aug. 7 (HealthDay News) -- A next-generation sequencing method is a more effective method for identifying mutations in BRCA1 and BRCA2 genes, according to a study published online Aug. 5 in The Journal of Molecular Diagnostics.

Abstract
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Photosensitizing Antihypertensive Meds Up Risk of Lip Cancer

TUESDAY, Aug. 7 (HealthDay News) -- For non-Hispanic whites, long-term treatment with photosensitizing antihypertensive agents correlates with an increased likelihood of lip cancer, according to a study published online Aug. 6 in the Archives of Internal Medicine.

Abstract
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Superficial X-Ray Viable for Basal, Squamous Cell Carcinoma

MONDAY, Aug. 6 (HealthDay News) -- Superficial X-ray therapy remains a viable treatment for primary basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in select patients, according to a study published online July 23 in the Journal of the American Academy of Dermatology.

Abstract
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Unsuspected PE Does Not Up Mortality Risk in Cancer Patients

MONDAY, Aug. 6 (HealthDay News) -- Cancer patients with an unsuspected pulmonary embolism (UPE) do not have an increased mortality risk and have a similar risk of recurrent venous thromboembolism (VTE) to those with clinically suspected pulmonary embolism (PE), according to research published online July 27 in the Journal of Thrombosis and Haemostasis.

Abstract
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Zaltrap Approved for Advanced Colorectal Cancer

FRIDAY, Aug. 3 (HealthDay News) -- Zaltrap (ziv-aflibercept) has been approved by the U.S. Food and Drug Administration in combination with a FOLFIRI regimen for adults with advanced metastatic colorectal cancer, the agency said Friday.

National Cancer Institute

Gene Subnetworks Predict Risk of Leukemia Progression

FRIDAY, Aug. 3 (HealthDay News) -- Subnetworks of interacting genes can predict the risk of disease progression requiring treatment in patients with chronic lymphocytic leukemia, according to a study published online July 26 in Blood.

Abstract
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Depression May Affect Survival in Metastatic Renal Cancer

FRIDAY, Aug. 3 (HealthDay News) -- For patients with metastatic renal cell carcinoma (RCC), depressive symptoms may be a predictor of survival, with potential links to cortisol dysregulation and expression of pro-inflammatory and pro-metastatic genes, according to a study published online Aug. 1 in PLoS One.

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Clinicians Can Unintentionally Prompt Nocebo Effect

THURSDAY, Aug. 2 (HealthDay News) -- The nocebo effect, or induction of a symptom perceived as negative by sham treatment and/or the suggestion of negative expectation, may arise from suggestions by doctors and nurses, according to a study published in Deutsches Ärzteblatt International.

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Drug Combo Ups Survival in Metastatic Breast Cancer

WEDNESDAY, Aug. 1 (HealthDay News) -- The combination of anastrozole and fulvestrant improves survival in patients with hormone receptor-positive metastatic breast cancer, according to a study published in the Aug. 2 issue of the New England Journal of Medicine.

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RB Pathway Linked to Breast Cancer Treatment Response

THURSDAY, Aug. 2 (HealthDay News) -- Disruption of the retinoblastoma tumor suppressor (RB) pathway in breast cancer is associated with an improved response to neoadjuvant chemotherapy, according to a study published online July 18 in Clinical Cancer Research.

Abstract
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High-Cost Imaging of Advanced Cancer Patients Increasing

THURSDAY, Aug. 2 (HealthDay News) -- Use of imaging in stage IV cancer patients increased from 1995 to 2006, according to a study published online July 31 in the Journal of the National Cancer Institute.

Abstract
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Taxane-Induced Neuropathy Not Tied to Breast Cancer Outcome

THURSDAY, Aug. 2 (HealthDay News) -- For patients with operable breast cancer, peripheral neuropathy due to adjuvant taxane therapy does not correlate with improved outcomes, according to research published online July 30 in the Journal of Clinical Oncology.

Abstract
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Editorial

Men With Prostate Cancer Increasingly Don't Die From It

WEDNESDAY, Aug. 1 (HealthDay News) -- Men diagnosed with prostate cancer are more likely to die from other conditions, including heart disease, than from prostate cancer, according to a study published online July 25 in the Journal of the National Cancer Institute.

Abstract
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Cancer 'Stem Cells' Identified in Different Tumors

WEDNESDAY, Aug. 1 (HealthDay News) -- A small population of cancer cells seem able to propagate cancer cell growth, in solid tumors and in intestinal adenomas, according to two studies published online Aug. 1 in Nature and a third study also published online Aug. 1 in Science.

Abstract - Chen
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Abstract - Driessens
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Abstract - Schepers
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Psychological Distress Linked to Increased Mortality

WEDNESDAY, Aug. 1 (HealthDay News) -- There is a dose-response association for psychological distress and the risk of several causes of mortality, with increased mortality seen even at lower levels of distress, according to a meta-analysis published July 31 in BMJ.

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Active Surveillance Up in Multidisciplinary Prostate CA Care

WEDNESDAY, Aug. 1 (HealthDay News) -- Men with low-risk prostate cancer are more likely to pursue active surveillance when seen at a multidisciplinary prostate cancer clinic rather than when they see individual specialists in sequential settings, according to a study published online July 30 in the Journal of Clinical Oncology.

Abstract
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Adding Radiation Aids Pediatric Nonmetastatic Medulloblastoma

WEDNESDAY, Aug. 1 (HealthDay News) -- Compared with postoperative chemotherapy alone, adding conformal radiation therapy (CRT) to induction chemotherapy for the treatment of young children with nonmetastatic medulloblastoma increases event-free survival (EFS), according to a study published online July 30 in the Journal of Clinical Oncology.

Abstract
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