Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Family Medicine | Internal Medicine | Nursing | Oncology | Pharmacy | Pulmonology | Journal

Back to Journal Articles

Use of Beta-Blockers Tied to Improved Lung Cancer Survival

Last Updated: January 11, 2013.

 

Overall, distant metastasis-free, and disease-free survival all improved for patients with NSCLC

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
For patients with non-small-cell lung cancer, intake of beta-blockers is associated with improved survival, according to a study published online Jan. 8 in the Annals of Oncology.

FRIDAY, Jan. 11 (HealthDay News) -- For patients with non-small-cell lung cancer (NSCLC), intake of beta-blockers is associated with improved survival, according to a study published online Jan. 8 in the Annals of Oncology.

To examine the association between beta-blocker use and survival, H.M. Wang, from the University of Texas MD Anderson Cancer Center in Houston, and colleagues retrospectively reviewed charts from 722 patients with NSCLC who received definitive radiotherapy. Among the patients, 155 were taking beta-blockers and 567 were not.

In univariate analysis, the researchers found that distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS), were significantly improved for patients taking beta-blockers compared to patients not taking beta-blockers. After adjustment for multiple variables, including age, Karnofsky performance score, stage, histology type, concurrent chemotherapy, radiation dose, gross tumor volume, hypertension, chronic obstructive pulmonary disease, and aspirin use, there were significant correlations for beta-blocker intake with DMFS (hazard ratio [HR], 0.67), DFS (HR, 0.74), and OS (HR, 0.78). In univariate or multivariate analysis, locoregional progression-free survival was not improved for patients taking beta-blockers.

"These findings are concordant with those of previous preclinical studies, suggesting that beta-blockers have specific effects on the metastatic cascade," the authors write. "Future prospective trials are needed to validate these retrospective findings and establish whether the length and timing of beta-blocker use influence survival outcomes."

Abstract
Full Text

Copyright © 2013 HealthDay. All rights reserved.


Previous: Radiation Therapy Use Low in End-Stage Cancer Next: AAN: Mortality Up for Stroke Survivors With Depression

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.