Powered by


                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Ask a Doctor

   News via RSS







   Forum Archives





















   Primary Care






   Other Sections


   Research Tools

   Medical Tutorials

   Medical Software




Back to Infections Drug Index

Back to Antitubercular Agents

Name: Rifampin

Pregnancy Category C

Drug classes

  • Antituberculous drug ("first-line")
  • Antibiotic

Mechanisms of action

Inhibits DNA-dependent RNA polymerase activity in susceptible bacterial cells.


  1. Treatment of pulmonary tuberculosis in conjunction with at least one other effective antituberculous drug
  2. Neisseria meningitidis carriers, for asymptomatic carriers to eliminate meningococci from nasopharynx; not for treatment of meningitis
  3. Unlabeled uses: infections caused by Staphylococcus aureus and Staphylococcus epidermis, usually in combination therapy; gram-negative bacteremia in infancy; Legionella (Legionella pneumophilia), not responsive to erythromycin; leprosy (in combination with dapsone); prophylaxis of meningitis due to Haemophilus influenzae


  • Contraindicated in the presence of allergy to any rifamycin, acute hepatic disease, nursing a baby.
  • Use caution in pregnancy (teratogenic effects have been reported in preclinical studies; safest antituberculous regimen for use in pregnancy is considered to be rifampin, isoniazid, and ethambutol).
advertisement.gif (61x7 -- 0 bytes)

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application

Adverse effects

  • CNS: Headache, drowsiness, fatigue, dizziness, inability to concentrate, mental confusion, generalized numbness, ataxia, muscle weakness, visual disturbances, exudative conjunctivitis
  • GI: Heartburn, epigastric distress, anorexia, nausea, vomiting, gas, cramps, diarrhea, pseudomembranous colitis, pancreatitis, elevations of liver enzymes, hepatitis
  • Hematologic: Eosinophilia, thrombocytopenia, transient leukopenia, hemolytic anemia, decreased hemoglobin, hemolysis
  • GU: Hemoglobinuria, hematuria, renal insufficiency, acute renal failure, menstrual disturbances
  • Dermatologic: Rash, pruritus, urticaria, pemphigoid reaction, flushing, reddish-orange discoloration of body fluids-tears, saliva, urine, sweat, sputum
  • Other: Pain in extremities, osteomalacia, myopathy, fever, "flulike" syndrome

 advertisement.gif (61x7 -- 0 bytes)



We subscribe to the HONcode principles of the HON Foundation. Click to verify.
We subscribe to the HONcode principles. Verify here

Privacy Statement | Terms & Conditions | Editorial Board | About us
Copyright 2001-2012 DoctorsLounge. All rights reserved.