Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Oncology | Pathology | Pharmacy | Journal

Back to Journal Articles

Potential Biomarker, Drug Target ID’d for Adult Leukemia

Last Updated: October 29, 2012.

 

Tumors from adults with B-cell precursor acute lymphoblastic leukemia have epigenetic changes

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Tumors from adults with B-cell precursor acute lymphoblastic leukemia have epigenetic changes, leading to the identification of a potential biomarker and a possible drug target, according to research published online Oct. 29 in Cancer Discovery.

MONDAY, Oct. 29 (HealthDay News) -- Tumors from adults with B-cell precursor acute lymphoblastic leukemia (B-ALL) have epigenetic changes, leading to the identification of a potential biomarker and a possible drug target, according to research published online Oct. 29 in Cancer Discovery.

Huimin Geng, Ph.D., from the Weill Medical College of Cornell University in New York City, and colleagues conducted DNA methylation and gene expression profiling on tumor samples from 215 adults with B-ALL who were participating in a phase III clinical trial, as well as normal control B cells.

The researchers found that, in B-ALL positive for the BCR-ABL1 fusion, aberrant cytosine methylation patterning was associated with overexpression of IL2RA (CD25). The clinical trial showed that CD25 expression was associated with a poor outcome, regardless of BCR-ABL1 status. In B-ALL positive for the E2A-PBX1 fusion, aberrant DNA methylation patterning was associated with direct fusion protein binding. MLL rearrangements were associated with several epigenetic changes, most notably targeting oncogenic BCL6, and blockade or loss of function of BCL6 suppressed proliferation and survival of cells with MLL rearrangements.

"We observed that aberrant epigenetic regulation occurs universally and is distributed to specific gene sets in genetically defined B-ALL subtypes associated with poor outcomes," Geng and colleagues conclude. "We expect these studies to trigger therapeutic trials of BCL6 inhibitors in MLL leukemia and the application of CD25 as a putative biomarker for risk stratification in B-ALLs."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Hypnosis Cuts Hot Flashes in Postmenopausal Women Next: Smoke-Free Laws Linked to Fewer Hospital Admissions

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.