Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Endocrinology | Family Medicine | Gynecology | Internal Medicine | Nursing | Oncology | Orthopedics | ENT | Pathology | Rheumatology | Journal

Back to Journal Articles

Oral Bisphosphonates Link to Esophageal Cancer Analyzed

Last Updated: April 22, 2009.

 

Studies reported in NEJM correspondence find no cancer risk with osteoporosis drug

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Oral bisphosphonate does not appear to increase risk for esophageal cancer, according to analyses of Danish and U.S. data reported by separate researchers in the April 23 issue of the New England Journal of Medicine.

WEDNESDAY, April 22 (HealthDay News) -- Oral bisphosphonate does not appear to increase risk for esophageal cancer, according to analyses of Danish and U.S. data reported by separate researchers in the April 23 issue of the New England Journal of Medicine.

In one study, Bo Abrahamsen, M.D., of Copenhagen University Hospital Gentofte in Hellerup, Denmark, and colleagues compared national registry data for 13,678 osteoporosis patients on oral bisphosphonates with 27,356 patients not on bisphosphonates. The researchers followed the patients for a median of 2.2 years and identified 37 cases of esophageal cancer and 48 cases of gastric cancer. Hazard ratios for the bisphosphonate patients compared to the non-bisphosphonate patients were 0.78 for the combined cancers, 0.35 for esophageal cancer only, and 1.23 for gastric cancer only.

In the other study, Daniel H. Solomon, M.D., of Brigham and Women's Hospital in Boston, and colleagues compared esophageal cancer rates among osteoporosis patients on oral bisphosphonates and those on other osteoporosis medications with incidence estimates from Surveillance, Epidemiology, and End Results (SEER) data. The esophageal cancer incident rates per 100,000 patients were 26.7 for patients on bisphosphonates, 48.4 for patients on other medications, and 23.7 for SEER registrants.

"In standardized analyses, we found no increase in the incidence rate of esophageal cancer among persons who received oral bisphosphonates as compared with persons who received other osteoporosis medications and as compared with SEER estimates," Solomon and colleagues write.

Authors of the first study disclosed financial relationships with various pharmaceutical companies; authors of the second disclosed grant support from Amgen.

Extract
Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.


Previous: Stretches Without Health Insurance More Common Next: Parents Need More Education About Child's Cardiac Surgery

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.