Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Endocrinology | Pathology | Journal

Back to Journal Articles

Muscle Response to IL-6 Defective in Type 2 Diabetes

Last Updated: October 25, 2012.

 

Skeletal muscle cells display selective IL-6 resistance for glucose, but not lipid, metabolism

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Skeletal muscle cells from people with type 2 diabetes have defects in glucose metabolism but have normal lipid metabolism after treatment with interleukin-6, according to a study published online Oct. 18 in Diabetes.

THURSDAY, Oct. 25 (HealthDay News) -- Skeletal muscle cells from people with type 2 diabetes have defects in glucose metabolism but have normal lipid metabolism after treatment with interleukin-6 (IL-6), according to a study published online Oct. 18 in Diabetes.

Noting that IL-6 both enhances and inhibits the action of insulin, Lake Q. Jiang, from the Karolinska Institutet in Stockholm, and colleagues investigated how IL-6 affected glucose and lipid metabolism in cultured myotubes from people with normal glucose tolerance and from people with type 2 diabetes.

The researchers found that, in myotubes from people with normal glucose tolerance, IL-6 treatment increased glycogen synthesis, glucose uptake, and phosphorylation of signal transducer and activator of transcription 3 (STAT3). In contrast, IL-6 had no effect on glucose metabolism or STAT3 signaling but did increase expression of suppressor of cytokine signaling 3 in people with type 2 diabetes. IL-6 increased fatty acid oxidation in myotubes from both groups. Cultured myotubes from both groups had similar levels of IL-6, IL-6 receptor, and glycoprotein 130, as well as similar IL-6 secretion.

"In summary, skeletal muscle cells from type 2 diabetic patients display selective IL-6 resistance for glucose rather than lipid metabolism," Jiang and colleagues conclude. "IL-6 appears to play a differential role in regulating metabolism in type 2 diabetic patients compared with normal glucose-tolerant subjects."

The study was funded in part by the Novo Nordisk Research Foundation.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Negative Pigment Network Able to Distinguish Melanoma Next: Laser + Bipolar Resection Helpful for Large Prostates

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.