Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Endocrinology | Internal Medicine | Nephrology | Pharmacy | Journal

Back to Journal Articles

Novel Liver X Receptor Agonist Benefits Diabetic Nephropathy

Last Updated: October 22, 2012.

 

Synthetic agonist suppresses expression of osteopontin, improves nephropathy in mice

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
A new therapeutic target that activates the liver X receptor suppresses expression of inflammatory genes, including osteopontin, and improves kidney health and function in a mouse model of diabetes, according to a study published online Oct. 18 in the Journal of the American Society of Nephrology.

MONDAY, Oct. 22 (HealthDay News) -- A new therapeutic target that activates the liver X receptor (LXR) suppresses expression of inflammatory genes, including osteopontin, and improves kidney health and function in a mouse model of diabetes, according to a study published online Oct. 18 in the Journal of the American Society of Nephrology.

To assess the effects of activation of LXR in diabetic nephropathy, Hiromi Tachibana, from Okayama University in Japan, and colleagues administered the synthetic LXR agonist T0901317 to mice with streptozotocin-induced diabetes.

The researchers found that administration of the LXR agonist correlated with a decrease in urinary albumin excretion, without altering blood glucose levels. The LXR agonist also attenuated macrophage infiltration, mesangial matrix accumulation, and interstitial fibrosis. Activation of LXR correlated with inhibition of gene expression of osteopontin and other inflammatory mediators in the kidney cortex. In vitro experiments showed that LXR activation inhibited AP-1-dependent transcriptional activation of the osteopontin promoter, thereby suppressing osteopontin expression in proximal tubular epithelial cells.

"Because osteopontin is a key component in the inflammatory response and recruitment of monocytes/macrophages into the diabetic kidney, inhibition of osteopontin expression by LXR agonists could be a therapeutic target in human diabetic nephropathy," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: House Dust Protein Worsens Allergic Asthma Next: Metabolic Factors Impact Risk of Death From Prostate Cancer

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.