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Testosterone Doesn’t Add to Erectile Response With Sildenafil

Last Updated: November 19, 2012.

For men with erectile dysfunction and low testosterone levels, the addition of testosterone to sildenafil is not superior to sildenafil alone for improving erectile function, according to a study published in the Nov. 20 issue of the Annals of Internal Medicine.

MONDAY, Nov. 19 (HealthDay News) -- For men with erectile dysfunction and low testosterone levels, the addition of testosterone to sildenafil is not superior to sildenafil alone for improving erectile function, according to a study published in the Nov. 20 issue of the Annals of Internal Medicine.

Matthew Spitzer, M.D., from the Boston University School of Medicine, and colleagues examined whether addition of testosterone to sildenafil therapy correlates with improved erectile response in 40- to 70-year-old men with erectile dysfunction and low testosterone levels. One hundred forty participants were randomly allocated to receive 14 weeks of daily transdermal gel containing 10-gram testosterone or placebo (70 participants each).

The researchers found that administration of sildenafil alone correlated with a considerable increase in erectile function domain scores, with no significant difference between the groups. In younger men, more obese men, and men with lower baseline testosterone levels or inadequate response to sildenafil alone, similar results were seen for other domains of sexual function. Both groups had similar frequency of adverse events.

"In men with erectile dysfunction who had low testosterone levels, the addition of a replacement dose of testosterone to an optimized dose of sildenafil was not associated with greater improvement in erectile function than that associated with addition of placebo gel," the authors write.

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