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Category: Nephrology | Monthly Briefing

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July 2009 Briefing - Nephrology

Last Updated: August 03, 2009.

 

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Here are what the editors at HealthDay consider to be the most important developments in Nephrology for July 2009. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Gender Outcomes in Kidney Transplants Examined

FRIDAY, July 31 (HealthDay News) -- Women who undergo kidney transplant from a male donor have a 12 percent higher risk of graft failure than all other gender combinations, but at the 10-year point the risk is the same, according to a study published online June 18 in the Journal of the American Society of Nephrology.

Abstract
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Electronic Disease Surveillance Systems Vary Widely

FRIDAY, July 31 (HealthDay News) -- Electronic disease surveillance systems vary widely from state to state and the lack of homogeneity will raise the cost of data sharing, according to a study published in the July 31 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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U.S. Health Data Network a Powerful Tool for Quality

FRIDAY, July 31 (HealthDay News) -- The U.S. health care system is on the verge of a new era in which distributed health data networks will assure local control of sensitive individual patient data, while providing medical researchers and policy makers access to powerful aggregate data on millions of patients, according to a pair of articles in the September 1 issue of the Annals of Internal Medicine.

Abstract - Maro
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Abstract - Pace
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Kt/V Use in Predicting Mortality Affected by Model

FRIDAY, July 31 (HealthDay News) -- In dialysis patients, Kt/V significantly predicts mortality when accelerated failure time models are used, but not proportional hazard models, according to research published online July 30 in the Journal of the American Society of Nephrology.

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Patient Characteristics Poor Predictors of Heart Biomarker

THURSDAY, July 30 (HealthDay News) -- Patient demographics and clinical characteristics are poor predictors of having C-reactive protein (CRP) levels high enough to benefit from statin treatment, according to a study in the August 1 issue of the American Journal of Cardiology.

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Pregnant Women, Children Among H1N1 Vaccine Priorities

WEDNESDAY, July 29 (HealthDay News) -- Pregnant women, health care workers, and children who are aged 6 months and older should be the first to receive this fall's H1N1 swine flu vaccine, according to recommendations made July 29 by a U.S. Centers for Disease Control and Prevention (CDC) panel.

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Type 1 Diabetes Complications Becoming Less Common

WEDNESDAY, July 29 (HealthDay News) -- Intensive therapy to treat type 1 diabetes mellitus reduces the frequency of serious complications over the long term, according to a study published in the July 27 issue of the Archives of Internal Medicine.

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Drug Can Improve Cardiac Markers in Kidney Disease

TUESDAY, July 28 (HealthDay News) -- In patients with early-stage chronic kidney disease and good blood pressure control, the addition of spironolactone to treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers can improve markers of cardiovascular disease, according to a study in the August 4 issue of the Journal of the American College of Cardiology.

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Editorial (subscription or payment may be required)

New Guidelines Developed for Pediatric Nephrotic Syndrome

MONDAY, July 27 (HealthDay News) -- New guidelines provide recommendations for the management of pediatric nephrotic syndrome, one of the more common childhood kidney diseases, according to a systematic review in the August issue of Pediatrics.

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Methods to Determine Health Care Priorities Questioned

FRIDAY, July 23 (HealthDay News) -- Evaluating health care priorities based on the attitudes of patients (direct method) or the attitudes of the general public (indirect method) can produce different results, complicating decisions on the allocation of health care resources, according to two papers published July 22 in BMJ.

Abstract - Arnold
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Abstract - Dolan
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Camera Phones Can Help Doctors Make Rare Diagnoses

FRIDAY, July 24 (HealthDay News) -- A pregnant patient with an uncommon nipple condition captured images of the transient changes to her nipples and gave them to her doctor, enabling an accurate diagnosis, according to an article published online July 22 in BMJ.

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'Enhanced' Meat High in Phosphate and Potassium

FRIDAY, July 24 (HealthDay News) -- Uncooked meat and poultry products that have been "enhanced" with additives during processing often have much higher levels of phosphate and potassium compared with their additive-free versions, though the additives may not be listed on the label, according to a study published online July 23 in the Clinical Journal of the American Society of Nephrology.

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Marker of Renal Injury May Aid in Diagnosis

FRIDAY, July 24 (HealthDay News) -- Urinary levels of neutrophil gelatinase-associated lipocalin (NGAL), a marker of renal tubular injury, are higher in patients with HIV-associated nephropathy (HIVAN) and in critically ill patients who develop acute kidney injury, according to two studies published online July 23 in the Journal of the American Society of Nephrology.

Abstract - Paragas
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Abstract - Siew
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Flu Vaccine Effects Uncertain in Immunocompromised

THURSDAY, July 23 (HealthDay News) -- Though roughly 1 percent of the U.S. population is immunocompromised for a variety of reasons, data on the efficacy of influenza vaccines in these individuals are scarce, according to research published in the August issue of The Lancet Infectious Diseases.

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Treatment Reverses Type 1 Diabetes in Mouse Model

FRIDAY, July 17 (HealthDay News) -- In a mouse model of type 1 diabetes, treatment with anti-CD3 antibody and transplantation of pancreatic anlagen resulted in restoration of β-cell function and long-term diabetes recovery, according to research published online July 9 in Endocrinology.

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Obesity Rates Highest Among African-American Population

FRIDAY, July 17 (HealthDay News) -- The prevalence of obesity is far higher among African-Americans than Caucasians in America, and Hispanics also have significantly higher obesity rates, according to a study published in the July 17 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Sunitinib Found Effective, Safe in Advanced Kidney Cancer

FRIDAY, July 17 (HealthDay News) -- In patients with advanced or metastatic renal cell carcinoma with poor prognosis who are not usually entered into clinical trials, sunitinib significantly prolongs progression-free and overall survival and is well-tolerated, according to a study published online July 16 in The Lancet Oncology.

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Reflection & Reaction (subscription or payment may be required)

Bicarbonate May Be Beneficial in Chronic Kidney Disease

FRIDAY, July 17 (HealthDay News) -- In patients with advanced chronic kidney disease, bicarbonate supplementation may slow progression to end-stage renal disease, according to a study published online July 16 in the Journal of the American Society of Nephrology.

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Potassium Citrate May Prevent Stones in Ketogenic Diet

MONDAY, July 13 (HealthDay News) -- An oral potassium citrate supplement, Polycitra K, can prevent the formation of kidney stones in children put on a ketogenic diet for intractable epilepsy, according to a study published online July 13 in Pediatrics.

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Dialysis May Be Resumed Safely After Heart Attack

FRIDAY, July 10 (HealthDay News) -- In patients with end-stage renal disease who have heart attacks, resumption of dialysis has no significant effect on morbidity or mortality, according to a study published online July 9 in the Clinical Journal of the American Society of Nephrology.

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Obesity Rates for American Adults Still Going Up

THURSDAY, July 9 (HealthDay News) -- At least 25 percent of the adult population in 32 states is now obese, and national prevalence of obesity has risen from 25.6 percent in 2007 to 26.1 percent in 2008, according to a July 8 report by the U.S. Centers for Disease Control and Prevention (CDC).

Press Release
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Soldiers in Iraq Have Fewer Urinary Stones Than Expected

FRIDAY, July 3 (HealthDay News) -- Despite the hot climate and risk of dehydration, servicemen and women deployed to Southwest Asia had a lower incidence of urolithiasis than the general U.S. population, according to a survey reported in the July issue of Urology.

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Editorial (subscription or payment may be required)

Mayo Clinic Streamlines Protocol Development

THURSDAY, July 2 (HealthDay News) -- At the Mayo Clinic Cancer Center, a project using focused process engineering has significantly accelerated the development and approval of clinical trials, according to a study published online June 29 in the Journal of Clinical Oncology.

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Bone Loss Process Not Clear in Hypercalciuria, Kidney Stones

THURSDAY, July 2 (HealthDay News) -- Bone loss in patients with hypercalciuria and nephrolithiasis results from a poorly understood breakdown of the body's mineral metabolism involving the kidneys, the intestines and the bones themselves, according to a literature review reported in the July issue of Urology.

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Idiopathic Membranous Nephropathy Antigen Found

WEDNESDAY, July 1 (HealthDay News) -- In patients with idiopathic membranous nephropathy, the M-type phospholipase A2 receptor (PLA2R) is a major target antigen, a finding that may improve diagnosis and treatment, according to a study published in the July 2 issue of the New England Journal of Medicine.

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Editorial (subscription or payment may be required)

Losartan, Enalapril May Not Slow Diabetic Nephropathy

WEDNESDAY, July 1 (HealthDay News) -- Drugs that blockade the renin-angiotensin system may not reduce progression of nephropathy in patients with type 1 diabetes, but they do slow the progression of retinopathy, according to a study published in the July 2 issue of the New England Journal of Medicine.

Abstract
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Editorial (subscription or payment may be required)

Priorities Set for Comparative Effectiveness Research

WEDNESDAY, July 1 (HealthDay News) -- The extent to which large-scale public investment in comparative effectiveness research can achieve its goals of better decision making and improved uptake of new knowledge depends on engaging the medical profession and patients, according to recommendations by the Institute of Medicine published online June 30 in the Annals of Internal Medicine.

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Editorial - Luce
Editorial - Iglehart
Editorial - Conway & Clancy
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