Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Cardiology | Family Medicine | Internal Medicine | Critical Care | Pathology | Journal

Back to Journal Articles

Remodeling Starts Within 48 Hours of Cardiac Injury

Last Updated: September 06, 2012.

 

Cardiac hypertrophy observed within two days of transverse aortic constriction in mice

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
After cardiac injury, signs of remodeling are observed as early as 48 hours, and include structural changes and enlargement of the heart, and associated changes in cell populations, according to a study published online Sept. 4 in The American Journal of Pathology.

THURSDAY, Sept. 6 (HealthDay News) -- After cardiac injury, signs of remodeling are observed as early as 48 hours, and include structural changes and enlargement of the heart, and associated changes in cell populations, according to a study published online Sept. 4 in The American Journal of Pathology.

Noting that most studies of cardiac hypertrophy examine changes a week after cardiac injury, Colby A. Souders, from Texas A&M Health Science Center in Temple, and colleagues examined the morphological and physiological changes in early cardiac remodeling in response to transverse aortic constriction in mice.

The researchers observed cardiac hypertrophy after 48 hours, with an enlarged left ventricular free wall and septum, an increase in heart weight, and an increase in wall thickness. There was also decreased capillary density after 48 hours, which was associated with increased levels of pericytes (connective tissue cells in small blood vessels) and returned to control levels by day seven. At day seven, cardiac hypertrophy peaked, with increased collagen deposition that was associated with increased levels of fibroblasts. Proteins involved in angiogenesis, extracellular matrix, and cell growth were concurrently expressed.

"Our data demonstrate that morphological changes in response to cardiovascular injury occur rapidly, and the present findings allow correlation of specific events that facilitate these changes," Souders and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Less Pain After Hysterectomy With Vessel Sealing Next: Congenital Disease Linked to Adipocyte Development

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.