Back to Infections Drug Index

Back to 1st Generation Cephalosporins

Name: Cefaclor

Pregnancy Category B

Drug classes

Antibiotics
Cephalosporin (first generation)

Mechanism of action of Cefaclor
Bactericidal:  inhibits synthesis of bacterial cell wall, causing cell death.

Indications of Cefaclor

  • Lower respiratory tract infections caused by Streptococcus pneumoniae, Haemophilus influenzae, S. pyogenes
  • Upper respiratory infections caused by S. pyogenes
  • Dermatologic infections caused by Staphylococcus aureus, S. pyogenes
  • UTIs caused by E. coli, P. mirabilis, Klebsiella, coagulase-negative staphylococci
  • Otitis media caused by S. pneumoniae, H. influenzae, S. pyogenes, staphylococci

Unlabeled use: acute uncomplicated UTI in select patients, single 2-g dose

Contraindications of Cefaclor

  • Allergy to cephalosporins or penicillins
  • Renal failure
  • Lactation

Adverse effectsof Cefaclor

  • CNS: Headache, dizziness, lethargy, paresthesias
  • GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
  • Hematologic: Bone marrow depression
  • GU: Nephrotoxicity
  • Hypersensitivity: Ranging from rash, fever to anaphylaxis; serum sickness reaction
  • Other: Superinfections

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us