Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Dermatology | Oncology | Pathology | Journal

Back to Journal Articles

UV-Independent Pathway ID’d in Those at Risk for Melanoma

Last Updated: November 01, 2012.

 

Pheomelanin pigment pathway plays role in UV-radiation-independent carcinogenesis in mice

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Mice with an inactivating mutation in the melanocortin 1 receptor gene, which controls pigment production, have a phenotype similar to red hair/fair skin in humans; these mice have an increased risk of melanoma, even in the absence of ultraviolet radiation exposure, which may act by a mechanism of oxidative damage, according to a study published online Oct. 31 in Nature.

THURSDAY, Nov. 1 (HealthDay News) -- Mice with an inactivating mutation in the melanocortin 1 receptor (Mc1r) gene, which controls pigment production, have a phenotype similar to red hair/fair skin in humans; these mice have an increased risk of melanoma, even in the absence of ultraviolet radiation exposure, which may act by a mechanism of oxidative damage, according to a study published online Oct. 31 in Nature.

Devarati Mitra, from the Massachusetts General Hospital in Charlestown, and colleagues used genetically engineered mice carrying an inactivating mutation in the Mc1r gene and introduced a conditional, melanocyte-targeted allele of the most common melanoma oncoprotein, BRAFV600E to investigate ultraviolet-radiation-independent carcinogenesis.

The researchers found that, without providing additional gene aberrations or ultraviolet radiation exposure, there was a high incidence of invasive melanomas in these mice. Following introduction of an albino allele to ablate all pigment production on the Mc1re/e background, selective absence of pheomelanin synthesis was found to be protective against the development of melanoma. Compared with albino-Mc1re/e mouse skin, normal-Mc1re/e mouse skin was found to have significantly greater oxidative DNA and lipid damage.

"These data suggest that the pheomelanin pigment pathway produces ultraviolet-radiation-independent carcinogenic contributions to melanomagenesis by a mechanism of oxidative damage," the authors write. "Although protection from ultraviolet radiation remains important, additional strategies may be required for optimal melanoma prevention."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Patch Testing Can ID Food, Additives That Contribute to IBS Next: Obesity Ups Complications After Total Knee Arthroplasty

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.