THURSDAY, May 7 (HealthDay News) -- Compounds in soy and red wine may positively affect gynecologic health and help prevent endometriosis, according to a prize-winning paper presented this week at the American College of Obstetricians and Gynecologists' Annual Clinical Meeting, held from May 2 to 6 in Chicago.
Sharai C. Amaya, M.D., of the Greenville Hospital System in South Carolina, and colleagues studied the effects of geninstein and resveratrol on endometrial proliferation and activation in the cell line ECC-1 and in immunocompromised mice which had been implanted with human endometrium or endometriosis.
Both studies showed that geninstein and resveratrol had anti-estrogenic activity. In mice treated with estradiol and progesterone, the researchers found that geninstein and resveratrol reduced the size and activity of implanted endometrial tissue but that only the highest dose of resveratrol was associated with a statistically significant effect on cell proliferation.
"Resveratrol may be functioning as an aryl hydrocarbon receptor antagonist. Further studies are required in humans to investigate the role of dietary compounds such as soy (geninstein) or red wine (resveratrol) on both gynecologic health and disease," the authors conclude.
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