Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Cardiology | Family Medicine | Internal Medicine | Pulmonology | Journal

Back to Journal Articles

Biomarker Predicts Outcomes in Pulmonary Hypertension

Last Updated: April 02, 2009.

 

Levels of C-reactive protein predict disease severity and survival

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
High blood levels of a marker of inflammation and tissue damage, C-reactive protein, are associated with disease severity and survival in patients with pulmonary arterial hypertension, according to a report in the April 7 issue of the Journal of the American College of Cardiology.

THURSDAY, April 2 (HealthDay News) -- High blood levels of a marker of inflammation and tissue damage, C-reactive protein (CRP), are associated with disease severity and survival in patients with pulmonary arterial hypertension (PAH), according to a report in the April 7 issue of the Journal of the American College of Cardiology.

Rozenn Quarck, Ph.D., from Katholieke Universiteit Leuven in Belgium, and colleagues compared circulating levels of CRP in 104 patients with PAH, 79 patients with chronic thromboembolic pulmonary hypertension (CTEPH) and 95 healthy subjects.

The researchers found that CRP levels were significantly higher in patients with PAH and CTEPH. In PAH patients, CRP levels correlated with measures of disease severity (New York Heart Association functional class, right atrial pressure, 6-min walking distance) and were significantly higher in non-survivors. PAH patients with CRP levels above 5 mg/L had significantly lower two-year overall and event-free survival, and patients who were able to normalize their CRP levels through medication had significantly better survival. CRP levels did not correlate with disease severity in CTEPH patients, who had significantly reduced levels of CRP after pulmonary endarterectomy, the authors report.

"The present study clearly shows that circulating CRP may predict the severity and the outcome in PAH and that its sensitivity to disease-specific medication may orientate therapeutic options," Quarck and colleagues conclude.

One author disclosed a financial relationship with Actelion, Encysive, Pfizer and LungRx.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.


Previous: Plant's Mechanism of Reducing Liver Fibrosis Identified Next: Exercise Program Appears Helpful in Migraine Patients

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.