MONDAY, Dec. 14 (HealthDay News) -- Patients with chronic kidney disease and high-grade carotid stenosis are at higher risk of stroke than those with preserved renal function, and they benefit more from carotid endarterectomy, according to a study published online Dec. 10 in the Journal of the American Society of Nephrology.
Anna Mathew, M.D., of the University of Western Ontario in London, Canada, and colleagues conducted a study of 1,490 patients with symptomatic stenosis, of whom 524 also had stage 3 chronic kidney disease, and 966 had reserved kidney function.
Stroke risk at two years was much higher among the patients with chronic kidney disease, at 31.6 percent versus 19.3 percent for those with preserved kidney function, the investigators discovered; and, while the former had an 82 percent reduced risk of ipsilateral stroke after carotid endarterectomy, the reduction was 51 percent for the latter group.
"Our results show patients with mild to moderate chronic kidney disease and symptomatic high-grade carotid stenosis have at least a similar and perhaps a larger absolute benefit in stroke reduction after endarterectomy, compared with those without chronic kidney disease," the authors write. "This study provides some of the best evidence for physicians and patients to help them make decisions about the appropriateness of endarterectomy."
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