Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for January 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Transient Elastography Offers Liver Disease Screening Tool
FRIDAY, Jan. 29 (HealthDay News) -- Transient elastography offers a new noninvasive screening test to detect or rule out significant fibrosis and early cirrhosis in patients with nonalcoholic fatty liver disease (NAFLD), according to a study in the February issue of Hepatology.
Three Autoantibodies Appear Common in Chagas' Disease
FRIDAY, Jan. 29 (HealthDay News) -- Three autoantibodies (AAB) are often present in patients with Chagas' disease and may identify asymptomatic patients most likely to develop clinical manifestations and serious complications, according to a study in the Feb. 2 Journal of the American College of Cardiology.
Colorectal Cancer Screening Approach Studied in Seniors
FRIDAY, Jan. 29 (HealthDay News) -- The use of computed tomographic (CT) colonography appears safe and effective for colorectal cancer screening in older individuals, according to research published in the February issue of Radiology.
Increased Medicare Copayments Affect Care Usage
WEDNESDAY, Jan. 27 (HealthDay News) -- In elderly patients, increasing copayments for ambulatory care may result in adverse health consequences and increased health care spending, according to a study in the Jan. 28 issue of the New England Journal of Medicine.
Rotavirus Vaccine Found to Be Effective in Africa and Mexico
WEDNESDAY, Jan. 27 (HealthDay News) -- Human rotavirus vaccine significantly reduces the incidence of severe rotavirus gastroenteritis and diarrhea-related mortality, according to two studies in the Jan. 28 New England Journal of Medicine.
Neoadjuvant Therapy Found Beneficial in Rectal Cancer
WEDNESDAY, Jan. 27 (HealthDay News) -- In patients with poor-risk, potentially operable rectal cancer, intensification of systemic therapy with neoadjuvant combination chemotherapy before standard treatment may result in good long-term outcomes, according to a study published online Jan. 26 in The Lancet Oncology.
Velcade Prescribing Information Changed
WEDNESDAY, Jan. 27 (HealthDay News) -- Takeda Oncology and the U.S. Food and Drug Administration have announced important revisions to the prescribing information for the drug Velcade (bortezomib) related to dosing in patients with hepatic impairment.
Imaging May Reduce Negative Appendectomy Rate in Women
TUESDAY, Jan. 26 (HealthDay News) -- The use of preoperative computed tomography (CT) in women under the age of 46 years with suspected acute appendicitis was associated with a lower rate of negative appendectomy, according to research published in the February issue of Radiology.
Race, Ethnicity Linked to Liver Cancer Survival
TUESDAY, Jan. 26 (HealthDay News) -- African-American patients with liver cancer have the worst survival among racial and ethnic groups even when they receive appropriate and equivalent treatment, according to a study published online Jan. 25 in Cancer.
Researchers Explain Link Between Obesity, Liver Cancer
MONDAY, Jan. 25 (HealthDay News) -- Obesity promotes hepatocellular carcinoma by stimulating production of two inflammatory cytokines, according to an animal study in the Jan. 22 issue of Cell.
Vitamin D Levels May Affect Risk of Colon Cancer
FRIDAY Jan. 22 (HealthDay News) -- There is an inverse association between pre-diagnostic circulating levels of vitamin D and the risk of colorectal cancer, although more research is needed to see whether increasing vitamin D concentration could lower the risk of the cancer, according to a study published online Jan. 21 in BMJ.
Disease Now Main Cause of Death in Darfur Conflict
FRIDAY, Jan. 22 (HealthDay News) -- Since 2005, disease has replaced violence as the leading cause of death in Darfur, especially among displaced populations, according to a study in the Jan. 23 issue of The Lancet.
Nurses Often Deeply Affected by Workplace Errors
THURSDAY, Jan. 21 (HealthDay News) -- Nurses are deeply affected by errors they make in the intraoperative environment and need more guidance on what constitutes an error in order to encourage more open reporting, according to a study in the Jan. 10 issue of the AORN Journal.
Treatments Linked to Lower Risk of C. difficile Recurrence
WEDNESDAY, Jan. 20 (HealthDay News) -- The use of two monoclonal antibodies targeting Clostridium difficile toxins was associated with fewer recurrences of infections, according to research published in the Jan. 21 issue of the New England Journal of Medicine.
Tylenol Recall in Effect Includes Several Other Drugs
WEDNESDAY, Jan. 20 (HealthDay News) -- McNeil Consumer Healthcare has recently expanded its voluntary recall of some over-the-counter drugs to include about 500 lots of products, according to officials from the Office of Compliance in the Center for Drug Evaluation and Research at the U.S. Food and Drug Administration.
Child Immunizations Confer Gastroenteritis Protection
TUESDAY, Jan. 19 (HealthDay News) -- A complete series of immunizations with pentavalent rotavirus vaccine (RV5) offers highly effective protection against pediatric rotavirus acute gastroenteritis, while even a partial series offers substantial acute gastroenteritis protection, according to a study published online Jan. 18 in Pediatrics.
Tracheostomy Tubes Linked to Pediatric Constipation
TUESDAY, Jan. 19 (HealthDay News) -- In children, tracheostomy tubes are associated with increased constipation, according to a study in the January issue of the Archives of Otolaryngology -- Head & Neck Surgery.
Specialization Can Improve Outcomes After Surgery
MONDAY, Jan. 18 (HealthDay News) -- Patients who undergo emergency colorectal surgery have better outcomes if the surgeon is specialized in colorectal surgery, according to a study in the January issue of the Archives of Surgery.
Constipation and Behavioral Problems in Children Studied
MONDAY, Jan. 18 (HealthDay News) -- Behavioral problems are three to four times more common in Dutch children with functional constipation than children in the general population, according to research published online Jan. 18 in Pediatrics.
Disparities Seen in United Kingdom Cancer Care
FRIDAY, Jan. 15 (HealthDay News) -- In the United Kingdom, social factors such as age, gender, and socioeconomic status continue to affect access to hospital care for common cancers, according to a study published online Jan. 14 in BMJ.
Patient Education Program Increases Donor Interest
THURSDAY, Jan. 14 (HealthDay News) -- An educational program on living donor liver transplantation (LDLT) increased waitlisted patients' knowledge and ability to discuss donations with family and friends, ultimately increasing both the number of donations and the number of prospective donors seeking evaluation, according to a study in the January issue of Liver Transplantation.
Stenting for Biliary Drainage in Pancreatic Cancer Studied
WEDNESDAY, Jan. 13 (HealthDay News) -- Placing a stent to facilitate biliary drainage prior to surgery in patients with cancer of the pancreatic head and obstructive jaundice increases complication rates and does not improve the outcome of the surgery, according to a study in the Jan. 14 New England Journal of Medicine.
Biomedical Research Funding Shows Decline in 2008
TUESDAY, Jan. 12 (HealthDay News) -- After increasing since 1994, annual funding for biomedical research topped out at $90.2 billion in 2007 and began to decline in 2008, according to a study in the Jan. 13 issue of the Journal of the American Medical Association.
Increased Caffeine Linked to Reduced Hepatic Fibrosis
MONDAY, Jan. 11 (HealthDay News) -- Increased coffee consumption may protect against advanced liver fibrosis, especially in patients with hepatitis C virus (HCV) infection, according to a study in the January issue of Hepatology.
Post-Transplant Liver Stiffness May Predict Fibrosis Risk
MONDAY, Jan. 11 (HealthDay News) -- In patients whose hepatitis C virus (HCV) infection recurs after liver transplantation, repeated liver stiffness measurements can distinguish between slow and rapid "fibrosers," according to a study in the January issue of Hepatology.
Quercetin Appears to Block Hepatitis C Virus Production
FRIDAY, Jan. 8 (HealthDay News) Quercetin, a natural heat shock protein inhibitor, may be a potential treatment for hepatitis C virus (HCV) infection, according to a study in the December issue of Hepatology.
Childhood Mistreatment Linked to Issues With Migraine
THURSDAY, Jan. 7 (HealthDay News) -- A history of childhood mistreatment is common in individuals with migraine, and childhood abuse and neglect are associated with chronic headaches and likelihood of comorbid pain conditions, according to a series of studies in the January issue of Headache.
Abstract - Study 1
Full Text - Study 1 (subscription or payment may be required)
Abstract - Study 2
Full Text - Study 2 (subscription or payment may be required)
Abstract - Study 3
Full Text - Study 3 (subscription or payment may be required)
Colonoscopy May Be Overused in Low-Risk Individuals
THURSDAY, Jan. 7 (HealthDay News) -- Surveillance colonoscopy is often overused in low-risk individuals without adenomas and underused in high-risk individuals with advanced adenomas, according to a study in the January issue of Gastroenterology.
Hemodialysis Linked to Higher Risk of Colonic Perforation
THURSDAY, Jan. 7 (HealthDay News) -- The risk of perforation during colonoscopy is much higher in patients undergoing hemodialysis, according to a study in the January issue of Clinical Gastroenterology and Hepatology.
St. John's Wort May Not Help Irritable Bowel Syndrome
THURSDAY, Jan. 7 (HealthDay News) -- The herb St. John's wort is not effective in treating irritable bowl syndrome (IBS), according to a study in the January issue of the American Journal of Gastroenterology.
Drug Shows Little Benefit for Irritable Bowel Syndrome
WEDNESDAY, Jan. 6 (HealthDay News) -- The selective serotonin reuptake inhibitor citalopram does not relieve symptoms or improve quality of life in patients with irritable bowel syndrome (IBS) better than placebo, according to a study in the January issue of Clinical Gastroenterology and Hepatology.
Chronic Constipation Linked to Colonic Motor Disturbances
TUESDAY, Jan. 5 (HealthDay News) -- Women with chronic constipation have colonic motor disturbances even if they have normal colonic transit, according to a study in the January issue of Gastroenterology.
Four-Drug Regimen Found Effective for Stomach Infection
TUESDAY, Jan. 5 (HealthDay News) -- Treatment with four drugs successfully eradicates Helicobacter pylori infection whether given sequentially or concomitantly, according to a study in the January issue of Clinical Gastroenterology and Hepatology.
Hepatitis C Treatment Effective in Injection Drug Users
MONDAY, Jan. 4 (HealthDay News) -- Treatment of recent hepatitis C virus (HCV) infection is effective in injection drug users, even those co-infected with HIV, according to a study in the January issue of Gastroenterology.
Genotype Can Figure in Cancer Prognosis and Treatment
MONDAY, Jan. 4 (HealthDay News) -- A patient's genotype can affect their prognosis in certain cancers, as well as their medication tolerance, and should be taken into account in evaluation and treatment, according to a pair of studies published online Dec. 28 in the Journal of Clinical Oncology.
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