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Back to Infections Drug Index
Cefuroxime axetil
Ceftin, cefuroxime sodium
Kefurox, Zinacef
Pregnancy Category B
Drug classes
Antibiotics
Cephalosporin (second generation)
Mechanism of action
Bactericidal: inhibits synthesis of bacterial cell wall, causing
cell death.
Indications
Oral (Cefuroxime Axetil)
- Pharyngitis, tonsilitis caused by S. pyogenes
- Otitis media caused by S. pneumoniae, H. influenzae, M.
catarrhalis, S. pyogenes
- Lower respiratory tract infections caused by S. pneumoniae, H.
parainfluenxae, H. influenzae
- UTIs caused by E. coli, K. pneumoniae
- Dermatologic infections, including impetigo caused by S. aureus,
S. pyogenes
Parenteral (Cefuroxime Sodium)
- Lower respiratory tract infections caused by S. pneumoniae, S.
aureus, E. coli, Klebsiella, H. influenzae, S. pyogenes
- Dermatologic infections caused by S. aureus, S. pyogenes, E.
coli, Klebsiella, Enterobacter
- UTIs caused by E. coli, Klebsiella
- Uncomplicated and disseminated gonorrhea caused by N. gonorrhoea
- Septicemia caused by S. pneumoniae, S. aureus, E. coli,
Klebsiella, H. influenzae
- Meningitis caused by S. pneumoniae, H. influenzae, S. aureus, N.
meningitidis
- Bone and joint infections caused by S. aureus
- Perioperative prophylaxis
Contraindications
- Allergy to cephalosporins or penicillins
- Renal failure
- Lactation
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Adverse effects
- CNS: Headache, dizziness,
lethargy, paresthesias
- GI: Nausea, vomiting,
diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous
colitis, liver toxicity
- Hematologic: Bone marrow
depression: decreased WBC, decreased platelets, decreased Hct
- GU: Nephrotoxicity
- Hypersensitivity: Ranging
from rash to fever to anaphylaxis, serum sickness reaction
- Local: Pain, abscess at
injection site; phlebitis, inflammation at IV site
- Other: Superinfections,
disulfiram-like reaction with alcohol
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