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Back to Infections Drug Index

Back to Penicillins

Amoxicillin

Amoxil, Polymox, Trimox,
Wymox

Pregnancy Category B

Drug classes

Antibiotics
Penicillins

Mechanism of action
Bactericidal: inhibits synthesis of cell wall of sensitive organisms, causing cell death.

Indications

  1. Infections due to susceptible strains of Haemophilus influenzae, E. coli, Proteus mirabilis, Neisseria gonorrhoeae, Streptococcus pneumoniae, streptococci, nonpencillinase-producing staphylococci 

Unlabeld use: Chlamydia trachomatis in pregnancy

Contraindications

  1. Contraindicated in the presence of allergies to penicillins,
    cephalosporins, or other allergens.

Use caution in the presence of renal disorders, lactation.

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Adverse effects 

  • CNS: Lethargy, hallucinations, seizures
  • GI: Glossitis, stomatitis, gastritis, sore mouth, furry tongue, black "hairy" tongue, nausea, vomiting, diarrhea, abdominal pain, bloody diarrhea, enterocolitis, pseudomembranous colitis, nonspecific hepatitis
  • Hematologic: Anemia, thrombocytopenia, leukopenia, neutropenia, prolonged bleeding time
    GU: Nephritis
  • Hypersensitivity reactions: Rash, fever, wheezing, anaphylaxis
  • Other: Superinfections-oral and rectal moniliasis, vaginitis
 

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