Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Gynecology | Nursing | Pediatrics | Pharmacy | Journal

Back to Journal Articles

Fetal NSAID Exposure Not Tied to Persistent Pulmonary HTN

Last Updated: December 03, 2012.

 

Neither NSAIDS overall, nor ibuprofen exposure tied to increased risk of hypertension of newborn

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
There appears to be no association between persistent pulmonary hypertension of the newborn and gestational exposure to nonsteroidal anti-inflammatory drugs, including ibuprofen, according to a study published online Dec. 3 in Pediatrics.

MONDAY, Dec. 3 (HealthDay News) -- There appears to be no association between persistent pulmonary hypertension of the newborn (PPHN) and gestational exposure to nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, according to a study published online Dec. 3 in Pediatrics.

To examine the correlation between antenatal exposure to NSAIDs and the risk for PPHN, Linda J. Van Marter, M.D., M.P.H., from Boston Children's Hospital, and colleagues interviewed 377 women whose infants had PPHN, along with 836 control mother/infant pairs matched by hospital and delivery date. Questions included information about prescribed and over-the-counter medications used during pregnancy.

The researchers found that 8.8 percent of infants with PPHN were exposed to any NSAID during the third trimester, compared with 9.6 percent of controls (odds ratio, 0.8; 95 percent confidence interval, 0.5 to 1.3). The odds of PPHN were elevated for infants whose mothers consumed aspirin during the third trimester, but the lower 95 percent confidence interval included the null. Neither ibuprofen use during the third trimester nor non-aspirin NSAIDs at any time during pregnancy was associated with an increased risk of PPHN. There was also no association found between third-trimester acetaminophen exposure and the occurrence of PPHN.

"This large multicenter epidemiologic study of PPHN risk revealed no evidence to support the hypothesis that maternal consumption during pregnancy of NSAIDs overall or ibuprofen in particular is associated with PPHN risk," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Recent Increase in Adverse TMP-SMX Reactions in Children Next: Improved Survival Seen in Ovarian CA With Metformin Use

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.