Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Family Medicine | Internal Medicine | Critical Care | Emergency Medicine | Nursing | Oncology | Pharmacy | Journal

Back to Journal Articles

Moxifloxacin Monotherapy Equivalent to Antibiotic Combo

Last Updated: January 30, 2013.

 

Findings among adult, febrile neutropenic cancer patients at low risk for complications

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Oral monotherapy with moxifloxacin is as efficacious and safe as combination therapy with ciprofloxacin plus amoxicillin/clavulanic acid for treatment of fever in adult patients with cancer and neutropenia who are at low risk of complications, according to a study published online Jan. 28 in the Journal of Clinical Oncology.

WEDNESDAY, Jan. 30 (HealthDay News) -- Oral monotherapy with moxifloxacin is as efficacious and safe as combination therapy with ciprofloxacin plus amoxicillin/clavulanic acid for treatment of fever in adult patients with cancer and neutropenia who are at low risk of complications, according to a study published online Jan. 28 in the Journal of Clinical Oncology.

Winfried V. Kern, M.D., from the University Hospital in Freiburg, Germany, and colleagues conducted a double-blind multicenter study to compare the efficacy and safety of moxifloxacin monotherapy with oral combination therapy for febrile neutropenia in cancer patients with low risk of complications as defined by a Multinational Association for Supportive Care in Cancer score >20. Patients were assigned to receive either moxifloxacin monotherapy or oral ciprofloxacin plus amoxicillin/clavulanic acid.

The researchers found that, among the 333 patients included in the intention-to-treat analysis, therapy success was seen in 80 percent of the patients administered moxifloxacin and 82 percent of the patients administered combination therapy (95 percent confidence interval for the difference, −10 to 8 percent, consistent with equivalence). There were minor differences in tolerability, safety, and reasons for failure, but in the two groups, more than 50 percent of patients were discharged on protocol therapy, with 5 percent readmissions in each group. Survival was 99 percent in both groups.

"In conclusion, the data from this double-blind trial provide evidence that single-drug oral therapy in low-risk febrile neutropenia with moxifloxacin is equivalent to the combination therapy so far considered standard," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Bayer Healthcare, which funded the study.

Abstract
Full Text (subscription or payment may be required)
Editorial

Health News Copyright © 2013 HealthDay. All rights reserved.


Previous: Study Confirms Prolongation of QT Interval With Citalopram Next: Common Obesity Beliefs Often Unsupported by Science

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.