Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Family Medicine | Infections | Internal Medicine | Critical Care | Emergency Medicine | Nursing | ENT | Pathology | Pulmonology | Journal

Back to Journal Articles

Moxifloxacin May Accelerate Tuberculosis Cure by Months

Last Updated: April 03, 2009.

 

Brazilian study suggests enhanced treatment can shorten TB cure from six to two months

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
The standard first-line tuberculosis treatment regimen enhanced with the fluoroquinolone moxifloxacin can cure the disease three times faster than standard treatment alone, researchers report in the April 4 issue of The Lancet.

FRIDAY, April 3 (HealthDay News) -- The standard first-line tuberculosis treatment regimen enhanced with the fluoroquinolone moxifloxacin can cure the disease three times faster than standard treatment alone, researchers report in the April 4 issue of The Lancet.

Marcus B. Conde, M.D., of the Instituto de Doencas do Torax/Hospital Clementino Fraga Filho in Rio de Janeiro, Brazil, and colleagues conducted a phase II, double-blind, randomized trial of moxifloxacin in a treatment regimen for sputum smear-positive tuberculosis. The 170 participants all received isoniazid, rifampicin, and pyrazinamide at standard doses and were randomized to additionally receive moxifloxacin (400 mg) with an ethambutol placebo (n=85) or ethambutol (15 to 20 mg/kg) with a moxifloxacin placebo (n=85). Medication was administered five days per week for eight weeks.

Results were assessed at the eight-week endpoint using modified intention-to-treat analysis. Due to culture contamination and other factors, 146 patients (moxifloxacin, n=74; ethambutol, n=72) were included in the final analysis. The researchers found conversion to sputum smear-negative occurred in 59 patients (80 percent) in the moxifloxacin group compared with 45 (63 percent) in the ethambutol group. The authors note that standard treatment alone takes six months to effect a cure.

"The results of our trial have substantial implications for future trials. First, the improved culture conversion rates found after eight weeks in the experimental group suggest that moxifloxacin, in combination with other first-line antituberculosis drugs, could shorten the time needed to cure tuberculosis by several months," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.


Previous: Physician Roles Unclear in Cancer Survivor Care Next: Rare Pregnancy Blood Disorders Can Elude Diagnosis

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.