Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Cardiology | Family Medicine | Internal Medicine | Critical Care | Emergency Medicine | Neurology | Nursing | Journal

Back to Journal Articles

Window for Stroke Treatment Opened to 4.5 Hours

Last Updated: May 29, 2009.

 

Treatment window for rtPA expanded for some stroke patients but confirmation with further analyses urged

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
The clot-busting drug recombinant tissue plasminogen activator can be given to eligible stroke victims as long as 4.5 hours after onset of symptoms, according to a new scientific advisory published online May 28 in Stroke: Journal of the American Heart Association.

FRIDAY, May 29 (HealthDay News) -- The clot-busting drug recombinant tissue plasminogen activator (rtPA) can be given to eligible stroke victims as long as 4.5 hours after onset of symptoms, according to a new scientific advisory published online May 28 in Stroke: Journal of the American Heart Association, but the American Heart Association (AHA)/American Stroke Association (ASA) still urge further analyses.

Gregory J. del Zoppo, M.D., chair of the AHA/ASA advisory writing committee, and colleagues based the new rtPA guideline on results from the 2008 European Cooperative Acute Stroke Study-3 (ECASS-3), a multicenter, randomized trial in which some patients were treated successfully with rtPA up to 4.5 hours after stroke onset.

The authors note that eligibility criteria for rtPA treatment within 4.5 hours is similar to three-hour criteria. However, some patients suitable for treatment within three hours should not be treated during the expanded treatment window, including those older than 80, suffering a severe stroke, with a history of stroke and diabetes, or taking oral anticoagulants with an international normalized ratio of 1.7 at most.

"The ECASS-3 trial represents an important advance in the treatment of acute ischemic stroke. The results, which are consistent with the results in this time window from previous studies and pooled analyses of previous trials, provide level B evidence that intravenous rtPA can be given safely to carefully selected patients treated three to 4.5 hours after stroke and that intravenous rtPA given in this time period can improve outcomes after stroke in a selected group of patients," the authors write.

Some members of the writing committee reported financial relationships with the pharmaceutical industry.

Abstract
Full Text

Copyright © 2009 ScoutNews, LLC. All rights reserved.


Previous: ACSM: Yoga Can Benefit Patients With Asthma Next: Links Between Bleeding, PCI, Mortality Explored

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.