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Category: Endocrinology | Monthly Briefing

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June 2009 Briefing - Diabetes & Endocrinology

Last Updated: July 01, 2009.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for June 2009. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Childhood Leukemia May Increase Insulin Resistance

TUESDAY, June 30 (HealthDay News) -- Survivors of childhood acute lymphoblastic leukemia are at increased risk of insulin resistance in adulthood compared to their peers, according to a study published online June 29 in the Journal of Clinical Oncology.

Abstract
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Hypoglycemia Serious Concern for Hospitalized Diabetics

MONDAY, June 29 (HealthDay News) -- Hospitalized diabetics with hypoglycemia have an increased risk of longer stays, inpatient death, and one-year mortality, according to a study published in the July issue of Diabetes Care.

Abstract
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Plasma Enzyme Essential for Successful Reproduction

MONDAY, June 29 (HealthDay News) -- The plasma enzyme phospholipase C-β1 may be essential for reproduction, according to a study published in the July issue of Endocrinology.

Abstract
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Helicobacter Infection Plays Role in Stomach Cancer

MONDAY, June 29 (HealthDay News) -- The effects of Helicobacter felis infection on the expression of the hormone gastrin can lead to the development of cancer in mice, with tumors developing at different sites in the stomach depending on the mouse's native gastrin level, according to a study reported in the July issue of the American Journal of Pathology.

Abstract
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Hormone Effects on Hepatic Lipogenesis Studied

FRIDAY, June 26 (HealthDay News) -- Thyroid hormone regulates carbohydrate response element-binding protein and sterol response element-binding protein genes reciprocally, according to a study published in the July issue of Endocrinology.

Abstract
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DHA, EPA, Low Glycemic Index Help in Macular Degeneration

THURSDAY, June 25 (HealthDay News) -- Diets that contain more omega-3 fatty acids and have a lower glycemic index may help prevent progression to advanced age-related macular degeneration (AMD), according to research published online June 12 in the British Journal of Ophthalmology.

Abstract
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Americans Paying for More of Their Health Care Costs

WEDNESDAY, June 24 (HealthDay News) -- Out-of-pocket costs are rising for Americans with health care coverage, including premiums, deductibles and copayments, according to a new June 23 report from the U.S. Department of Health & Human Services.

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Bariatric Surgery Trims Cancer Incidence in Obese Women

WEDNESDAY, June 24 (HealthDay News) -- Weight loss resulting from bariatric surgery can cut cancer incidence in obese women, but has no significant effect in obese men, according to a study published online June 24 in The Lancet Oncology.

Abstract
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Monitoring May Be Unnecessary After Bisphosphonate Treatment

WEDNESDAY, June 24 (HealthDay News) -- Postmenopausal women treated with a potent bisphosphonate should not undergo bone mineral density monitoring within the first three years of starting treatment because such tests can give misleading results, according to a study published online on June 23 in BMJ.

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Elements of Mediterranean Diet Add Up to Lower Mortality

WEDNESDAY, June 24 (HealthDay News) -- Different elements of the Mediterranean diet contribute to its beneficial effect on overall mortality, according to a study published online on June 23 in BMJ.

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Secondary Causes for Low Bone Mineral Density Common

TUESDAY, June 23 (HealthDay News) -- Many postmenopausal breast cancer survivors may have secondary causes of low bone mineral density that are potentially treatable, according to research published online on June 22 in the Journal of Clinical Oncology.

Abstract
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High Hemoglobin Targets Not Helpful to Kidney Patients

TUESDAY, June 23 (HealthDay News) -- Aiming for a high hemoglobin target when treating chronic kidney disease patients for anemia is not more beneficial than targeting a lower level, according to a study published in the June 22 issue of the Archives of Internal Medicine, while a second study in the same issue found that chronic kidney disease patients are at increased risk of hyperkalemia.

Abstract - Clement
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Abstract - Einhorn
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Editorial (subscription or payment may be required)

President Signs Tobacco Law, Acts on Medicare Coverage

MONDAY, June 22 (HealthDay News) -- President Barack Obama moved on two health care fronts today, signing new legislation to regulate tobacco industry marketing and announcing an agreement with the nation's pharmaceutical companies to reduce the cost of prescription drugs for Americans on Medicare who find themselves in the so-called "doughnut hole" coverage gap.

Family Smoking Prevention and Tobacco Control Act
Pharmaceutical Discounts for Seniors

Urinary Symptoms Linked to Metabolic Syndrome in Men

MONDAY, June 22 (HealthDay News) -- In men, there is a significant association between lower urinary tract symptoms and metabolic syndrome, according to a study published online June 18 in the Journal of Urology.

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Treatment May Protect Against Diet-Related Obesity

MONDAY, June 22 (HealthDay News) -- Angiotensin-converting enzyme (ACE) inhibition led to less gain of body weight and fat mass, as well as improved glucose tolerance in rats, according to research published online June 4 in Endocrinology.

Abstract
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Reinforced Infection Control Needed to Combat H1N1

MONDAY, June 22 (HealthDay News) -- Infection control messages aimed at health care workers should be reinforced in an effort to reduce the spread of novel influenza A (H1N1) virus, according to a study published in the June 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Ethnic Variation of Diabetes Prevalence Studied

FRIDAY, June 19 (HealthDay News) -- A number of racial and ethnic groups showed a higher diabetes prevalence compared with Caucasians, even among those who were not overweight or obese, according to research published in a 2009 Ethnicity & Disease.

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Half of Seniors on Kidney Transplant List May Die

FRIDAY, June 19 (HealthDay News) -- Nearly half of the patients older than 60 waiting for a kidney transplant from a deceased donor will die while on the waiting list, according to a study published online June 18 in the Clinical Journal of the American Society of Nephrology.

Abstract
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Incontinence Common in Women With Type 1 Diabetes

FRIDAY, June 19 (HealthDay News) -- Urinary tract infections (UTIs) and increased weight are associated with higher risk of urinary incontinence in women with type 1 diabetes, according to research published in the June issue of Urology.

Abstract
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Purpose in Life Affects Mortality Rates in Older Adults

THURSDAY, June 18 (HealthDay News) -- Older adults who score highly on purpose-in-life scales have lower risk of mortality than their counterparts with low scores, according to a study published in the June issue of Psychosomatic Medicine.

Abstract
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Individual Mandate for Health Insurance Affordable and Fair

WEDNESDAY, June 17 (HealthDay News) -- Reforming the health insurance market so that all individuals are required to obtain at least a minimum amount of health insurance would eliminate the problem of adverse selection that the current system enables insurers to avoid, according to a perspective published online June 17 in the New England Journal of Medicine.

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Mutation Linked to Hypogonadism in Siblings

WEDNESDAY, June 17 (HealthDay News) -- A mutation in the GNRH1 gene was found in a teenage brother and sister with normosmic idiopathic hypogonadotropic hypogonadism (IHH), which was transmitted as an autosomal recessive trait, according to a report published online June 17 in the New England Journal of Medicine.

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Calcium Supplements Ineffective in Weight Control

WEDNESDAY, June 17 (HealthDay News) -- Diet supplementation with calcium has no effect on total weight, body mass index (BMI), or body fat mass in overweight and obese people, according to a study from the National Institutes of Health reported in the June 16 issue of the Annals of Internal Medicine.

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Spinal Approaches Linked to Similar Pain Outcomes

WEDNESDAY, June 16 (HealthDay News) -- In older patients with osteoporotic vertebral fractures, conservative treatment may be associated with similar improvements in pain as percutaneous vertebroplasty, according to research published in the June 1 issue of Spine.

Abstract
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Severely Obese Patients Need Careful Pre-Op Evaluation

TUSEDAY, June 16 (HealthDay News) -- Given the growing prevalence of severe obesity in the United States, health care professionals should be aware of the special considerations regarding preoperative cardiovascular assessment and perioperative cardiopulmonary management of such patients, according to an advisory published online June 15 in Circulation.

Abstract
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α-Cobratoxin May Be Treatment for Lung Cancer

MONDAY, June 15 (HealthDay News) -- In a mouse model of advanced non-small cell lung cancer, treatment with the nicotinic acetylcholine receptor antagonist α-cobratoxin (α-CbT) was associated with improved survival, according to research published in the June 15 issue of the American Journal of Respiratory and Critical Care Medicine.

Abstract
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Editorial (subscription or payment may be required)

Sweeping Medical Reforms Lack Medical Liability Element

MONDAY, June 15 (HealthDay News) -- Three approaches to medical reform currently under discussion in the United States all have pros and cons, and questions remain over whether or not the reform package should include changes to the medical liability system, according to an article published online June 15 in the New England Journal of Medicine.

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Bill Giving FDA Authority Over Tobacco on Way to President

FRIDAY, June 12 (HealthDay News) -- Legislation giving the U.S. Food and Drug Administration (FDA) regulatory control over tobacco products is headed to the White House for President Obama's signature, as health organizations continue to applaud the action.

AMA Press Release
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Senate Approves Bill Giving FDA Authority Over Tobacco

THURSDAY, June 11 (HealthDay News) -- The U.S. Senate has passed a measure that would give the U.S. Food and Drug Administration (FDA) broad authority over the advertising, sale, and manufacture of tobacco products, an action that is being applauded by the American Medical Association, among others.

AMA Press Release
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High-Glycemic Foods Linked to Endothelial Dysfunction

THURSDAY, June 11 (HealthDay News) -- High-glycemic carbohydrates may be linked to reduced flow-mediated dilation in overweight individuals, perhaps pointing to a connection between such foods and cardiovascular disease risk, according to research published in the June 16 issue of the Journal of the American College of Cardiology.

Abstract
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Androgen Deprivation Linked to Diabetes in Prostate Cancer

WEDNESDAY, June 10 (HealthDay News) -- Researchers have found that androgen deprivation therapy (ADT) is associated with a higher risk of diabetes and fragility fractures in men with prostate cancer, according to a study published online June 8 in the Journal of Clinical Oncology. In a related study in the same issue, pretreatment prostate specific antigen (PSA) dynamics do not add predictive value for prostate cancer outcomes.

Abstract - Alibhai
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Editorial
Abstract - O'Brien
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Standard Heart Risk Factors Predict Lifetime Outcomes

TUESDAY, June 9 (HealthDay News) -- Standard risk factors remain strong predictors of left ventricular mass and cardiovascular disease over the adult life course, according to two studies published online June 8 in Circulation.

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Science Advisory Issued on Risks of Overweight

TUESDAY, June 9 (HealthDay News) -- Studies suggesting that total mortality risk is lowest in overweight people need to be placed in a broader context because of the substantial risks associated with excess weight, according to a Science Advisory from the American Heart Association published online June 8 in Circulation.

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Plant-Based Diet Helps Lower Cholesterol

TUESDAY, June 9 (HealthDay News) -- The so-called 'Eco-Atkins' low-carbohydrate, plant-based diet, produces better lipid-lowering results than conventional high-carbohydrate, low-fat diets used for weight loss, according to a study published in the June 8 issue of the Archives of Internal Medicine.

Abstract
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Editorial (subscription or payment may be required)

Guidelines Issued for Exercise Training for Diabetics

TUESDAY, June 9 (HealthDay News) -- In patients with type 2 diabetes, exercise is essential because it significantly reduces cardiovascular risks, according to an American Heart Association Scientific Statement published online June 8 in Circulation.

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Children's Insulin Resistance May Begin During Pregnancy

MONDAY, June 8 (HealthDay News) -- The fetuses of obese mothers may develop insulin resistance in utero, according to research published in the June issue of Diabetes Care.

Abstract
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Signaling Network Identified in Prostatic Hyperplasia Model

FRIDAY, June 5 (HealthDay News) -- Analysis of a rat model of benign prostatic hyperplasia (BPH) has identified a cellular signaling network and targets that could be exploited for therapeutics, according to a study published online May 14 in Endocrinology.

Abstract
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Mice Lacking Inflammatory Receptors Prone to Obesity

FRIDAY, June 5 (HealthDay News) -- Mice lacking receptors for a major inflammatory cytokine that is a major inhibitor of insulin sensitivity, tumor necrosis factor, still become obese after being fed a high-fat and high-sugar diet, but are not protected against obesity-associated insulin resistance, according to a study published online May 28 in Endocrinology.

Abstract
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Anti-Thyroid Drug Carries Risk of Liver Injury

THURSDAY, June 4 (HealthDay News) -- The U.S. Food and Drug Administration (FDA) has issued a warning about the risk of serious liver injury as a result of treating Graves' disease with the anti-thyroid drug propylthiouracil (PTU) after adverse reports concerning the drug were reported.

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Many U.K. Trained Doctors Stay in National Health Service

WEDNESDAY, June 3 (HealthDay News) -- The majority of domestic medical students in Britain work in the National Health Service (NHS) after graduation, as do the majority of doctors from overseas who go to the country for training, with men and women choosing similar career paths, according to a study published online June 3 in BMJ.

Abstract
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Common Medical Data, Family History Can Predict Diabetes

WEDNESDAY, June 3 (HealthDay News) -- Commonly available anthropometric data and family history can be used in a simple algorithm to predict who will develop diabetes later in life, according to a study in the June 2 Annals of Internal Medicine.

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Editorial (subscription or payment may be required)

Cardiovascular Issues in Chronic Kidney Disease Reviewed

WEDNESDAY, June 3 (HealthDay News) -- Chronic kidney disease (CKD) raises the risk of cardiovascular problems and can lead to complications following revascularization procedures, according to a review published in the June 9 issue of the Journal of the American College of Cardiology, and greater understanding of the mechanisms involved could lead to improved treatment.

Abstract
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Early Infant Weight Gain Linked to Adult Problems

TUESDAY, June 2 (HealthDay News) -- Rapid weight gain in the first three months of life is associated with development of cardiovascular disease and type 2 diabetes in adulthood, according to a report in the June 3 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)
Special Communication (subscription or payment may be required)

Rosiglitazone Has Modest Effect on Vascular Measure

MONDAY, June 1 (HealthDay News) -- Rosiglitazone may inhibit the progression of vascular disease in individuals with pre-diabetes, according to research published in the June 2 issue of the Journal of the American College of Cardiology.

Abstract
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Editorial

Adults in the United States Living a Less Healthy Lifestyle

MONDAY, June 1 (HealthDay News) -- Middle-aged and elderly adults in the United States have been living a less healthy lifestyle over the last 18 years, according to a study in the June issue of the American Journal of Medicine.

Abstract
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Perceptions of Junk Food TV Ads Aimed at Kids Challenged

MONDAY, June 1 (HealthDay News) -- Television advertisements of particular appeal to children are no more likely to be promoting unhealthy foods than those that don't appeal to children, according to a study published online May 28 in the Archives of Disease in Childhood.

Abstract
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