Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for October 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
U.S. Medicare Spending on Elderly Has Outpaced Canada's
TUESDAY, Oct. 30 (HealthDay News) -- U.S. Medicare spending on the elderly has grown nearly three times faster than its Canadian counterpart, according to a study published online Oct. 29 in the Archives of Internal Medicine.
Burden of Gastrointestinal Disease in U.S. Substantial
MONDAY, Oct. 29 (HealthDay News) -- Gastrointestinal diseases account for substantial morbidity, mortality, and cost in the United States, according to research published in the November issue of Gastroenterology.
Buspirone Improves Symptoms in Functional Dyspepsia
MONDAY, Oct. 29 (HealthDay News) -- Buspirone, a 5-hydroxytryptamine 1A receptor agonist, improves symptom severity in patients with functional dyspepsia (FD), according to a proof-of-concept study published in the November issue of Clinical Gastroenterology and Hepatology.
Meta-Analysis: Antivirals Reduce Risk of Liver Cancer in Hep C
THURSDAY, Oct. 25 (HealthDay News) -- Antiviral treatment does significantly reduce the risk of developing liver cancer for patients with chronic hepatitis C infection, particularly in virological responders, according to a meta-analysis published online Oct. 22 in BMJ Open.
Intestinal Bacteria Profile Altered in Pediatric Crohn's
THURSDAY, Oct. 25 (HealthDay News) -- Pediatric patients with Crohn's disease have altered levels of particular fecal bacterial species, some of which correlate with disease severity, according to a study published in the October issue of the Journal of Clinical Microbiology.
Aspirin Improves Survival for CRC With PIK3CA Mutation
WEDNESDAY, Oct. 24 (HealthDay News) -- Among patients with colorectal cancer (CRC), regular use of aspirin after diagnosis is associated with longer survival for those with the mutated phosphatidylinositol-4,5-bisphosphonate 3-kinase, catalytic subunit alpha polypeptide gene (PIK3CA), according to a study published in the Oct. 25 issue of the New England Journal of Medicine.
Decrease in CRC Resections Tied to Medicare-Covered Screening
WEDNESDAY, Oct. 24 (HealthDay News) -- The rates of resection for distal and proximal colorectal cancer (CRC) decreased from 1993 to 2009, with rates of proximal resection decreasing significantly from 2002, after implementation of Medicare payment for screening colonoscopy, according to a study published in the November issue of Gastroenterology.
Genuine Very Large Effects in Trials Rare in Medicine
TUESDAY, Oct. 23 (HealthDay News) -- Large treatment effects are most likely to be found in small studies, with the effect diminishing with additional trials, according to research published in the Oct. 24 issue of the Journal of the American Medical Association.
TNF Inhibitor Use Doesn't Up Short-Term Cancer Incidence
MONDAY, Oct. 22 (HealthDay News) -- Treatment of chronic immune-mediated diseases with tumor necrosis factor (TNF) inhibitors does not result in any short-term increase in cancer incidence, compared with other commonly used therapies for these conditions, according to a study published online Oct. 10 in Arthritis & Rheumatism.
Common Liver Tests Can Predict Liver Cancer Risk
FRIDAY, Oct. 19 (HealthDay News) -- Common liver function tests, including measurement of alanine transaminase (ALT) and aspartate transaminase (AST) levels, can be used to reliably predict hepatocellular carcinoma (HCC) risk in the general population with average or unknown risk, according to research published in the Oct. 17 issue of the Journal of the National Cancer Institute.
Return to Work Difficult for Doctors on Sick Leave
THURSDAY, Oct. 18 (HealthDay News) -- Returning to work after a prolonged sick leave for physical or mental health problems, or drug or alcohol problems, is difficult for doctors, who describe self-stigmatization and fear a negative response on their return to work, according to a study published online Oct. 15 in BMJ Open.
Ustekinumab Active for Some With Refractory Crohn's
THURSDAY, Oct. 18 (HealthDay News) -- Patients with moderate-to-severe Crohn's disease refractory to tumor necrosis factor (TNF) antagonists who receive ustekinumab induction therapy have a higher clinical response rate and, during maintenance therapy, achieve significantly higher response and remission rates compared to patients receiving placebo, according to a study published in the Oct. 18 issue of the New England Journal of Medicine.
Universal Screening Modestly Ups Lynch Syndrome Diagnosis
WEDNESDAY, Oct. 17 (HealthDay News) -- In patients with colorectal cancer, universal testing for mutations in genes associated with Lynch syndrome, the most common form of hereditary colorectal cancer, has modestly better diagnostic sensitivity than other strategies, according to a study published in the Oct. 17 issue of the Journal of the American Medical Association.
Increased Substance Use Seen After Weight Loss Surgery
TUESDAY, Oct. 16 (HealthDay News) -- Patients who undergo weight loss surgery may have an increased risk for substance use after surgery, according to a study published online Oct. 15 in the Archives of Surgery.
Coffee Speeds Time to First Bowel Action Post Colectomy
MONDAY, Oct. 15 (HealthDay News) -- Following colectomy, coffee consumption is safe and correlates with a shorter time to first bowel movement, according to a study published in the November issue of the British Journal of Surgery.
B-Vitamin Supplement Doesn't Lower Colorectal Cancer Risk
MONDAY, Oct. 15 (HealthDay News) -- A combination of folic acid and vitamins B6 and B12 supplementation does not reduce the risk of colorectal adenoma among high-risk women, according to a study published online Oct. 12 in the Journal of the National Cancer Institute.
Gastro Illness in Infancy Linked to Islet Autoimmunity
FRIDAY, Oct. 12 (HealthDay News) -- Gastrointestinal illnesses are associated with increased risk of islet autoimmunity (IA) among children who are exposed to wheat or barley either early or late in infancy, according to a study published online Oct. 5 in Diabetes Care.
Prior Alcohol Consumption Does Not Impair HCV Treatment
THURSDAY, Oct. 11 (HealthDay News) -- For patients with hepatitis C virus (HCV) treated with pegylated interferon-alpha and ribavirin (P/R), drinking patterns and the amount of alcohol consumed before treatment do not impact treatment success, according to a study published in the October issue of Hepatology.
CT Use Up for Children With Abdominal Pain Seen in ER
MONDAY, Oct. 8 (HealthDay News) -- For children presenting to the emergency department with abdominal pain, there was a dramatic increase in computed tomography (CT) use from 1998 to 2008, according to a study published online Oct. 8 in Pediatrics.
Pre-Op Factors Predict Post-Gastric Op Glycemic Response
MONDAY, Oct. 8 (HealthDay News) -- The glycemic response to gastric bypass surgery can be predicted in Chinese patients with type 2 diabetes by three preoperative factors, according to a study published online Oct. 1 in Diabetes Care.
Anal Cancer Increase Linked to HIV Infection Only in Men
FRIDAY, Oct. 5 (HealthDay News) -- The rising incidence of anal cancer since 1980 in the United States is strongly impacted by HIV infection in men but not women, according to a study published online Oct. 5 in the Journal of the National Cancer Institute.
HCV Treatment in Prison Could Be Key Public Health Measure
FRIDAY, Oct. 5 (HealthDay News) -- Incarcerated patients with hepatitis C virus (HCV) infection are as likely to be treated and to achieve a sustained viral response (SVR) as non-incarcerated patients, according to research published in the October issue of Hepatology.
Limiting the Problem of Missing Data Urged for Clinical Trials
WEDNESDAY, Oct. 3 (HealthDay News) -- Missing data compromise inferences from clinical trials, and due to the problematic nature of compensation with analysis methods, the importance of avoiding missing data in clinical trials is paramount, according to a special report published in the Oct. 4 issue of the New England Journal of Medicine.
Observation Units Could Save $3.1 Billion Nationally Per Year
TUESDAY, Oct. 2 (HealthDay News) -- The addition of observation units to U.S. hospitals which do not currently have them in place could save $3.1 billion nationally per year in health care costs, according to a study published online Sept. 26 in Health Affairs.
New Database IDs Variants Linked to Colorectal Cancer
TUESDAY, Oct. 2 (HealthDay News) -- Sixteen variants at 13 loci have been identified as having a highly credible association with colorectal cancer, according to research published online Sept. 26 in the Journal of the National Cancer Institute.
Higher Risk of Esophageal, Stomach Cancer With AIDS
MONDAY, Oct. 1 (HealthDay News) -- There is an increased risk of esophageal and stomach cancers among people with AIDS, according to a study published in the October issue of Gastroenterology.
Patients Benefit From Access to Physician Notes
MONDAY, Oct. 1 (HealthDay News) -- Patients report clinically relevant benefits and minimal concerns, while doctors do not experience negative consequences, from allowing patient access to visit notes, according to a study published in the Oct. 1 issue of the Annals of Internal Medicine.
Humira's Approval Widened to Include Ulcerative Colitis
MONDAY, Oct. 1 (HealthDay News) -- Humira (adalimumab) has been approved by the U.S. Food and Drug Administration to treat moderate-to-severe ulcerative colitis in adults, the agency said Friday.
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