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Loracarbef

Lorabid

Pregnancy Category B

Drug classes

Antibiotics
Cephalosporin (second generation)

Mechanism of action
Bactericidal:  inhibits synthesis of bacterial cell wall, causing cell death.

Indications

• Pharyngitis/tonsillitis caused by Streptococcus pyogenes
• Secondary bacterial infection of acute bronchitis and exacerabation of chronic bronchitis caused by S. pneumoniae, H. influenzae, M. catarrhalis
• Pneumonia caused by S. pneumoniae, H. influenzae
• Dermatologic infections caused by Staphylococcus aureus, S. pyogenes
• Urinary tract infections caused by E. coli, Staphylococcus saprophyticus 
• Otitis media caused by S. pneumoniae, H. influenzae, M. catarrhalis, S. pyogenes

Contraindications

• Allergy to cephalosporins or penicillins
• Renal failure
• Lactation

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Adverse effects

• CNS: Headache, dizziness, lethargy, paresthesias
• GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
• Hematologic: Bone marrow depression
• GU: Nephrotoxicity
• Hypersensitivity: Ranging from rash to fever to anaphylaxis, serum sickness reaction
• Local: Pain, abscess at injection site; phlebitis, inflammation at IV site
• Other: Superinfections

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