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By Jeffrey A. Gordon, M.D. - September 12, 2009
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Topic: Aspirin Use as Treatment in Colorectal Cancer: Teaching an Old Dog New Tricks - by Jeffrey A. Gordon, M.D.
Aspirin use can decrease the risk of colorectal adenomas. Full-dose, but not low-dose, aspirin may decrease the risk of developing colorectal cancer. Whether or not aspirin use can favorably augment survival in patients diagnosed with colorectal cancer is uncertain. Data to date in the literature raises intriguing concepts that targeting cyclooxygensae-2 (COX-2), which is overexpressed in up to 80-85% of colorectal cancers, may improve cancer-specific survival. Aspirin, COX-2 selective inhibitors (such as celecoxib), and nonselective NSAIDs are possible therapeutic agents. Prospective, randomized trials are needed to more definitively answer the questions of efficacy and safety.
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