Back to Infections Drug Index
Pregnancy Category B
Cephalosporin (first generation)
Mechanism of action of Cefaclor
Bactericidal: inhibits synthesis of bacterial cell wall, causing
Indications of Cefaclor
- Lower respiratory tract infections caused by Streptococcus
pneumoniae, Haemophilus influenzae, S. pyogenes
- Upper respiratory infections caused by S. pyogenes
- Dermatologic infections caused by Staphylococcus aureus, S.
- UTIs caused by E. coli, P. mirabilis, Klebsiella, coagulase-negative
- Otitis media caused by S. pneumoniae, H. influenzae, S. pyogenes,
Unlabeled use: acute uncomplicated UTI in select patients, single
Contraindications of Cefaclor
- Allergy to cephalosporins or penicillins
- Renal failure
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Adverse effectsof Cefaclor
- CNS: Headache, dizziness,
- GI: Nausea, vomiting,
diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous
colitis, liver toxicity
- Hematologic: Bone marrow
- GU: Nephrotoxicity
- Hypersensitivity: Ranging
from rash, fever to anaphylaxis; serum sickness reaction
- Other: Superinfections