BPA Alters Oogenesis and Follicle Formation in PrimatesLast Updated: September 25, 2012. Rhesus monkeys exposed to bisphenol A experience alterations in early oogenesis and follicle formation, according to a study published online Sept. 24 in the Proceedings of the National Academy of Sciences.
TUESDAY, Sept. 25 (HealthDay News) -- Rhesus monkeys exposed to bisphenol A (BPA) experience alterations in early oogenesis and follicle formation, according to a study published online Sept. 24 in the Proceedings of the National Academy of Sciences.
Noting that low-dose exposure to BPA adversely affects oogenesis in rodents, Patricia A. Hunt, Ph.D., from Washington State University in Pullman, and colleagues investigated whether BPA induces similar disturbances in the developing primate ovary. Two different exposure protocols were implemented: single oral doses and continuous exposure via subdermal implant.
The researchers found that, in second trimester fetuses, BPA exposure at the time of meiotic onset induced subtle disturbances in prophase events. Third trimester fetuses exposed to single oral doses during the time of follicle formation exhibited an increase in multioocyte follicles. These findings were similar to those reported in rodents. Persistent unenclosed oocytes in the medullary region and small, non-growing oocytes in secondary and antral follicles were new phenotypes evident in continuously exposed animals.
"Because effects on both stages of oogenesis were elicited using doses that yield circulating levels of BPA analogous to those reported in humans, these findings raise concerns for human reproductive health," Hunt and colleagues conclude.