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Category: Endocrinology | Monthly Briefing

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October 2012 Briefing - Diabetes & Endocrinology

Last Updated: November 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for October 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Once-Yearly Zoledronic Acid Benefits Men With Osteoporosis

WEDNESDAY, Oct. 31 (HealthDay News) -- For men with osteoporosis, a once-yearly infusion with zoledronic acid is associated with fewer vertebral fractures and improved bone health compared with placebo, according to a study published in the Nov. 1 issue of the New England Journal of Medicine.

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Risk Factors for Childhood Overweight ID'd in Infancy

WEDNESDAY, Oct. 31 (HealthDay News) -- Risk factors for childhood overweight are identifiable during infancy, and include maternal pre-pregnancy weight, infant birth weight and weight gain, and maternal smoking during pregnancy, according to research published online Oct. 29 in the Archives of Disease in Childhood.

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Fenofibrate/Simvastatin Benefit in Dyslipidemia Explored

WEDNESDAY, Oct. 31 (HealthDay News) -- Combination treatment with fenofibrate and simvastatin (FENO-S) significantly reduces postprandial (PP) triglyceride (TG) levels compared with simvastatin alone in all subjects, regardless of fasting TG level, but reduces atherogenic apolipoprotein (apo) B48 particles only in those with increased fasting TG levels, according to research published online Oct. 25 in Diabetes Care.

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U.S. Medicare Spending on Elderly Has Outpaced Canada's

TUESDAY, Oct. 30 (HealthDay News) -- U.S. Medicare spending on the elderly has grown nearly three times faster than its Canadian counterpart, according to a study published online Oct. 29 in the Archives of Internal Medicine.

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Resveratrol Has No Metabolic Benefit for Non-Obese Women

TUESDAY, Oct. 30 (HealthDay News) -- Resveratrol supplementation does not improve plasma lipids or insulin sensitivity in non-obese women, nor does it affect its putative targets in fat or muscle, according to a study published online Oct. 25 in Cell Metabolism.

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Overweight, Obese Teens at Risk for End-Stage Renal Disease

TUESDAY, Oct. 30 (HealthDay News) -- Being overweight or obese as an adolescent is significantly associated with increased risk for all-cause treated end-stage renal disease (ESRD), according to a study published online Oct. 29 in the Archives of Internal Medicine.

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Early Intervention Key in Obesity Auto-Perpetuation Prevention

MONDAY, Oct. 29 (HealthDay News) -- Prevention of the allostatic overload that auto-perpetuates obesity requires early genetic intervention, according to an experimental study published online Oct. 24 in the Journal of Clinical Investigation.

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Old Order Amish Children More Active, Less Likely Overweight

MONDAY, Oct. 29 (HealthDay News) -- Old Order Amish (OOA) children are less likely to be overweight and are more physically active than other children, according to a study published online Oct. 23 in Diabetes Care.

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Impact of Partial Sleep Deprivation on Weight Explored

FRIDAY, Oct. 26 (HealthDay News) -- Various mechanisms may be involved in the correlation between sleep deprivation and obesity, including disruption of appetitive hormones and influence on energy intake, according to research published in the November issue of the Journal of the Academy of Nutrition and Dietetics.

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Insulin Sensitivity Normally Highest After Breakfast

FRIDAY, Oct. 26 (HealthDay News) -- In healthy people without diabetes, glucose responsiveness tends to be higher after breakfast, which may have implications for the design of closed-loop insulin delivery systems for diabetes patients, according to a study published in the November issue of Diabetes.

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Independent Link for Child BMI, Adult Cardio Risk Questioned

FRIDAY, Oct. 26 (HealthDay News) -- Although the evidence for an association between childhood body mass index (BMI) and cardiovascular outcomes seems consistent, few studies examine this association independent of adult BMI, according to research published in the November issue of Obesity Reviews.

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Muscle Response to IL-6 Defective in Type 2 Diabetes

THURSDAY, Oct. 25 (HealthDay News) -- Skeletal muscle cells from people with type 2 diabetes have defects in glucose metabolism but have normal lipid metabolism after treatment with interleukin-6 (IL-6), according to a study published online Oct. 18 in Diabetes.

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Insulin Glargine's Main Metabolic Effect As Metabolite M1

THURSDAY, Oct. 25 (HealthDay News) -- For patients with type 2 diabetes, following administration of a subcutaneous injection of a therapeutic dose of insulin glargine, glargine is minimally detectable in blood, and most of the plasma insulin concentration is in the form of its metabolite M1, according to a study published online Oct. 18 in Diabetes Care.

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Better Obesity Risk Prediction With Hip and Waist Measures

WEDNESDAY, Oct. 24 (HealthDay News) -- Inclusion of both waist and hip circumference as separate anthropometric measurements may improve risk prediction for obesity-related mortality and morbidity, according to research published online Oct. 17 in Obesity Reviews.

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Hormonal Changes at Menopause Up Abdominal Obesity

WEDNESDAY, Oct. 24 (HealthDay News) -- The increase in total body fat and abdominal fat seen at menopause is due to the hormonal changes taking place, which can be improved by estrogen treatment, according to a study published in the October issue of Climacteric.

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Family Obesity Approach Promising for Black Girls

WEDNESDAY, Oct. 24 (HealthDay News) -- Obesity interventions that include family involvement may be a promising approach for targeting African-American girls, but more research is required, according to the results of a systematic literature review published online Oct. 12 in Obesity Reviews.

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Genuine Very Large Effects in Trials Rare in Medicine

TUESDAY, Oct. 23 (HealthDay News) -- Large treatment effects are most likely to be found in small studies, with the effect diminishing with additional trials, according to research published in the Oct. 24 issue of the Journal of the American Medical Association.

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Legume-Rich Diet Can Improve Glycemic Control in T2DM

TUESDAY, Oct. 23 (HealthDay News) -- For individuals with type 2 diabetes mellitus, consumption of a low glycemic index (GI) diet incorporating legumes is associated with improved glycemic control and a reduction in the risk of coronary heart disease, according to a study published online Oct. 22 in the Archives of Internal Medicine.

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Genetic Predisposition to Diabetes Ups Risk of CVD

TUESDAY, Oct. 23 (HealthDay News) -- For patients with type 2 diabetes (T2D), having a genetic predisposition towards the disease is associated with an increased risk of cardiovascular disease (CVD), according to a study published online Oct. 15 in Diabetes Care.

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Parental Stress Linked to Obesity in Offspring

MONDAY, Oct. 22 (HealthDay News) -- The number of parent stressors is associated with child obesity, and parent-perceived stress impacts related behaviors, specifically fast-food consumption, according to a study published online Oct. 22 in Pediatrics.

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Obese Young Males Have Lower Testosterone Levels

MONDAY, Oct. 22 (HealthDay News) -- Obesity in young males is associated with low testosterone concentrations, according to a study published online Sept. 13 in Clinical Endocrinology.

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Effects of Bariatric Surgery on Heart Function, Structure ID'd

MONDAY, Oct. 22 (HealthDay News) -- Bariatric surgery is associated with improvement or resolution of preexisting hypertension, hyperlipidemia, and diabetes in a majority of participants, as well as with improvements in left ventricular hypertrophy and diastolic function, according to research published online Oct. 17 in Heart.

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Novel Liver X Receptor Agonist Benefits Diabetic Nephropathy

MONDAY, Oct. 22 (HealthDay News) -- A new therapeutic target that activates the liver X receptor (LXR) suppresses expression of inflammatory genes, including osteopontin, and improves kidney health and function in a mouse model of diabetes, according to a study published online Oct. 18 in the Journal of the American Society of Nephrology.

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Sedentary Time Linked to Increased Diabetes Risk

FRIDAY, Oct. 19 (HealthDay News) -- Greater sedentary time is associated with increased risk of diabetes, cardiovascular disease, and cardiovascular and all-cause mortality, with the most consistent associations seen for diabetes, according to a review and meta-analysis published in the November issue of Diabetologia.

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Higher Calcium Intake May Lower Risk of Hyperparathyroidism

FRIDAY, Oct. 19 (HealthDay News) -- Women consuming higher levels of calcium are at lower risk of primary hyperparathyroidism, according to a study published online Oct. 18 in BMJ.

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Treating Obstructive Sleep Apnea Tied to Lasting BP Drop

THURSDAY, Oct. 18 (HealthDay News) -- In men with obstructive sleep apnea (OSA) and preexisting systemic hypertension or type 2 diabetes, positive airway pressure (PAP) is associated with a significant and sustained reduction in both systolic and diastolic blood pressure (BP), according to research published in the Oct. 15 issue of the Journal of Clinical Sleep Medicine.

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Return to Work Difficult for Doctors on Sick Leave

THURSDAY, Oct. 18 (HealthDay News) -- Returning to work after a prolonged sick leave for physical or mental health problems, or drug or alcohol problems, is difficult for doctors, who describe self-stigmatization and fear a negative response on their return to work, according to a study published online Oct. 15 in BMJ Open.

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Exercise Stimulates Adiponectin, Raises HDL Levels

THURSDAY, Oct. 18 (HealthDay News) -- Intensive lifestyle intervention for weight loss (ILI) significantly improves high-density lipoprotein cholesterol (HDL-C) levels in overweight and obese individuals with type 2 diabetes, which is partially mediated by stimulation of adiponectin production, according to a study published online Sept. 5 in the Journal of Lipid Research.

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Direct Link ID'd for Sleep Deprivation, Insulin Sensitivity

TUESDAY, Oct. 16 (HealthDay News) -- Even short-term sleep restriction results in an insulin-resistant state in adipocytes, according to research published in the Oct. 16 issue of the Annals of Internal Medicine.

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Zonisamide 400 mg Enhances Weight Loss for Obese

MONDAY, Oct. 15 (HealthDay News) -- The antiepileptic drug zonisamide, at a dosage of 400 mg per day, is associated with enhanced weight loss for obese patients when combined with diet and lifestyle counseling, but the incidence of adverse events is high, according to a study published online Oct. 15 in the Archives of Internal Medicine.

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Study Suggests How Obesity Promotes Tumor Growth

MONDAY, Oct. 15 (HealthDay News) -- Fat cells can be recruited to tumors where they contribute to the growth of tumor blood vessels, according to a study in the Oct. 15 issue of Cancer Research.

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Diabetes Independently Predicts Severe Osteoarthritis

FRIDAY, Oct. 12 (HealthDay News) -- Type 2 diabetes is independently associated with increased risk of severe osteoarthritis, and independently predicts arthroplasty, according to a study published online Sept. 21 in Diabetes Care.

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Gastro Illness in Infancy Linked to Islet Autoimmunity

FRIDAY, Oct. 12 (HealthDay News) -- Gastrointestinal illnesses are associated with increased risk of islet autoimmunity (IA) among children who are exposed to wheat or barley either early or late in infancy, according to a study published online Oct. 5 in Diabetes Care.

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Add-On Therapy Doesn't Improve Weight Watchers' Results

THURSDAY, Oct. 11 (HealthDay News) -- The addition of behavioral weight loss (BWL) treatment to the commercial Weight Watchers (WW) weight-loss program does not improve weight loss outcomes, according to a study published online Oct. 8 in Obesity.

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Use of More Costly Diabetes Medications Varies Widely

THURSDAY, Oct. 11 (HealthDay News) -- Even within an integrated Veterans Affairs (VA) system with a uniform national formulary and established criteria for drug use, there is substantial variation in the use of thiazolidinediones and long-acting insulin analogues among veterans with type 2 diabetes mellitus (T2DM), according to a research letter published online Oct. 8 in the Archives of Internal Medicine.

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Exercise Intensity Affects Risk of Metabolic Syndrome

THURSDAY, Oct. 11 (HealthDay News) -- Leisure-time physical activity (LTPA) correlates with a reduction in the risk of metabolic syndrome (MetS), with the intensity of exercise, rather than the volume, impacting the risk, according to a study published online Oct. 8 in BMJ Open.

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Interventions Helpful for Breast Cancer-Induced Menopause

THURSDAY, Oct. 11 (HealthDay News) -- Cognitive behavioral therapy (CBT) and physical exercise improve endocrine and urinary symptoms as well as physical functioning in patients with breast cancer treatment-induced menopause, according to research published online Oct. 8 in the Journal of Clinical Oncology.

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Diverse Forms of Distress Have Distinct Impact in Diabetes

WEDNESDAY, Oct. 10 (HealthDay News) -- In primary care patients with type 2 diabetes, depressive symptoms (DS) are predictive of future lifestyle-oriented self-management behaviors, while diabetes-related distress (DRD) predicts glycemic control, possibly due to medication adherence, according to research published online Oct. 1 in Diabetes Care.

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Proneurotensin Linked to Increased Disease, Death Risk

TUESDAY, Oct. 9 (HealthDay News) -- Plasma levels of proneurotensin are associated with the future development of diabetes, cardiovascular disease, and cardiovascular and total mortality, as well as breast cancer in women, according to a study published in the Oct. 10 issue of the Journal of the American Medical Association.

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Mathematical Model Can Help Predict Chances of Conception

TUESDAY, Oct. 9 (HealthDay News) -- A new mathematical model can help predict the chances that a couple will conceive based on how many months they have been trying to conceive, according to a study published online Oct. 4 in PLoS One.

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Pre-Op Factors Predict Post-Gastric Op Glycemic Response

MONDAY, Oct. 8 (HealthDay News) -- The glycemic response to gastric bypass surgery can be predicted in Chinese patients with type 2 diabetes by three preoperative factors, according to a study published online Oct. 1 in Diabetes Care.

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Low Vitamin D Linked to Mortality in Black, White Elderly

MONDAY, Oct. 8 (HealthDay News) -- Low levels of 25-hydroxyvitamin D (25[OH]D) and high levels of parathyroid hormone (PTH) are associated with increased mortality in older black and white adults, according to a study published online Aug. 31 in the Journal of Clinical Endocrinology & Metabolism.

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Monoclonal Antibody Effective Therapy for Diabetic Retinopathy

FRIDAY, Oct. 5 (HealthDay News) -- An antibody can reduce retinal vascular leakage and inflammation in rat models of diabetic retinopathy, according to a study published online Oct. 1 in Diabetes.

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Bisphenol A Linked to Thyroid Changes During Pregnancy

FRIDAY, Oct. 5 (HealthDay News) -- Maternal exposure to bisphenol A (BPA) during pregnancy is related to reduced free thyroxine (T4) in the mother and lower thyroid-stimulating hormone (TSH) in male neonates, according to research published online Oct. 4 in Environmental Health Perspectives.

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Moderate Drinking Ups A-Fib Risk in Adults at Risk for CVD

THURSDAY, Oct. 4 (HealthDay News) -- In older people with heart disease or advanced diabetes with organ damage, moderate alcohol consumption increases the risk of atrial fibrillation, according to research published online Oct. 1 in CMAJ, the journal of the Canadian Medical Association.

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Screening for Type 2 Diabetes Not Linked to Drop in Mortality

THURSDAY, Oct. 4 (HealthDay News) -- For middle-aged adults at high risk of type 2 diabetes, invitation to screening is not associated with a decrease in mortality, according to a study published online Oct. 4 in The Lancet.

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EHRs Linked to Improved Care, Outcomes in Diabetes

THURSDAY, Oct. 4 (HealthDay News) -- Use of outpatient electronic health records (EHRs) is associated with improved clinical care and outcomes in patients with diabetes, according to a study published in the Oct. 2 issue of the Annals of Internal Medicine.

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Lower-Extremity Amputations in Diabetes Down in Scotland

THURSDAY, Oct. 4 (HealthDay News) -- In Scotland, from 2004 to 2008, the incidence of all lower-extremity amputations (LEAs) due to diabetes was significantly reduced by about 30 percent, and the rate of major LEAs was reduced by about 40 percent, according to a study published online Sept. 25 in Diabetes Care.

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Limiting the Problem of Missing Data Urged for Clinical Trials

WEDNESDAY, Oct. 3 (HealthDay News) -- Missing data compromise inferences from clinical trials, and due to the problematic nature of compensation with analysis methods, the importance of avoiding missing data in clinical trials is paramount, according to a special report published in the Oct. 4 issue of the New England Journal of Medicine.

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Fertility Treatment Linked to Multiple Sclerosis Worsening

WEDNESDAY, Oct. 3 (HealthDay News) -- Fertility treatment is associated with a higher risk of multiple sclerosis (MS) exacerbations, which is linked to the increase in reproductive hormones affecting immune function, according to a study published online Oct. 3 in the Annals of Neurology.

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Observation Units Could Save $3.1 Billion Nationally Per Year

TUESDAY, Oct. 2 (HealthDay News) -- The addition of observation units to U.S. hospitals which do not currently have them in place could save $3.1 billion nationally per year in health care costs, according to a study published online Sept. 26 in Health Affairs.

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Patients Benefit From Access to Physician Notes

MONDAY, Oct. 1 (HealthDay News) -- Patients report clinically relevant benefits and minimal concerns, while doctors do not experience negative consequences, from allowing patient access to visit notes, according to a study published in the Oct. 1 issue of the Annals of Internal Medicine.

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