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Category: Gastroenterology | Monthly Briefing

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June 2009 Briefing - Gastroenterology

Last Updated: July 01, 2009.

 

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Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for June 2009. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Oncology Best Supportive Care Studies Faulted

TUESDAY, June 30 (HealthDay News) -- In oncology, best supportive care studies exhibit ethical and methodological shortcomings, and systematic bias or error that may be due to ad hoc supportive care and lack of standardized delivery, according to a study published online June 29 in the Journal of Clinical Oncology.

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Intense Surveillance Beneficial in Early-Stage Colon Cancer

TUESDAY, June 30 (HealthDay News) -- In patients with stage I and IIA colon cancer, intensive postoperative surveillance is as beneficial as it is in late-stage patients, according to a study published online June 29 in the Journal of Clinical Oncology.

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Colorectal Cancer Risk Elevated in Men and Smokers

MONDAY, June 29 (HealthDay News) -- Male gender and current smoking are significant risk factors for advanced colorectal neoplasia and colorectal cancer, according to two studies published in the June issue of Clinical Gastroenterology and Hepatology.

Abstract - Tsoi
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Abstract - Nguyen
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Helicobacter Infection Plays Role in Stomach Cancer

MONDAY, June 29 (HealthDay News) -- The effects of Helicobacter felis infection on the expression of the hormone gastrin can lead to the development of cancer in mice, with tumors developing at different sites in the stomach depending on the mouse's native gastrin level, according to a study reported in the July issue of the American Journal of Pathology.

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Body Mass Index Affects Bowel Preparation for Colonoscopy

FRIDAY, June 26 (HealthDay News) -- Overweight and obese patients are more likely than normal-weight patients to have inadequate bowel preparation prior to colonoscopy, which could result in missed mucosal lesions and the need for early repeat colonoscopy, according to a study published in the June issue of Clinical Gastroenterology and Hepatology.

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Seattle Protocol No Better Than Less Intensive Method

FRIDAY, June 26 (HealthDay News) -- In Barrett's esophagus patients with high-grade dysplasia, the intense Seattle biopsy protocol is no more reliable than a less intensive surveillance protocol at predicting early cancers at the time of esophagectomy, according to a study in the June Clinical Gastroenterology and Hepatology.

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Alcohol Causes Most Deaths in Russian Adults Under 55

FRIDAY, June 26 (HealthDay News) -- In many years, alcohol causes more than half of all deaths in the 15 to 54 years age group in Russia, and together with smoking accounts for the large discrepancy in adult mortality between western European countries and Russia, according to a study in the June 27 The Lancet, which has a special focus on alcohol.

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Editorial (subscription or payment may be required)

Genetic Variations Affect Response to Celecoxib

THURSDAY, June 25 (HealthDay News) -- Variations in the cytochrome P450 2C9 (CYP2C9) gene may affect patient response to celecoxib in the prevention of colorectal adenomas, according to a study published in the June issue of Gastroenterology.

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Ablative Therapy Cost Effective in Barrett's Esophagus

THURSDAY, June 25 (HealthDay News) -- In patients with Barrett's esophagus, endoscopic ablation is a cost-effective strategy for managing those with high-grade dysplasia, and may also be cost effective for those with low-grade dysplasia or no dysplasia, according to a study published in the June issue of Gastroenterology.

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Depression May Reactivate Inflammatory Bowel Disease

THURSDAY, June 25 (HealthDay News) -- In patients with quiescent inflammatory bowel disease, depression may reactivate inflammation, according to an animal study published in the June issue of Gastroenterology.

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Very Low Carb Diet Can Treat Irritable Bowel Syndrome

THURSDAY, June 25 (HealthDay News) -- Patients with diarrhea-predominant irritable bowel syndrome who adhere to a very low carbohydrate diet experience relief of symptoms and improved quality of life, according to an article published in the June issue of Clinical Gastroenterology and Hepatology.

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Urine Biomarkers Discovered for Acute Appendicitis

WEDNESDAY, June 24 (HealthDay News) -- The presence of certain protein biomarkers in the urine may be useful in the diagnosis of acute appendicitis, which can present with varied symptoms, according to a study reported online June 24 in the Annals of Emergency Medicine.

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Americans Paying for More of Their Health Care Costs

WEDNESDAY, June 24 (HealthDay News) -- Out-of-pocket costs are rising for Americans with health care coverage, including premiums, deductibles and copayments, according to a new June 23 report from the U.S. Department of Health & Human Services.

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Bariatric Surgery Trims Cancer Incidence in Obese Women

WEDNESDAY, June 24 (HealthDay News) -- Weight loss resulting from bariatric surgery can cut cancer incidence in obese women, but has no significant effect in obese men, according to a study published online June 24 in The Lancet Oncology.

Abstract
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Body Mass Index Affects Pancreatic Cancer Risks

TUESDAY, June 23 (HealthDay News) -- Younger adults who are overweight or obese have an increased risk of developing pancreatic cancer and at an earlier age, and older adults who are obese and develop pancreatic cancer have reduced overall survival, according to a study published in the June 24 issue of the Journal of the American Medical Association.

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President Signs Tobacco Law, Acts on Medicare Coverage

MONDAY, June 22 (HealthDay News) -- President Barack Obama moved on two health care fronts today, signing new legislation to regulate tobacco industry marketing and announcing an agreement with the nation's pharmaceutical companies to reduce the cost of prescription drugs for Americans on Medicare who find themselves in the so-called "doughnut hole" coverage gap.

Family Smoking Prevention and Tobacco Control Act
Pharmaceutical Discounts for Seniors

Violet Light Treatment May Be Useful Against H. pylori

MONDAY, June 22 (HealthDay News) -- The use of intra-gastric violet light phototherapy could be helpful in eradicating Helicobacter pylori in infected individuals, according to research published in the July issue of Lasers in Surgery and Medicine.

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Reinforced Infection Control Needed to Combat H1N1

MONDAY, June 22 (HealthDay News) -- Infection control messages aimed at health care workers should be reinforced in an effort to reduce the spread of novel influenza A (H1N1) virus, according to a study published in the June 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Budesonide Found Effective for Lymphocytic Colitis

FRIDAY, June 19 (HealthDay News) -- In patients with lymphocytic colitis, oral budesonide treatment is effective in leading to clinical remission, according to a study published in the June issue of Gastroenterology.

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Treatment With MicroRNA Linked to Liver Cancer Benefit

THURSDAY, June 18 (HealthDay News) -- The systemic delivery of miR-26a, a microRNA, using adeno-associated virus was associated with protection from hepatocellular carcinoma progression in a mouse model of the disease, according to research published in the June 12 issue of Cell.

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Glove Perforation Raises Odds of Surgical Site Infection

THURSDAY, June 18 (HealthDay News) -- Surgical glove perforation significantly increases the risk of surgical site infection in procedures where surgical antimicrobial prophylaxis is not applied, according to a study published in the June issue of the Archives of Surgery.

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Editorial (subscription or payment may be required)

Individual Mandate for Health Insurance Affordable and Fair

WEDNESDAY, June 17 (HealthDay News) -- Reforming the health insurance market so that all individuals are required to obtain at least a minimum amount of health insurance would eliminate the problem of adverse selection that the current system enables insurers to avoid, according to a perspective published online June 17 in the New England Journal of Medicine.

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Colonography May Benefit High-Risk Patients

TUESDAY, June 16 (HealthDay News) -- In patients with an elevated risk of colorectal cancer, computed tomographic (CT) colonography may be a feasible alternative to colonoscopy, according to a study in the June 17 Journal of the American Medical Association.

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Adverse Events for Colonoscopy Increase With Age in Elderly

TUESDAY, June 16 (HealthDay News) -- While the risk of adverse events from colonoscopy in elderly patients is low, it increases with age and comorbid conditions and should be a factor in a physician's decision to recommend the procedure, according to a study in the June 16 Annals of Internal Medicine.

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Racial Clustering Linked With Access to Colon Cancer Care

TUESDAY, June 16 (HealthDay News) -- The more African Americans a county has, the less colorectal surgeons, gastroenterologists and radiation oncologists there are in that county, whereas an increasing percentage of Asian Americans is associated with more specialists in that area, according to a study published in the June issue of the Archives of Surgery.

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Bariatric Surgery May Lead to Back Pain Improvements

MONDAY, June 15 (HealthDay News) -- The substantial weight loss resulting from bariatric surgery may be associated with moderate improvements in pre-existing low back pain in the following year, according to research published in the June issue of The Spine Journal.

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Sweeping Medical Reforms Lack Medical Liability Element

MONDAY, June 15 (HealthDay News) -- Three approaches to medical reform currently under discussion in the United States all have pros and cons, and questions remain over whether or not the reform package should include changes to the medical liability system, according to an article published online June 15 in the New England Journal of Medicine.

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Bill Giving FDA Authority Over Tobacco on Way to President

FRIDAY, June 12 (HealthDay News) -- Legislation giving the U.S. Food and Drug Administration (FDA) regulatory control over tobacco products is headed to the White House for President Obama's signature, as health organizations continue to applaud the action.

AMA Press Release
More Information

Gut Permeability Linked to Fatty Liver Disease

FRIDAY, June 12 (HealthDay News) -- Patients with non-alcoholic fatty liver disease (NAFLD) may have greater intestinal permeability and a higher likelihood of small intestinal bacterial overgrowth, which correlate with steatosis severity, according to research published in the June issue of Hepatology.

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Senate Approves Bill Giving FDA Authority Over Tobacco

THURSDAY, June 11 (HealthDay News) -- The U.S. Senate has passed a measure that would give the U.S. Food and Drug Administration (FDA) broad authority over the advertising, sale, and manufacture of tobacco products, an action that is being applauded by the American Medical Association, among others.

AMA Press Release
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Colorectal Cancer Rates Increasing in Younger Adults

THURSDAY, June 11 (HealthDay News) -- Though overall rates of colorectal cancer have been declining in the United States, incidence rates in adults under 50 years of age have been increasing since the early 1990s, according to research published in the June issue of Cancer Epidemiology Biomarkers & Prevention.

Abstract
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Higher Donor Risk Index Linked to Liver Graft Failure

THURSDAY, June 11 (HealthDay News) -- The donor risk index appears to have a particularly adverse effect on outcomes in liver transplant recipients with hepatitis C virus (HCV), but liver grafts with steatosis don't seem to worsen three-year survival in patients with this infection, according to the results of two studies published in the June issue of Liver Transplantation.

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Acupuncture Can Alleviate Dyspepsia in Pregnancy

WEDNESDAY, June 10 (HealthDay News) -- Acupuncture may help pregnant women who experience dyspepsia by alleviating their symptoms and reducing the need for medication, according to a study published in the June issue of Acupuncture in Medicine.

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Very Heavy Drinking Risk Factor for Chronic Pancreatitis

TUESDAY, June 9 (HealthDay News) -- Although alcohol and tobacco consumption are risk factors for chronic and recurrent acute pancreatitis, only a minority of patients are heavy drinkers, according to a study published in the June 8 issue of the Archives of Internal Medicine.

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Synthetic Interferon May Be Useful for Hep C Retreatment

MONDAY, June 8 (HealthDay News) -- Daily treatment with consensus interferon (CIFN) and ribavirin (RBV) may be beneficial in patients with hepatitis C who failed with other treatment, according to research published in the June issue of Hepatology.

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EGCG Treatment May Be Useful for Chronic Leukemia

FRIDAY, June 5 (HealthDay News) -- An oral preparation of epigallocatechin-3-gallate (EGCG) with Polyphenon E appeared to be well tolerated and provided clinical activity in patients with chronic lymphocytic leukemia (CLL), according to research published online May 26 in the Journal of Clinical Oncology.

Abstract
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Genetic Abnormalities Test Detects Intestinal Cancers

FRIDAY, June 5 (HealthDay News) -- A fluorescent technique to detect chromosomal abnormalities is more sensitive than routine cytology for the detection of suspected gastrointestinal cancer while maintaining a high specificity, according to a study in the June issue of Gastroenterology.

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Anti-Thyroid Drug Carries Risk of Liver Injury

THURSDAY, June 4 (HealthDay News) -- The U.S. Food and Drug Administration (FDA) has issued a warning about the risk of serious liver injury as a result of treating Graves' disease with the anti-thyroid drug propylthiouracil (PTU) after adverse reports concerning the drug were reported.

More Information

Many U.K. Trained Doctors Stay in National Health Service

WEDNESDAY, June 3 (HealthDay News) -- The majority of domestic medical students in Britain work in the National Health Service (NHS) after graduation, as do the majority of doctors from overseas who go to the country for training, with men and women choosing similar career paths, according to a study published online June 3 in BMJ.

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Rotavirus Vaccine Studied in Nicaraguan Children

WEDNESDAY, June 3 (HealthDay News) -- The pentavalent rotavirus vaccine (RV5) is effective in preventing severe rotavirus diarrhea in Nicaraguan children, though to a lesser extent compared with previous trials conducted in developed countries, according to a study in the June 3 issue of the Journal of the American Medical Association.

Abstract
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Colon Cancer Screening Program Benefits Unclear

MONDAY, June 1 (HealthDay News) -- There was no reduction in incidence of colon cancer after seven years' follow-up on a screening program in Norway, and it is too early to say whether such programs can produce concrete benefits, according to a study published online on May 31 in BMJ.

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