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Abdominal Obesity Predicts Death in Kidney Failure

Last Updated: April 09, 2009.

Measures of abdominal obesity such as waist circumference and waist-to-hip ratio are associated with a higher risk of death in patients with end-stage renal disease, according to a report in the April 14 issue of the Journal of the American College of Cardiology.

THURSDAY, April 9 (HealthDay News) -- Measures of abdominal obesity such as waist circumference and waist-to-hip ratio are associated with a higher risk of death in patients with end-stage renal disease, according to a report in the April 14 issue of the Journal of the American College of Cardiology.

Maurizio Postorino, M.D., from CNR-IBIM in Reggio Calabria, Italy, and colleagues examined the association between measures of abdominal obesity (waist circumference and waist/hip ratio), body mass index (BMI), and mortality in 537 patients with end-stage renal disease.

The researchers found that after adjusting for cardiovascular risk factors, the risk of all-cause mortality was predicted by waist circumference (hazard ratio 1.23 for each 10-cm increase), waist/hip ratio (hazard ratio 1.24 for each 0.1 increase), and BMI (hazard ratio 0.89 per 1 kg/m2 increase). The risk of cardiovascular mortality was also predicted by waist circumference (hazard ratio 1.37 for each 10-cm increase), waist/hip ratio (hazard ratio 1.21 for each 0.1 increase), and BMI (hazard ratio 0.86 per 1 kg/m2 increase), the authors report.

"Abdominal obesity underlies a high risk of all-cause and cardiovascular mortality in patients with end-stage renal disease," Postorino and colleagues conclude. "Redefinition of nutritional status by combining the metrics of abdominal obesity and BMI may refine prognosis in the end-stage renal disease population."

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