Create Account | Sign In: Author or Forum

News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
Category: Endocrinology | Family Medicine | Hematology | Oncology | Pathology | Pediatrics | Journal

Back to Journal Articles

Study Finds Obesity Impairs Leukemia Treatment Response

Last Updated: September 23, 2009.

Obesity may directly impair the efficacy of leukemia treatment, according to an animal study published online Sept. 22 in Cancer Research.


Animal study shows that fat cells prevent apoptosis induced by the first-line drug vincristine

Share |

Comments: (0)




WEDNESDAY, Sept. 23 (HealthDay News) -- Obesity may directly impair the efficacy of leukemia treatment, according to an animal study published online Sept. 22 in Cancer Research.

James W. Behan, of Childrens Hospital Los Angeles, and colleagues injected obese and control mice with acute lymphoblastic leukemia cells and treated them with either vincristine or vehicle.

Compared to vehicle, the researchers found that vincristine was associated with improved survival independently from obesity. However, they also found that obesity was associated with an impaired response to vincristine. Among treated mice, seven of 12 obese mice developed progressive leukemia compared to only three of 12 control mice, and one obese mouse developed progressive leukemia before receiving the final dose of vincristine.

"Adipocytes prevented chemotherapy-induced apoptosis, and this was associated with increased expression of the two pro-survival signals Bcl-2 and Pim-2," the authors write. "These findings highlight the role of the adipocyte in fostering leukemia chemotherapy resistance, and may help explain the increased leukemia relapse rate in obese children and adults. Given the growing prevalence of obesity worldwide, these effects are likely to have increasing importance to cancer treatment."

Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Previous: Smoking Associated With Lupus Erythematosus Next: Rhinoplasty Patients Typically Want the 'Ideal Nose'

Reader comments on this article are listed below. Review our comments policy.

Submit your opinion:





Remember my personal information

Notify me of follow-up comments?


Useful Sites
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2016
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.