Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Endocrinology | Family Medicine | Nephrology | Nursing | Pediatrics | Pharmacy | Journal

Back to Journal Articles

Growth Hormone Ups Height in Pediatric Dialysis Patients

Last Updated: April 05, 2013.

 

Bone formation rates are higher with growth hormone, regardless of bone histologic features

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
For pediatric dialysis patients, growth hormone (GH) therapy is associated with an increased rate of bone formation and results in greater increases in height, according to research published online April 4 in the Clinical Journal of the American Society of Nephrology.

FRIDAY, April 5 (HealthDay News) -- For pediatric dialysis patients, growth hormone (GH) therapy is associated with an increased rate of bone formation and results in greater increases in height, according to research published online April 4 in the Clinical Journal of the American Society of Nephrology.

Justine Bacchetta, M.D., of the David Geffen School of Medicine at the University of California Los Angeles, and colleagues assessed the effects of GH therapy in 33 pediatric patients with end-stage renal disease (median age, 11.7 years). Participants were randomized to therapy with GH (15 patients) or without GH (18 patients). All patients were further stratified by bone turnover rate and those with high bone turnover also received calcitriol.

The researchers found that, for patients with low bone turnover, treatment with GH was associated with a significant increase in bone formation rate per bone surface (from 15.0 to 154.6 µm²/ µm³ per year). Patients with high bone turnover treated with standard therapy had a significant decrease in bone formation rate per bone surface (from 103.3 to 60.3 µm²/ µm³ per year). The rate was unchanged in the other groups. Regardless of underlying bone histologic features, patients treated with GH had significantly higher bone formation rates and significantly greater increases in height standard deviation scores. Parathyroid hormone levels were similar among the groups.

"GH therapy improves height in pediatric dialysis patients, irrespective of underlying bone histologic features," the authors conclude. "Bone formation rates are higher in GH recipients, and GH therapy alters the relationship between circulating parathyroid hormone values and bone turnover."

One author reported receiving honoraria from pharmaceutical and biotechnology companies.

Abstract
Full Text (subscription or payment may be required)

Health News Copyright © 2013 HealthDay. All rights reserved.


Previous: Novel Digital Stethoscope Detects Coronary Artery Disease Next: Coal-Tar-Sealed Pavement-Tied PAH Exposure Ups Cancer Risk

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.