Back to Infections Drug Index
Pregnancy Category B
Cephalosporin (second generation)
Mechanism of action
Bactericidal: inhibits synthesis of bacterial cell wall, causing
- Pharyngitis/tonsillitis caused by Streptococcus pyogenes
- Secondary bacterial infection of acute bronchitis and
exacerabation of chronic bronchitis caused by S. pneumoniae, H.
influenzae, M. catarrhalis
- Pneumonia caused by S. pneumoniae, H. influenzae
- Dermatologic infections caused by Staphylococcus aureus, S.
- Urinary tract infections caused by E. coli, Staphylococcus
- Otitis media caused by S. pneumoniae, H. influenzae, M.
catarrhalis, S. pyogenes
- Allergy to cephalosporins or penicillins
- Renal failure
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- CNS: Headache, dizziness,
- GI: Nausea, vomiting,
diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous
colitis, liver toxicity
- Hematologic: Bone marrow
- GU: Nephrotoxicity
- Hypersensitivity: Ranging
from rash to fever to anaphylaxis, serum sickness reaction
- Local: Pain, abscess at
injection site; phlebitis, inflammation at IV site
- Other: Superinfections