Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Oncology | Pathology | Urology | Journal

Back to Journal Articles

Differential miRNA Expression IDs Urothelial Cancer Grade

Last Updated: November 01, 2012.

 

Expression of four microRNAs may serve as potential diagnostic or prognostic biomarkers

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Four microRNAs are differentially expressed in low-grade noninvasive and high-grade invasive urothelial carcinoma, and show potential as diagnostic or prognostic markers, according to a study published in the November issue of The Journal of Urology.

THURSDAY, Nov. 1 (HealthDay News) -- Four microRNAs (miRNAs) are differentially expressed in low-grade noninvasive (pTa) and high-grade invasive (pT2-3) urothelial carcinoma, and show potential as diagnostic or prognostic markers, according to a study published in the November issue of The Journal of Urology.

Nelson Dip, from the University of São Paulo Medical School in Brazil, and colleagues examined expression of 14 miRNAs in urothelial carcinoma. Quantitative reverse transcriptase-polymerase chain reaction was performed on surgical specimens from 30 patients with low-grade pTa and 30 with high-grade pT2-3 urothelial carcinoma, and expression was compared with normal bladder tissue from five patients who underwent surgery for benign prostatic hyperplasia.

The researchers found that, in 100 percent of low-grade pTa specimens, miR-100 was significantly underexpressed, while miR-10a was significantly overexpressed in 73.3 percent. In high-grade pT2-3 disease, miR-21 and miR-205 were significantly overexpressed. Expression of other miRNAs was similar to that of normal bladder tissue or was underexpressed in each tumor group. For patients with low-grade pTa urothelial carcinoma, miR-21 over expression correlated with shorter disease-free survival. For patients with high-grade pT2-3 urothelial carcinoma, increased miR-10a levels correlated with shorter disease-free and disease-specific survival.

"Low-grade pTa and high-grade pT2-3 urothelial carcinomas show differences with respect to miRNA expression that could be incorporated into the well-known carcinogenic pathway," the authors write. "Aberrant miRNA levels could be used as new biomarkers to better treat patients with bladder cancer or those susceptible to the neoplasm."

Abstract
Full Text

Copyright © 2012 HealthDay. All rights reserved.


Previous: Neuraxial Anesthesia Beneficial for Bilateral Knee Arthroplasty Next: Mutant Tumor Suppressor Gene ID'd in Mucinous Ovarian Tumors

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.