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Back to Infections Drug Index
Cefixime
Suprax
Pregnancy Category B
Drug classes
Antibiotics
Cephalosporin (third generation)
Mechanism of action
Bactericidal: inhibits synthesis of bacterial cell wall, causing
cell death.
Indications
- Uncomplicated UTIs caused by E. coli, P. mirabilis
- Otitis media caused by H. influenzae (beta-lactamase positive
and negative strains), Moraxella catarrhalis, S. pyogenes
- Pharyngitis, tonsillitis caused by S. pyogenes
- Acute bronchitis and acute exacerbations of chronic bronchitis
caused by S. pneumoniae, H. influenzae (beta-lactamase positive and
negative strains)
- Uncomplicated gonorrhea caused by Neisseria gonorrhoeae
Contraindications
- Allergy to cephalosporins or penicillins
- Renal failure
- Lactation
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Adverse effects
- CNS: Headache, dizziness,
lethargy, paresthesias
- GI: Nausea, vomiting,
diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous
colitis, liver toxicity
- Hematologic: Bone marrow
depression
- GU: Nephrotoxicity
- Hypersensitivity: Ranging
from rash to fever to anaphylaxis, serum sickness reaction
- Other: Superinfections,
disulfiram-like reaction with alcohol
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