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By Tamer M. Fouad, M.D. - July 16, 2009
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Topic: Cold agglutinin disease - by Tamer M. Fouad, M.D.
Cold agglutinin disease is an acquired autoimmune hemolytic anemia due to an IgM autoantibody usually directed against the I antigen on red blood cells. These IgM autoantibodies characteristically will not react with cells at 37 degrees centigrade but only at lower temperatures.
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