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Category: Family Medicine | Monthly Briefing

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October 2009 Briefing - Family Practice

Last Updated: November 02, 2009.

 

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Here are what the editors at HealthDay consider to be the most important developments in Family Practice for October 2009. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Endorectal Imaging Benefit Seen in Prostate Cancer

FRIDAY, Oct. 30 (HealthDay News) -- Endorectal magnetic resonance (MR) imaging may be useful in categorizing men with stage T1c prostate cancer for proper treatment management, according to research published in the November issue of Radiology.

Abstract
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Uninsured Children May Be More Likely to Die in the Hospital

FRIDAY, Oct. 30 (HealthDay News) -- In-hospital all-cause mortality is higher among uninsured children than among those who have insurance, according to a study published in the October issue of the Journal of Public Health.

Abstract
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Disability Rates Similar in Foreign, Domestic Adoptees

FRIDAY, Oct. 30 (HealthDay News) -- Children adopted from other countries had similar rates of disability as domestically adopted children, though these rates were much higher than in the general population of children, according to research published in the November issue of Pediatrics.

Abstract
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Working After Retirement Associated With Better Health

FRIDAY, Oct. 30 (HealthDay News) -- Retirees who engage in bridge employment tend to have better health than those who cease work completely, according to a study published in the October issue of the Journal of Occupational Health Psychology.

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Self-Reports Underestimate Number of Pregnant Smokers

FRIDAY, Oct. 30 (HealthDay News) -- Relying on women to self-report whether they smoke results in many pregnant smokers going undetected each year, according to a study published online Oct. 29 in BMJ.

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Immobilization After Intrauterine Insemination May Boost Success

FRIDAY, Oct. 30 (HealthDay News) -- A brief period of immobilization after intrauterine insemination improves ongoing pregnancy rates, according to a study published online Oct. 29 in BMJ.

Abstract
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Maternal Ethnicity and Weight Can Affect Pain and Labor

FRIDAY, Oct. 30 (HealthDay News) -- Asian women and heavier women have slower labor and report less pain, but ethnicity and weight do not explain the substantial differences observed between women, according to a study in the November issue of Anesthesiology.

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Swine Flu Radiographic and CT Imaging Patterns Studied

FRIDAY, Oct. 30 (HealthDay News) -- Ground-glass opacities (GGOs) in one or both lungs with consolidation are the most common computed radiographic (CR) and computed tomography (CT) images of patients with swine-origin influenza A (S-OIV), according to a study to be published in the December issue of the American Journal of Roentgenology.

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Tai Chi Can Improve Pain and Function in Knee Arthritis

FRIDAY, Oct. 30 (HealthDay News) -- The ancient Chinese exercise practice Tai Chi can reduce pain, preserve functionality, and improve personal well-being among subjects with knee osteoarthritis, according to a study published online Oct. 29 in Arthritis & Rheumatism.

Abstract
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Study Finds Benefits With Full-Field Digital Mammography

THURSDAY, Oct. 29 (HealthDay News) -- Full-field digital mammography (FFDM), along with computer-aided diagnosis (CAD), may provide improved detection of microcalcifications and ductal carcinoma in situ, according to research published in the November issue of Radiology.

Abstract
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Additional Recommendations for Imaging on the Rise

THURSDAY, Oct. 29 (HealthDay News) -- Recommendations for additional imaging in radiology reports at one institution increased steeply in recent years, and from 1980 to 2006, radiologic and nuclear medicine procedures increased roughly 10-fold and 2.5 fold, respectively, according to two studies the November issue of Radiology.

Abstract - Sistrom
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Abstract - Mettler
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Study Analyzes Role of STAT3 Genetic Variants in Obesity

THURSDAY, Oct. 29 (HealthDay News) -- Intake of dietary saturated fat may exacerbate the effects of certain gene mutations associated with body weight regulation and glucose homeostasis, according to a study in the November issue of the Journal of Nutrition.

Abstract
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Vessel Type Linked to Disease Severity in Prostate Cancer

THURSDAY, Oct. 29 (HealthDay News) -- Men with prostate tumors whose vascular supply consists of vessels with primitive morphology are more likely to develop lethal disease, according to a study published online Oct. 26 in the Journal of Clinical Oncology.

Abstract
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ACE Inhibitors May Negatively Impact CABG Outcomes

THURSDAY, Oct. 29 (HealthDay News) -- The preoperative use of angiotensin-converting enzyme (ACE) inhibitor therapy before coronary artery bypass grafting (CABG) may increase risk of mortality and other adverse outcomes, according to research published in the Nov. 3 Journal of the American College of Cardiology.

Abstract
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Lifestyle Changes Can Reduce Incidence of Diabetes

THURSDAY, Oct. 29 (HealthDay News) -- Lifestyle changes and metformin lead to weight loss and a reduced incidence of diabetes in high-risk individuals that is maintained for 10 years, according to a study published online Oct. 29 in The Lancet.

Abstract
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Prostate-Specific Antigen Velocity Linked to Mortality

THURSDAY, Oct. 29 (HealthDay News) -- Men with unfavorable prostate cancer whose prostate-specific antigen (PSA) levels rapidly increase at recurrence have a higher risk of death, but only if they have no or minimal comorbidities, according to a study published online Oct. 26 in the Journal of Clinical Oncology.

Abstract
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Sex Hormones Link to Diabetes in Older Women Examined

THURSDAY, Oct. 29 (HealthDay News) -- Adiposity and insulin resistance to varying degrees may explain the association of endogenous bioavailable testosterone (T) with type 2 diabetes (T2DM) in postmenopausal women, but these factors do not completely explain the associations of estradiol (E2) and sex hormone binding globulin (SHBG) with the condition, according to the Multi-Ethnic Study of Atherosclerosis published in the November issue of the Journal of Clinical Endocrinology & Metabolism.

Abstract
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HIV Stigma May Still Impact Medical Care Negatively

THURSDAY, Oct. 29 (HealthDay News) -- A stigma felt by HIV/AIDS patients may negatively impact their access to medical care and adherence to antiretroviral therapy (ART), according to a study in the October issue of the Journal of General Internal Medicine.

Abstract
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Pain Among Men and Women War Veterans Evaluated

THURSDAY, Oct. 29 (HealthDay News) -- Among veterans of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF), women have a lower prevalence of overall pain, moderate-severe pain, and persistent pain compared to men, according to a study in the October issue of Pain Medicine.

Abstract
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Vitamin D Deficiency Found Common in American Children

THURSDAY, Oct. 29 (HealthDay News) -- Suboptimal levels of 25-hydroxyvitamin D (25[OH]D) are common in American children, especially non-Hispanic blacks and Mexican-Americans, according to a study in the November issue of Pediatrics.

Abstract
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Overweight Patients May Have Effect on Doctor's Attitude

THURSDAY, Oct. 29 (HealthDay News) -- Physicians have lower respect for patients with high body mass index (BMI), which may have an impact on patient care and outcomes, according to a study published online Sept. 18 in the Journal of General Internal Medicine.

Abstract
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Cognitive Behavioral Therapy Helps Overcome Winter Blues

THURSDAY, Oct. 16 (HealthDay News) -- Patients with seasonal affective disorder who undergo a one-year course of cognitive behavioral therapy, either on its own or in combination with light therapy, are less likely to have a recurrence of winter depression than their counterparts who undergo light therapy alone, according to a study in the September issue of Behavior Therapy.

Abstract
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Male Foreskin Size Can Affect Risk of HIV Infection

THURSDAY, Oct. 29 (HealthDay News) -- Men with larger foreskins are at higher risk of being infected with HIV, according to a study in the Oct. 23 issue of AIDS.

Abstract
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Post-Exposure Prophylaxis of HIV Transmission Spotlighted

WEDNESDAY, Oct. 28 (HealthDay News) -- Patients who have a one-time sexual encounter with a person who is highly likely to be HIV-positive should initiate post-exposure prophylaxis as soon as possible, according to a feature article published in the Oct. 29 issue of the New England Journal of Medicine.

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Antibiotic Prophylaxis May Halt UTI Recurrence in Children

WEDNESDAY, Oct. 28 (HealthDay News) -- In children with recurrent urinary tract infections, low-dose, continuous oral antibiotic therapy may help prevent future recurrences, according to an Australian study in the Oct. 29 issue of the New England Journal of Medicine.

Abstract
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Editorial

Genetic Mutation Linked to Severe Candidasis

WEDNESDAY, Oct. 28 (HealthDay News) -- Impaired dectin-1 signaling may be responsible for severe mucocutaneous fungal infections, according to two reports published in the Oct. 29 issue of the New England Journal of Medicine.

Abstract - Ferwerda
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Abstract - Glocker
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Impact of Childhood Sleep Patterns on Obesity Evaluated

WEDNESDAY, Oct. 28 (HealthDay News) -- In children, getting more sleep on weekends and holidays may reduce the risk of overweight or obesity associated with reduced sleep during weekdays, according to a Chinese study published online Oct. 26 in Pediatrics.

Abstract
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Link Between Nicotinic Acid and Atherosclerosis Examined

WEDNESDAY, Oct. 28 (HealthDay News) -- In patients with low high-density lipoprotein cholesterol (HDL-C) and atherosclerotic disease, daily use of high-dose nicotinic acid may help reduce atherosclerosis, according to research completed in the United Kingdom and published in the Nov. 3 Journal of the American College of Cardiology.

Abstract
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Racial Disparities Found in Breast Cancer Screening

WEDNESDAY, Oct. 28 (HealthDay News) -- In a statewide screening program for low-income women in South Carolina, race appeared to affect the time to completion of diagnostic workup following suspicious breast abnormalities, according to research published online Oct. 26 in Cancer.

Abstract
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Migraine With Aura Linked to Risk of Ischemic Stroke

WEDNESDAY, Oct. 28 (HealthDay News) -- People who have migraine headache with aura are at increased risk for ischemic stroke, particularly women, according to a meta-analysis of research on the links between migraines and cardiovascular disease published online Oct. 27 in BMJ.

Abstract
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Radiologists May Be Reluctant to Disclose Mammography Errors

WEDNESDAY, Oct. 28 (HealthDay News) -- Few radiologists say they would definitely disclose an error affecting the diagnosis of a patient with breast cancer, according to a study in the Oct. 28 issue of Radiology.

Abstract
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'Good' Cholesterol Levels May Boost Lipid Therapy Benefits

WEDNESDAY, Oct. 28 (HealthDay News) -- One of the key determinants of successfully preventing cardiovascular events with lipid therapy is raising high-density lipoprotein cholesterol levels, according to a study in the Oct. 26 issue of the Archives of Internal Medicine.

Abstract
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Contralateral Breast Cancer Risk High With Gene Mutation

WEDNESDAY, Oct. 28 (HealthDay News) -- Women with cancer in one breast who come from families with a hereditary breast cancer mutation have a nearly 50 percent long-term risk of developing cancer in the opposite breast, particularly if they are younger at first diagnosis, according to a study published online Oct. 26 in the Journal of Clinical Oncology.

Abstract
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Editorial

Clinicians Adhering More to Quality Improvement Program

WEDNESDAY, Oct. 28 (HealthDay News) -- Hospitals that are participants in the "Get With The Guidelines" program are showing improvements in adherence over time for both men and women as well as younger and older patients, according to a study published online Oct. 27 in Circulation: Cardiovascular Quality and Outcomes.

Abstract
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Testicular Cancer Survivors Report High Quality of Life

WEDNESDAY, Oct. 28 (HealthDay News) -- Long-term survivors of testicular cancer generally report a high quality of life, according to a study published online Oct. 26 in the Journal of Clinical Oncology.

Abstract
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Hormone Deficiency Shown to Impair Heart Function

WEDNESDAY, Oct. 28 (HealthDay News) -- Lack of adiponectin, an adipose-derived plasma protein that exerts anti-inflammatory and anti-hypertrophic effects, in aldosterone-induced hypertension worsens left ventricular hypertrophy and heart function in mice, according to a study published online Oct. 22 in Endocrinology.

Abstract
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Antipsychotic Drugs Can Cause Pediatric Weight Gain

TUESDAY, Oct. 27 (HealthDay News) -- The second generation of antipsychotic mediations cause weight gain and adverse changes in lipid and metabolic parameters, according to a study in the Oct. 28 Journal of the American Medical Association.

Abstract
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Liquid-Based Cytology Found No Better Than Pap Smear

TUESDAY, Oct. 27 (HealthDay News) -- Liquid-based cytology has no better sensitivity or specificity than conventional cytology for detection of cervical cancer precursors, according to a study in the Oct. 28 issue of Journal of the American Medical Association.

Abstract
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Noncardiovascular Deaths Add to Dialysis Patient Mortality

TUESDAY, Oct. 27 (HealthDay News) -- High overall death rates among patients beginning dialysis are not just the result of higher cardiovascular death rates, but of significantly higher noncardiovascular death rates as well, according to a study in the Oct. 28 issue of the Journal of the American Medical Association.

Abstract
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Majority of Americans Within Two Hours of a Burn Center

TUESDAY, Oct. 27 (HealthDay News) -- Seventy-nine percent of Americans are within two hours of an American Burn Association-verified care center, but access varies considerably by region and state, according to a study in the Oct. 28 issue of the Journal of the American Medical Association.

Abstract
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Venous Thromboembolism Risk Varies With Body Type

TUESDAY, Oct. 27 (HealthDay News) -- There is a positive, dose-dependent association between risk of venous thromboembolism and all the measurements of obesity, such as waist and hip circumference, according to a study published online Oct. 26 in Circulation.

Abstract
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Rising Down's Syndrome Trend as Maternal Age Increases

TUESDAY, Oct. 27 (HealthDay News) -- Although there has been an increase in the incidence of Down's syndrome in the United Kingdom since 1989, improved screening has offset the rise and the number of Down's syndrome births has slightly declined, according to a study published Oct. 26 in BMJ.

Abstract
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Homelessness, Marginal Housing Affect Mortality Risk

TUESDAY, Oct. 27 (HealthDay News) -- People living in shelters for the homeless and other marginal housing such as rooming houses and hotels are at higher risk of mortality than low income status alone can account for, according to a study published Oct. 26 in BMJ.

Abstract
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Rate of Cognitive Decline in Alzheimer's Disease Evaluated

TUESDAY, Oct. 27 (HealthDay News) -- In patients with diabetes mellitus (DM) and Alzheimer's disease, the presence of DM slows the rate of cognitive decline associated with Alzheimer's disease, according to a prospective, multi-center study in the Oct. 27 issue of Neurology.

Abstract
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Gender Gap in Midlife Heart Disease Risk Is Narrowing

TUESDAY, Oct. 27 (HealthDay News) -- The risk of midlife myocardial infarction is increasing for women, and vascular risk factor prevention should be given a higher priority, according to a study in the Oct. 26 issue of the Archives of Internal Medicine.

Abstract
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Neonatal Aluminum Exposure May Affect Later Bone Health

TUESDAY, Oct. 27 (HealthDay News) -- Preterm infants who are exposed to parenteral aluminum may have an increased risk of reduced lumbar spine and hip bone mass during adolescence, according to a study in the November issue of Pediatrics.

Abstract
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Decline in Cardiorespiratory Fitness Speeds Up After 45

MONDAY, Oct. 26 (HealthDay News) -- Aging does not necessarily spell a linear decline in cardiorespiratory fitness, with lifestyle factors playing an important role, according to a study in the Oct. 26 issue of the Archives of Internal Medicine.

Abstract
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Medical School Enrollment Continues to Expand

MONDAY, Oct. 26 (HealthDay News) -- Almost 18,400 students enrolled in medical school in the United States in 2009, a 2 percent increase over the previous year, but even more expansion is needed to meet future demand, according to an Oct. 20 report from the Association of American Medical Colleges (AAMC).

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Cortisol Linked to Bone Loss in Women With Anorexia

MONDAY, Oct. 26 (HealthDay News) -- Cortisol levels are higher in women with anorexia nervosa and hypothalamic amenorrhea than healthy women, and are strongly associated with depression, anxiety and bone loss, according to a study published online Oct. 16 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Coffee Drinking May Cut Risk of Liver Disease Progression

MONDAY, Oct. 26 (HealthDay News) -- People with advanced hepatitis C-related liver disease who drink three or more cups of coffee a day have lower risk of disease progression than non-coffee drinkers, according to a study in the November issue of Hepatology.

Abstract
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Far Fewer H1N1 Vaccine Doses Than Expected Are Available

MONDAY, Oct. 26 (HealthDay News) -- Because of production delays, far fewer than the goal of 40 million doses of H1N1 influenza vaccine will be available in the United States by the end of October, according to the U.S. Centers for Disease Control and Prevention. In addition, the U.S. Food and Drug Administration has issued an emergency use authorization for the investigational antiviral drug peramivir intravenous in certain patients with suspected or confirmed H1N1 infection.

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Steroid Adherence in Difficult Asthma Cases Examined

MONDAY, Oct. 26 (HealthDay News) -- In patients with difficult-to-control asthma, a significant proportion are non-adherent to inhaled and oral corticosteroid therapy, according to a study published in the Nov. 1 issue of the American Journal of Respiratory and Critical Care Medicine.

Abstract
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South Asians Show Higher Fat Mass Than Other Ethnicities

FRIDAY, Oct. 23 (HealthDay News) -- South Asians may have higher fat mass and lower lean mass than some other ethnic groups, which may be associated with increased Homeostasis Model Assessment (HOMA) and insulin levels, according to a study published online Oct. 9 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Death After Bariatric Surgery in Extremely Obese Examined

FRIDAY, Oct. 23 (HealthDay News) -- In patients who undergo bariatric surgery, extreme obesity and a high burden of chronic disease is associated with an increased risk of death within one year post-surgery, according to a study in the October issue of the Archives of Surgery.

Abstract
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Broad Asthma Screening May Offer Minimal Health Gains

FRIDAY, Oct. 23 (HealthDay News) -- The potential health benefits from asthma screenings in children seem to be smaller than previously expected, according to research published online Oct. 19 in Pediatrics.

Abstract
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Cocoa Can Reduce Levels of Inflammatory Biomarkers

FRIDAY, Oct. 23 (HealthDay News) -- In patients at high risk of cardiovascular disease, cocoa may significantly decrease levels of some inflammatory biomarkers, suggesting that the flavonoids in cocoa may help protect against atherosclerosis, according to a study in the Nov. 1 issue of the American Journal of Clinical Nutrition.

Abstract
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Hypertension and Cardiac Link During Pregnancy Analyzed

FRIDAY, Oct. 23 (HealthDay News) -- Women with a history of hypertensive disorders during pregnancy are at higher risk of cardiovascular and metabolic disorders, particularly if the hypertension is recurrent, according to a Norwegian study in the November issue of Obstetrics & Gynecology.

Abstract
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Dutch Trial Does Not Appear to Sway View on Tonsil Surgery

FRIDAY, Oct. 23 (HealthDay News) -- A 2004 trial finding equal benefits from adenotonsillectomy and watchful waiting in children moderately affected by throat infections or adenotonsillar enlargement had little effect on Dutch doctors' beliefs regarding the surgery, and tonsillectomy can treat vocal nasalance, according to two studies in the October Archives of Otolaryngology -- Head & Neck Surgery.

Abstract - Rovers
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Abstract - Subramaniam
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Effect of Male Fetus on Twin Pregnancy Outcomes Studied

FRIDAY, Oct. 23 (HealthDay News) -- Among twin pregnancies, the presence of a male fetus is associated with worse pregnancy outcomes such as prematurity and low birth weight, according to a study in the November issue of Obstetrics & Gynecology.

Abstract
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Childhood-Cancer Survivors at Risk of Suicidal Thoughts

FRIDAY, Oct. 23 (HealthDay News) -- Adult survivors of childhood cancers are more likely to have thoughts of suicide, particularly if they are in poor mental and physical health, according to a study published online Oct. 19 in the Journal of Clinical Oncology.

Abstract
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Liraglutide Beneficial for Non-Diabetic Obese Adults

FRIDAY, Oct. 23 (HealthDay News) -- In non-diabetic obese patients, treatment with liraglutide may significantly reduce weight, blood pressure, and symptoms of pre-diabetes, according to a study published online Oct. 23 in The Lancet.

Abstract
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Neonatal Outcomes Examined in Cancer Pregnancies

FRIDAY, Oct. 23 (HealthDay News) -- Pregnancies in women with cancer tend to have good outcomes overall, but have been associated with high rates of induced labor and newborn admission to a neonatal intensive care unit (NICU), according to a study published online Oct. 19 in the Journal of Clinical Oncology.

Abstract
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Two Treatments Can Improve Postviral Olfactory Loss

FRIDAY, Oct. 23 (HealthDay News) -- A combination of glucocorticoid treatment and Gingko biloba and glucocorticoid treatment alone are both effective in treating postviral olfactory loss, according to a study in the October issue of the Archives of Otolaryngology -- Head & Neck Surgery.

Abstract
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Rough Microdermabrasion May Be Better for Skin Remodeling

FRIDAY, Oct. 23 (HealthDay News) -- Using a coarse-grit hand piece to conduct microdermabrasion prompts sun-damaged skin to remodel itself in a process similar to wound healing, and may be more effective in dermal remodeling than medium-grit use, according to a study in the October issue of the Archives of Dermatology.

Abstract
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Article Reviews Techniques for Idiopathic Clubfoot Correction

THURSDAY, Oct. 22 (HealthDay News) -- The techniques for performing the Ponseti and French functional methods of treating idiopathic clubfeet were the focus of an article in a supplement to the October Journal of Bone & Joint Surgery.

Abstract
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Statins Not Associated With Surgical Site Infections

THURSDAY, Oct. 22 (HealthDay News) -- In elderly patients who undergo elective surgery, statin use is not associated with an increased or decreased risk of surgical site infection, according to a study in the October issue of the Archives of Surgery.

Abstract
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Study Examines Adding Insulin to Oral Antidiabetic Therapy

THURSDAY, Oct. 22 (HealthDay News) -- Type 2 diabetics on oral therapy appear to benefit most from the addition of basal insulin-based therapy, as compared to a prandial or biphasic insulin-based program, according to research published online Oct. 22 in the New England Journal of Medicine.

Abstract
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Some Hospital Staff Predicted to Be Infection Superspreaders

THURSDAY, Oct. 22 (HealthDay News) -- Hospital staff such as therapists and radiologists who are in contact with all patients have the potential to be superspreaders of infection if they fail to wash their hands regularly, according to a study published online Oct. 19 in the Proceedings of the National Academy of Sciences.

Abstract
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Levels of Cardiac Troponin T Linked to Heart Failure Events

THURSDAY, Oct. 22 (HealthDay News) -- Serum levels of cardiac troponin T (cTnT) are associated with increased risk of events for patients with stable heart failure, according to a study in the Oct. 27 issue of the Journal of the American College of Cardiology.

Abstract
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Pulmonary Embolism Found to Be Often Unrelated to DVT

THURSDAY, Oct. 22 (HealthDay News) -- In patients with pulmonary embolism, only a few have deep venous thrombosis (DVT) of the pelvic or proximal lower extremity veins, suggesting that pulmonary embolism originates in the lungs, according to a study in the October issue of the Archives of Surgery.

Abstract
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Pregnancy Weight Gain Can Affect Subsequent Retention

THURSDAY, Oct. 22 (HealthDay News) -- Obese women who gain excessive amounts of weight during pregnancy are at increased risk of retaining weight at one-year postpartum, according to a study in the November issue of Obstetrics & Gynecology.

Abstract
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Causes of Heart Failure Patient Rehospitalizations Examined

THURSDAY, Oct. 22 (HealthDay News) -- Most of the hospitalizations of heart failure patients subsequent to their diagnosis are for non-cardiovascular conditions, according to a study in the Oct. 27 issue of the Journal of the American College of Cardiology.

Abstract
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Obstetric Health Workers May Discourage Flu Vaccine

THURSDAY, Oct. 22 (HealthDay News) -- Many obstetric health care workers may have negative attitudes toward flu vaccinations during pregnancy, and the prophylactic use of influenza antivirals in pregnant women after exposure to an infected individual appears cost-effective during a pandemic, according to two studies in the November Obstetrics & Gynecology.

Abstract - Broughton
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Full Text - Lee

Heart Attack Outcomes May Be Better With On-Site Surgery

THURSDAY, Oct. 22 (HealthDay News) -- Patients with non-ST-segment elevation myocardial infarction (NSTEMI) have better outcomes if they present to a hospital with on-site cardiac surgery, according to a study in the October issue of the Journal of the American College of Cardiology: Cardiovascular Interventions.

Abstract
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Cisplatin Alone Effective in Children With Hepatoblastoma

WEDNESDAY, Oct. 21 (HealthDay News) -- Cisplatin alone is just as effective as, but less toxic than, cisplatin plus doxorubicin in children with standard-risk hepatoblastoma, according to a study in the Oct. 22 issue of the New England Journal of Medicine.

Abstract
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Gene Mutations Associated With Parkinson's Disease

WEDNESDAY, Oct. 21 (HealthDay News) -- Mutations in the glucocerebrosidase (GBA) gene are associated with Parkinson's disease, and mutations are associated with earlier disease onset and atypical clinical symptoms, according to a study in the Oct. 22 New England Journal of Medicine.

Abstract
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Novel H1N1 Vaccine Found Effective for Most Age Groups

WEDNESDAY, Oct. 21 (HealthDay News) -- A new influenza A (H1N1) vaccine developed in China successfully generated a protective immune response in subjects ranging in age from 12 to 60 years, according to a study published online Oct. 21 in the New England Journal of Medicine.

Abstract
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Higher Intensity Kidney Therapies Show Mixed Results

WEDNESDAY, Oct. 21 (HealthDay News) -- In critically ill adults with acute renal injury, higher-intensity renal-replacement therapy does not reduce mortality; however, in children with chronic kidney disease, higher-intensity blood-pressure control has beneficial effects on renal function, according to two studies in the Oct. 22 issue of the New England Journal of Medicine.

Abstract - Bellomo
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Abstract - Wühl
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Psychiatric Problems Affect Impact of Urinary Infections

WEDNESDAY, Oct. 21 (HealthDay News) -- Psychiatric health problems and sexual trauma are common among women who present with lower urinary tract infections, and these issues have an effect on the impact of such infections, according to a study published online Oct. 20 in advance of the December print issue of The Journal of Urology.

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Diabetes May Not Influence Heart Disease Outcomes

WEDNESDAY, Oct. 21 (HealthDay News) -- Diabetes mellitus does not affect outcomes in patients with unprotected left main coronary artery stenosis treated with drug-eluting stents or coronary artery bypass, according to a study in the October issue of the Journal of the American College of Cardiology: Cardiovascular Interventions.

Abstract
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Most H1N1 Hospitalizations Are in Young Patients

WEDNESDAY, Oct. 21 (HealthDay News) -- More than half of hospitalizations for H1N1 influenza are occurring in people younger than 25 years of age, and very few are occurring in the elderly, according to information presented at the Oct. 20 press briefing by the U.S. Centers for Disease Control and Prevention.

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Supervised Exercise Found Helpful in Treating Knee Pain

WEDNESDAY, Oct. 21 (HealthDay News) -- A program of supervised exercise is more effective than usual care in treating patellofemoral pain syndrome, according to a study published online Oct. 20 in BMJ.

Abstract
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Cost, Efficacy of HPV Vaccine in Older Women Explored

WEDNESDAY, Oct. 21 (HealthDay News) -- Giving human papillomavirus (HPV) vaccinations to older women may provide little absolute risk reduction at a high cost, according to a study in the Oct. 20 issue of the Annals of Internal Medicine.

Abstract
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Factors Contributing to Autism in Preterm Children Assessed

WEDNESDAY, Oct. 21 (HealthDay News) -- The higher risk of autistic disorders related to premature birth may be largely due to higher rates of prenatal and neonatal complications, according to research completed in Sweden and published online Oct. 19 in Pediatrics.

Abstract
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Medical Resident Skin Cancer Exam Training Evaluated

WEDNESDAY, Oct. 21 (HealthDay News) -- Medical students and residents do not get consistent access to training in how to conduct a skin cancer examination, and need more education on how to look for skin cancer during routine medical examinations, according to a study published in the October issue of the Archives of Dermatology.

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Clinical Approach for Invasive Fungal Disease Explored

WEDNESDAY, Oct. 21 (HealthDay News) -- A clinically driven approach to neutropenia-induced invasive fungal disease (IFD) can expedite diagnosis and reduce unnecessary antifungal treatment compared to standard empirical and preemptive strategies, according to a study published online Oct. 19 in the Journal of Clinical Oncology.

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Childhood Hyperactivity Linked to Shortened Nighttime Sleep

WEDNESDAY, Oct. 21 (HealthDay News) -- Children who are not able to sleep through the night are more likely to be hyperactive, with the risk especially high for boys with adverse family living conditions, according to a study published online Oct. 19 in Pediatrics.

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Sources Find Different Numbers of Active Physicians

WEDNESDAY, Oct. 21 (HealthDay News) -- Estimates from U.S. Census Bureau surveys find fewer older physicians remaining active compared with the American Medical Association Physician Masterfile data, according to research published in the Oct. 21 issue of the Journal of the American Medical Association.

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Cardiovascular Disease Linked to Hip Fracture Risk

TUESDAY, Oct. 20 (HealthDay News) -- The risk of hip fracture is much higher for people who have a diagnosis of cardiovascular disease (CVD), according to a study among Swedish twins reported in the Oct. 21 issue of the Journal of the American Medical Association.

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Aldosterone Antagonists May Be Underused in Heart Failure

TUESDAY, Oct. 20 (HealthDay News) -- Many heart failure patients are not receiving aldosterone antagonist therapy, though they may be candidates for it under professional prescribing guidelines, according to a study in the Oct. 21 issue of the Journal of the American Medical Association.

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Omega-3 Augmentation of Antidepressant Evaluated

TUESDAY, Oct. 20 (HealthDay News) -- Giving omega-3 fatty acids along with sertraline to patients with depression and coronary heart disease (CHD) did not augment the effect of the antidepressant, according to a study in the Oct. 21 issue of the Journal of the American Medical Association.

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Report Urges Nutritional Revamp for School Meals

TUESDAY, Oct. 20 (HealthDay News) - "School Meals: Building Blocks for Healthy Children," a report from the Institute of Medicine (IOM), recommends new nutritional targets and menu planning standards for the National School Lunch Program and the School Breakfast Program, to better meet the nutritional needs of the nation's school children and foster healthy eating habits.

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Effect of Microbicidal Wipes on Neonatal Sepsis Assessed

TUESDAY, Oct. 20 (HealthDay News) -- Chlorhexidine vaginal and neonatal wipes are ineffective in preventing sepsis and bacterial colonization of newborns, according to a study published online Oct. 20 in The Lancet.

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Role of Antihypertensives in Stable Heart Disease Studied

TUESDAY, Oct. 20 (HealthDay News) -- Patients with stable ischemic heart disease and preserved ventricular function may benefit from angiotensin-converting enzyme (ACE) inhibitors, according to a review published online Oct. 20 in the Annals of Internal Medicine.

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Childhood Hypertension Linked to Early Maturation

TUESDAY, Oct. 20 (HealthDay News)

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