Create Account | Sign In: Author or Forum

News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
Category: Family Medicine | Gastroenterology | Infections | Nursing | Pathology | Pediatrics | Pharmacy | Journal

Back to Journal Articles

Childhood Antibiotic Exposure Linked to Development of IBD

Last Updated: September 24, 2012.


Earlier exposure during childhood tied to even greater risk of inflammatory bowel disease

Share |

Comments: (0)



Early exposure to antianaerobic antibiotics in childhood is associated with an increased risk of developing inflammatory bowel disease, according to research published online Sept. 24 in Pediatrics.

MONDAY, Sept. 24 (HealthDay News) -- Early exposure to antianaerobic antibiotics in childhood is associated with an increased risk of developing inflammatory bowel disease (IBD), according to research published online Sept. 24 in Pediatrics.

Matthew P. Kronman, M.D., from the University of Washington in Seattle, and colleagues retrospectively analyzed data from 464 U.K. ambulatory practices participating in The Health Improvement Network. Children followed for at least two years during the period of 1994 to 2009 were monitored between practice enrollment and IBD development, practice deregistration, 19 years of age, or death. Patients with previous IBD were excluded.

The researchers found that, of the 1,072,426 subjects, 748 developed IBD. The incidence rates of IBD were 0.83 per 10,000 person-years for unexposed children and 1.52 for exposed children, correlating with an 84 percent increase in the relative risk. While exposure throughout childhood was associated with developing IBD, this relationship decreased with increasing age at exposure (adjusted hazard ratios: 5.51 for exposure before the age of 1 year; 2.62 for age 5; and 1.57 for age 15). Each antibiotic course correlated with a 6 percent increase in the IBD hazard. There was a dose-response effect noted, with receipt of more than two antibiotic courses more strongly linked to IBD development compared with receipt of one to two courses, with adjusted hazard ratios of 4.77 versus 3.33.

"Exposure to antianaerobic antibiotics during childhood was associated with development of the lifelong autoimmune condition IBD," the authors write. "Our study suggests that reduction in childhood antianaerobic antibiotic use may have the potential to help curb the rising incidence of childhood IBD."

Several authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Previous: AAP Strongly Discourages Home Trampolines Next: Taste Perceptions Differ for Obese, Non-Obese Children

Reader comments on this article are listed below. Review our comments policy.

Submit your opinion:





Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application


 advertisement.gif (61x7 -- 0 bytes)



Useful Sites
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2015
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.