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Back to 1st Generation Cephalosporins

Name: Cefadroxil

Pregnancy Category B

Drug classes

Antibiotics
Cephalosporin (first generation)

Mechanism of action
Bactericidal:  inhibits synthesis of bacterial cell wall, causing cell death.

Indications

  • UTIs caused by E. coli, P. mirabilis, Klebsiella
  • Pharyngitis, tonsillitis caused by group A ?hemolytic streptococci
  • Dermatologic infections caused by staphylococci, streptococci

Contraindications

  • Allergy to cephalosporins or penicillins
  • Renal failure
  • Lactation

Adverse effects

  • CNS: Headache, dizziness, lethargy, paresthesias
  • GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
  • Hematologic: Bone marrow depression
  • GU: Nephrotoxicity
  • Hypersensitivity: Ranging from rash, fever to anaphylaxis; serum sickness reaction
  • Other: Superinfections

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